Cell Line for Drug Ototoxicity Screening and Hearing Research
Tech ID: 24290 / UC Case 2014-749-0
Innovation
Dr. Federico Kalinec of UCLA’s Department of Head & Neck Surgery has developed a cell line that expresses unique markers of sensory and supporting cells of the mammalian auditory organ, the organ of Corti. The cells, HEI-OC1 cells, are sensitive to drugs known to be ototoxic, such as aminoglycoside antibiotics and cisplatin, and unaffected by drugs known to be non-ototoxic. Thus, HEI-OC1 cells are useful for their applications in pharmacological drug research, chemical ototoxicity screening, and hearing research.
Related Materials
- A cochlear cell line as an in vitro system for drug ototoxicity screening. Audiol Neurootol. (2003)
- In vitro assessment of antiretroviral drugs demonstrates potential for ototoxicity. Hearing Research. (2014)
- Acetaminophen and NAPQI are toxic to auditory cells via oxidative and endoplasmic reticulum stress-dependent pathways. Hearing Research. (2014)
Contact
- UCLA Technology Development Group
- ncd@tdg.ucla.edu
- tel: View Phone Number.
Inventors
- Kalinec, Federico
Other Information
Keywords
cell line, ear, inner ear, ototoxicity, screening, drug discovery, pharmaceutical research, research tools, otolaryngology, organ of Corti
