UCSF researchers have discovered a method for the isolation and expansion ex vivo of an endogenous population of bladder tumor-reactive cytotoxic CD4+ T cells that can be used to specifically and potently treat bladder cancer.
Bladder cancer is one of the most common types of cancers in the US, with approximately 80,000 new cases diagnosed in 2018 alone. Current treatments include checkpoint immunotherapy, a broad method of inhibiting a mechanism by which cancer cells evade the immune system.
Utilizing a novel combination of cell-surface markers, this method of isolating and expanding endogenous tumor reactive CD4+ T cells provides a more specific immune response towards the treatment of bladder cancer.
ADVANTAGES OF TECHNOLOGY
Researchers at UCSF, using single-cell RNA sequencing and T cell receptor sequencing of patient-derived bladder tumor cells, have identified a series of gene expression markers and specific T cell receptors specific to infiltrating bladder tumor resident CD4+ T cells. Utilizing these cell surface markers, they isolated this novel CD4+ T cell population, expanded it ex-vivo, and confirmed its cytotoxic potential.
To develop & commercialize the technology for cancer therapeutics.
Under CDA / NDA
|Patent Cooperation Treaty||Published Application||WO2019204338||10/24/2019||2018-159|