Propionibacterium acnes (P. acnes) bacteria is involved in many human polymicrobial diseases. It is the causative agent in acne vulgaris, a human polymicrobial disease. Acne vulgaris is the most common skin disease, affecting more than 85 percent of people at some time during their lives and currently affects more than fifty million people in the U.S. Current antibiotic therapy for acne lesions provides a non-specific treatment that kills the majority of skin bacteria and impacts the homeostasis of skin- and intestinal-resident flora.
Acne vulgaris can result in severe inflammatory lesions that are highly associated with P. acnes infection. There are no appropriate therapeutic modalities that are long-lasting and systemically effective and that specifically suppress P. acnes-induced pathogenesis and inflammation. In addition, these bacteria have the ability to trigger inflammatory responses. Many antibiotics have been used for acne treatment, but these antibiotics in general are non-specific, short lasting, and normally are applied when acne lesions have already occurred (such as in late stages of acne). Available topical treatments for acne lesions, including drugs, are palliative and effective only while treatment is maintained. When treatment is discontinued, increased acne gain inevitably results.
UC San Diego investigators have demonstrated a strategy to create anti-P. acnes vaccines targeting the secreted antigen CAMP factor. The vaccine was effective in an animal model both prophylactically and immunotherapeutically. Developing P. acnes vaccines could be an effective strategy to decrease P. acnes-induced inflammation.
In addition to treating acne vulgaris, an anti-P. acnes vaccine could benefit human polymicrobial P. acnes associated diseases, including endocarditis, endophthalmitis, osteomyelitis, joint, nervous system, cranial neurosurgery infections, and implanted biomaterial contamination.
Treatment of acne should be started as early as possible to minimize the risk of scarring and adverse psychological effects. Development of anti-acne vaccines may be able to prevent acne progression from the early stages and increase the specificity of treatments.
In vitro data and animal models.
Development of anti-acne vaccines may be able to prevent acne progression from the early stages and increase the specificity of treatments.
This technology is available for licensing
|United States Of America||Issued Patent||9,340,769||05/17/2016||2009-183|