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Browse Category: Medical > Disease: Dermatology

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Stimulation of Hair Growth

Currently-available treatments for human hair loss take months to show efficacy and have numerous side effects. No treatment exists for efficiently activating lasting hair growth. UCI scientists have discovered cell- and biological agent- based therapy to stimulate faster new hair growth compared to conventional treatments.

Method For Delivering Nanoshells Into Sebaceous Glands

Improved methods of treating acne and other sebaceous gland disorders by selectively targeting sebaceous glands.

Sieve Container For Contactless Media Exchange For Cell Growth

Media that contains nutrients and growth factors is necessary to grow all types of cells, a process that is widely used in many fields of research. Such media should be routinely changed either to different media or a fresh batch of the same media. This change currently involves either using a pipette to transfer cells from their current dish of media to a new dish, or aspirating the media out of the dish and replacing it with new media. Both methods have inherent risks to stressing and damaging the cells. Researchers at UCI have developed a unique dish for growing cells that allows for safer aspiration of the old media, which reduces stress and damage to the cells.

Assessment Of Wound Status And Tissue Viability Via Analysis Of Spatially Resolved Thz Reflectometry Maps

UCLA researchers in the Department of Bioengineering have developed an algorithm to assess the burn wound severity and predict its future outcomes using Terahertz imaging.

Imaging Platform Based On Nonlinear Optical Microscopy For Rapid Scanning Large Areas Of Tissue

The present invention discloses a nonlinear optical microscopy (NLOM) instrument for rapid imaging of wide areas and large volumes of biological tissues or other materials, ex vivo or in vivo, at sub-micron resolution. The instrument allows much larger field of view (FOV) at the same time improves the scan speed.

Methods for purifying and treating wounds with a proprietary biological agent, and to coat biomaterials designed to be synthetic substrates, aimed at promoting healing.

This invention describes methods for using a proprietary biological agent to improve the quality and speed of wound healing, and for coating a biomaterial to serve as an artificial epithelium for severe wounds. Also described are methods to produce high yields of the biological agent and of its purification.

Treatment of Chronic Cutaneous Wounds via Unique Topical Selective Serotonin Reuptake Inhibitors

Researchers at the University of California, Davis have developed a unique topical treatment for chronic cutaneous wounds using selective serotonin reuptake inhibitors.

Multiple in vivo tissue chromophores

The field of the invention generally relates to methods and devices used in diffuse optical spectroscopy. More specifically, the field of the invention generally relates to broadband diffuse optical spectroscopy methods and devices which are able to dynamically monitor multiple in vivo tissue chromophores. A device and method utilizes a broadband diffuse optical spectroscopy (DOS) system to dynamically calculate the concentrations of multiple chromophores in vivo using a non-invasive probe. The device and method permit dynamic monitoring of multiple in vivo tissue chromophores non-invasively with sensitivities necessary for effective therapeutic monitoring. The device includes a probe containing first and second source optical fibers as well as first and second detector optical fibers. The probe is placed adjacent to a sample of interest and detects reflected light which is passed to a proximally located detector and spectrometer. The concentrations of multiple chromophores are determined in real time. In a preferred embodiment, the multiple tissue chromophores include at least two of methemoglobin (MetHb), deoxyhemoglobin (Hb-R), oxyhemoglobin (Hb-O2), water (H2O), and methylene blue (MB). The device and method can be used quantify and monitor methemoglobin formation in subjects suffering from methemoglobinemia.

Synthetic Melanin-like Nanoparticles (MelNP) Act as Intracellular UV-shields

Melanin is a brown pigment that is delivered to keratinocytes in the skin after being excreted as melanosomes to form melanocytes. The primary function of melanin is to prevent UV-induced nuclear DNA damage. The biological system for induction, production, transfer and degradation of melanosomes is critical to controlling human skin health. Defects in melanin production in humans can cause diseases, such as skin cancer, vitiligo and albinism, many of which lack effective treatments due to their genetic origins. Therefore, there is an increasing interest in the production of synthetic melanin, as a substitute for natural melanin.

Novel Bioassay For Mitochondria Resistance To Cellular Stress: Clinical Applications

Researchers at UCLA have developed a sensitive and specific assay that measures a cell’s mitochondrial resistance to stress and could increase the success rate of in vitro fertilization procedures.

A Micro/Nanobubble Oxygenated Solutions for Wound Healing and Tissue Preservation

Soft-tissue injuries and organ transplantation are common in modern combat scenarios. Organs and tissues harvested for transplantation need to be preserved during transport, which can be very difficult. Micro and nanobubbles (MNBs) offer a new technology that could supply oxygenation to such tissues prior to transplantation, thus affording better recovery and survival of patients. Described here is a novel device capable of producing MNB solutions that can be used to preserve viability and function of such organs/tissue. Additionally, these solutions may be used with negative pressure wound therapy to heal soft-tissue wounds.

