Researchers at the University of California, Davis have found a number of peptides that bind to human secreted phospholipase A2 type IIA (sPLA2-IIA) and inhibit integrin signaling. These compounds show promise as therapies to decrease inflammation and cell proliferation, and may be developed for the treatment of conditions such as rheumatoid arthritis, asthma, Alzheimer’s disease, and cancer. These compounds may also function in screening assays for new compounds that inhibit integrin signaling.
sPLA2-IIA binds to a variety of integrin molecules, which in turn signal the formation of a number of potent mediators that induce disease-related cellular processes including inflammation, apoptosis, and atherogenesis. While inhibition of sPLA2-IIA is believed to hold promise as an effective treatment for inflammatory disease, it has been observed that even catalytically inactive sPLA2-IIA mutants are able to enhance inflammatory processes via integrin signal transduction. Therefore, researchers have continued to search for alternative methods to suppress sPLA2-IIA/integrin signaling.
Researchers at the University of California, Davis have identified several peptides that suppress the interaction between sPLA2-IIA and integrins, and can potentially inhibit inflammation and cell proliferation. These peptides have been shown to specifically bind sPLA2-IIA, and allow the interaction of other ligands to remain active, thereby only inhibiting the signaling via sPLA2-IIA.
|United States Of America||Issued Patent||10,591,471||03/17/2020||2015-192|
sPLA2, sPLA2-IIA, integrin signaling, inhibitor, inflammation, inflammatory disease, cell proliferation, suppressor