Aromatic 2-nitrosulfonyl fluoride antibiotics

Patent Status

Brief Description

Infections caused by drug-resistant Gram-negative bacteria (GNB) have quickly become a global problem in medicine and developing antibiotics has been challenging because of the onset of drug-resistant mechanisms and their low membrane permeability. Due to these membrane permeability limitations, numerous antibiotics have been developed against gram-positive bacteria have no efficacy against gram-negative bacteria. New approaches to enable the reliable, efficient monitoring and manipulation of live cells over a period of several weeks in a cost-effective format are therefore needed. 

UC Berkeley researchers have developed aromatic sulfonyl fluoride antibacterial agents that meet this need.  Gram-negative bacteria are notoriously difficult to target, thanks to their dual-membrane defense system that blocks both hydrophilic and hydrophobic drugs. This invention overcomes those barriers, providing a potent and permeable pharmacophore scaffold that delivers effective antibacterial activity.

Suggested uses

• Antibacterial agents for gram-negative bacteria

Advantages

• Designed to penetrate Gram-negative bacteria's defense layers.
• Provides a strong therapeutic solution
• Can be used in a range of antibiotic treatments for bacterial infections.