Researchers at the University of California, Davis have discovered cartilage oligomeric matrix proteins (COMP) can bind and become an aggregate of growth factors.
COMP is an essential extracellular matrix protein that forms a “molecular bridge” between extracellular matrix components and provides a structure on which to bind. The modular structure of COMP acts as a scaffold aggregating multiple growth factors and presenting them to the cell surface. In addition to binding multiple TGF-β1 molecules, COMP contains additional binding sites for growth factors and cytokines, including members of the VEGF, FGF, and HGF families.COMP’s cell surface binding properties bring the aggregate complex of COMP and associated growth factors to the cell surface preventing diffusion of the growth factors, increasing the physiological relevance of the signaling, especially where multiple signals are required, and ultimately increasing the growth-related transcription within the cell.
|United States Of America||Issued Patent||9,133,259||09/15/2015||2011-089|