Unique Method Of Predicting Response To Immunotherapy For Human Melanoma

This invention describes a technical advancement in human tissue digestion that allows for the successful profiling of tumor infiltrating lymphocytes (TILs) by flow cytometry.  Using this digestion method, UCSF researchers were able to determine that patients with 30% or more TILs with high expression of biomarkers PD-1 and CTLA-4 are likely to respond to anti-PD-1 cancer immunotherapy.

Novel method for detection of O-Sulfonation sites on post-translationally modified proteins

Sulfonation of proteins and carbohydrates plays an important role in signaling, transport, and metabolism in the body. The degree to which a molecule is modified and at what positions dictates how that structure interacts within the body. UCI researchers have developed novel methods of detecting and mapping serine and threonine sulfonation of peptides and proteins.

Safe and Effective Dermal Decontamination Gel

This novel dermal gel formulation is an easy and highly effective method for removing and reducing absorption of skin contaminants.

Nanoporphyrin Nanoparticles for Combination Phototherapy and Drug Delivery to Infantile Hemangiomas

Researchers at the University of California Davis have developed a novel treatment method that combines photodynamic therapy and the therapeutic compound propranolol using a nanoparticle platform to treat infantile hemangiomas (IH).

Hyaluronic Acid-based Gel for Topical and Subcutaneous Applications

A method for producing chemically-crosslinked hydrogels using a biocompatible “click” chemistry for in situ gelation. 

Transposon Vector for Vertebrate & Invertebrate Genetic Manipulation

Background: Therapeutic delivery of genes is a rapidly evolving technique used to treat or prevent a disease at the root of the problem. The global transgenic market is currently $24B, growing at an annual projected rate of 10%. Currently, a variation of this technique is widely used on animals and crops for production of desirable proteins, but this is a heavily infiltrated market. Thus, entering the gene therapy segment is more promising and would enhance the growth of this industry.  Brief Description: UCR Researchers have identified a novel transposon from Aedes aegypti mosquitoes. This mobile DNA sequence can insert itself into various functional genes to either cause or reverse mutations. They have successfully developed a transposon vector system that can be used in both unicellular & multicellular organisms, which can offer notable insight to improve current transgenic technologies as well as methods of gene therapy.

Topical Treatment for Seborrhea (Oily Skin)

Researchers at UC Davis have discovered a compound that shows promise for the topical treatment of oily skin.

Method And Device For Skin Rejuvenation

A method and device for dermatology, cosmetic treatments, skin rejuvenation and scar reduction therapy

Active topical skin protectants using hybrid organic polysilsesquioxane materials

A topical skin protectant formulation containing a barrier cream and an active hybrid organic-inorganic polysilsesquioxane material for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWAs).

Shrink-Induced, Self-Driven Microfluidic Devices

The addition of novel surface modifications and use of shrink-wrap film to create devices will yield self-driven, shrink-induced microfluidic detection for samples such as bodily fluids. Novel fabrications and surfaces will have a profound impact on the creation of point of care diagnostics.

Imaging Guided Ablative Laser Surgery

Researchers at the University of California, Davis have devised an objective real-time method of visualizing the treatment area that will that will allow a laser surgeon to select appropriate ablative laser settings to treat a skin lesions and lesional tissues from other organ systems including, but not limited to: oral mucosa/gingiva, ear/nose and throat, esophagus, gastrointestinal, genitourinary, ophthalmologic and cardiopulmonary.

Compound for the Prevention Of Rosacea Inflammation

Rosacea is a chronic skin condition characterized by recurrent episodes of flushing, erythema, vasodilation, telangiectasia, edema, papules, pustules, hyperplasia, fibroplasia, itching, burning, pain, and skin tightness. Symptoms of rosacea are exacerbated by sun exposure, hot weather, immersion in hot water, high humidity, sweating, exercise, emotional stress, and spicy food. The skin condition usually begins between the ages of 30 to 50 and occurs more frequently in women than men. An estimated 16 million people are affected by rosacea inflammation in the United States. Oral and topical antibiotics are usually the first line of treatments prescribed for rosacea patients. However, they can cause serious side effects in some patients and do not address the underlying condition. Topical application of steroids may also help alleviate the symptoms, but it can also aggravate the condition. In addition, long term treatments can be inconvenient, lasting for as long as two years.

A Novel Basic Fibroblast Growth Factor Conjugate for Broad Therapeutic Application

UCLA scientists have developed a novel polymer conjugate of basic fibroblast growth factor (bFGF) for use in commercial and possibly clinical applications. This is the first bFGF conjugate to enhance bioactivity and stability under environmental stressors. 

Application of Topical Resveratrol in the Treatment of Acne

Researchers in UCLA Department of Dermatology have demonstrated through in vitro experiments that resveratrol, an ingredient in antioxidants and anti-aging products, generates sustained bactericidal and anti-inflammatory effects against P. acnes, the bacteria involved in the pathogenesis of acne.

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