Cell Line for Drug Ototoxicity Screening and Hearing Research

Tech ID: 24290 / UC Case 2014-749-0

Innovation

Dr. Federico Kalinec of UCLA’s Department of Head & Neck Surgery has developed a cell line that expresses unique markers of sensory and supporting cells of the mammalian auditory organ, the organ of Corti. The cells, HEI-OC1 cells, are sensitive to drugs known to be ototoxic, such as aminoglycoside antibiotics and cisplatin, and unaffected by drugs known to be non-ototoxic. Thus, HEI-OC1 cells are useful for their applications in pharmacological drug research, chemical ototoxicity screening, and hearing research.  

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Inventors

  • Kalinec, Federico

Other Information

Keywords

cell line, ear, inner ear, ototoxicity, screening, drug discovery, pharmaceutical research, research tools, otolaryngology, organ of Corti

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