UCLA researchers in the Department of Dermatology have characterized a novel subset of CD8+ T cells, termed polycytotoxic, that mediate killing of intracellular pathogens.
CD8+ T cells are known to engage in cytotoxic activity, where they use pore-forming proteins and proteases (granzyme B, granulysin, and perforin) to induce apoptosis in target cells. This cytotoxic role is activated in response to intracellular infections, but it could be suppressed to prevent Graft vs. Host disease, autoimmune disease, and other abnormal immune responses. However, not all CD8+ T cells express those cytotoxic proteins, and the specific population(s) responsible for antimicrobial defense have not previously been identified.
Researchers at UCLA have identified a subset of CD8+ T cells called polycytotoxic T cells that express all the necessary cytotoxic proteins. By analyzing the surface expression, researchers also identified several biomarkers that can be used to purify this population of cells. Using in vitro functional testing, the polycytotoxic T cell subset was found to be more adept at killing intracellular pathogens.
Polycytotoxic T cells show increased killing of intracellular pathogens
Identified a subpopulation of T cells that expresses the necessary cytotoxic proteins
|United States Of America||Published Application||20190117689||04/25/2019||2016-676|
Additional Patent Pending
Polycytotoxic, T cells, CD8+, cytotoxic T cells, adaptive immunity; intracellular infection; antimicrobial; perforin; granzyme B; granulysin; Graft vs Host disease; vaccines; antibiotics; drug-induced hypersensitivity syndrome; Stevens-Johnson syndrome