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Apparatus and Methods for Stimulating DNA Repair Using Red Light Therapy

Red light exposure can have phototherapeutic effects on skin cells and other biological cells and tissues affected by UV damage. However, existing methods and devices using red light in DNA phototherapy have not identified the proper duration, intensity, or delivery mechanisms for optimal DNA repair. If the radiant intensity of the red light is too low, then exposure is inadequate and the repair biomarkers are not activated. Conversely, prolonged exposure to excessive electromagnetic radiation only furthers DNA damage. Moreover, in the context of skin treatment, excessive radiant intensity can burn tissue or have carcinogenic side effects. Thus, there is a need for a device and methods of use that provide safe, effective, and targeted red light DNA phototherapy.

Targeting Hyaluronan as an Immunomodulator for Treatment of Inflammatory Diseases

Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract and has been associated with poor quality of life and frequent complications requiring hospitalization and surgical procedures. Current therapies for IBD typically target neutralization of inflammatory cytokines, blockade of receptors, or inhibition of inflammatory cell functions. Despite current approaches, it is still difficult to control disease severity and maintain quality of life. One important phenotype of IBD that may offer an opportunity for gaining increased understanding of the disease is that up to 40% of individuals with inflammatory diseases of the colon have extra intestinal manifestations. Foremost in these extra intestinal symptoms are skin or oral disorders such as erythema nodosum, pyoderma gangreneosum and aphthous stomatitis. The presence of diseases associated with IBD at sites far from the gut support several hypotheses that IBD is a systemic disorder of circulating bone marrow derived immunocytes, a consequence of dysbiosis of the microbiome or a generalized disorder of epithelial function. Furthermore, appropriate function of the epithelial barrier is necessary to regulate the interactions between microbes and the host and maintain health.

Optical Coherence Tomography To View Assess And Count Hair Follicles

The invention is a portable imaging system for assessing the condition of hair loss. Optical coherence technology is adopted to provide an accurate, wide view and fast imaging solution. The system provides precise insight on the health of the hair follicle and its potential to regrow new hair, which is crucial for assessing the efficacy of hair regrowth treatments.

Scar Minimization Treatment: Fibrotic to Fat Cell Conversion

Clinical treatment for scar-less wound healing remains a highly desired, yet unmet need. UCI researchers have developed a method to minimize scarring during wound healing through cellular reprograming that encourages formation of new skin fat cells. This novel therapy is non-surgical and applicable to multiple types of scars and aging skin.

Biomarkers for Port Wine Stain and Related Syndromes

Researchers at the University of California, Irvine (UC Irvine) have discovered specific biomarkers that will enable innovations in diagnosis, prognosis, monitoring, and therapy of port wine stain (PWS) and other related syndromes.

Treatment Of Melanoma With Ferroptosis Inducing Agents

UCLA researchers in the Departments of Molecular and Medical Pharmacology and Medicine have developed a novel method to treat melanoma.

Use of ApoA-1 to Treat and Prevent Pro-Inflammatory Conditions

UCLA researchers in the Department of Obstetrics and Gynecology have discovered that ApoA-I can be used to treat and prevent pro-inflammatory skin conditions.

Handheld Blood-Flow Imaging Device

The invention is a medical handheld device that carries out skin visual inspection simultaneously with blood flow measurements through integrating a Laser Speckle Imaging (LSI) system within a handheld compact dermoscope. Combining both features in one compact, cheap and easy to use device will generate accurate and elaborative functional data that will improve the accuracy and detection of diseases such as cancer.

Novel Anti-Bacterial, Anti-Fungal Nanopillared Surface

Medical devices are susceptible to contamination by harmful microbes, such as bacteria and fungi, which form biofilms on device surfaces. These biofilms are often resistant to antibiotics and other current treatments, resulting in over 2 million people per year suffering from diseases related to these contaminating microbes. Death rates for many of these diseases are high, often exceeding 50%. Researchers at UCI have developed a novel anti-bacterial and anti-fungal biocomposite that incorporates a nanopillared surface structure that can be applied as a coating to medical devices.

Sieve Container For Contactless Media Exchange For Cell Growth

Media that contains nutrients and growth factors is necessary to grow all types of cells, a process that is widely used in many fields of research. Such media should be routinely changed either to different media or a fresh batch of the same media. This change currently involves either using a pipette to transfer cells from their current dish of media to a new dish, or aspirating the media out of the dish and replacing it with new media. Both methods have inherent risks to stressing and damaging the cells. Researchers at UCI have developed a unique dish for growing cells that allows for safer aspiration of the old media, which reduces stress and damage to the cells.

Assessment Of Wound Status And Tissue Viability Via Analysis Of Spatially Resolved Thz Reflectometry Maps

UCLA researchers in the Department of Bioengineering have developed an algorithm to assess the burn wound severity and predict its future outcomes using Terahertz imaging.

Imaging Platform Based On Nonlinear Optical Microscopy For Rapid Scanning of Large Areas Of Tissue

Researchers at UCI have developed a nonlinear optical microscopy (NLOM) instrument for the rapid and non-destructive imaging of wide areas and large volumes of biological tissue. Imaging can be performed either ex vivo or in vivo, and with sub-micron resolution at higher scanning speeds than previously possible.

Treatment of Chronic Cutaneous Wounds via Unique Topical Selective Serotonin Reuptake Inhibitors

Researchers at the University of California, Davis have developed a unique topical treatment for chronic cutaneous wounds using selective serotonin reuptake inhibitors.

Synthetic Melanin-like Nanoparticles (MelNP) Act as Intracellular UV-shields

Melanin is a brown pigment that is delivered to keratinocytes in the skin after being excreted as melanosomes to form melanocytes. The primary function of melanin is to prevent UV-induced nuclear DNA damage. The biological system for induction, production, transfer and degradation of melanosomes is critical to controlling human skin health. Defects in melanin production in humans can cause diseases, such as skin cancer, vitiligo and albinism, many of which lack effective treatments due to their genetic origins. Therefore, there is an increasing interest in the production of synthetic melanin, as a substitute for natural melanin.

Neutrophilic CXCR2 and BLT1: Therapeutic Targets for Acute Itch and Eczema

The inventors have demonstrated that CXCL1, a neutrophil chemoattractant and natural ligand for CXCR2, robustly induces itch when injected subcutaneously in mice. CXCL1 is the mouse homologue for human Interleukin-8, which is increased in several inflammatory skin disorders, including psoriasis and atopic dermatitis. The inventors have demonstrated that IL8 is increased in primary human keratinocytes upon activation by multiple itch agonists. Importantly, CXCL1-induced itch is entirely dependent on neutrophils. Further, mice lacking TRPA1 show reduced itch responses to CXCL1, and TRPA1 has previously been implicated in several forms of histamine-independent acute and chronic itch. In addition, loss of TRPA1 results in reduced CXCL1 expression in skin. Blocking/ablation of the high-affinity LTB4 receptor, BLT1, also results in reduction of CXCL1-induced itch. Both LTB4 and reactive oxygen species (ROS) are produced by neutrophils and have been proposed to directly activate neurons and induce itch. The inventors show that neutrophils also play a key role in chronic itch. In a mouse model of atopic dermatitis, depletion of neutrophils during induction of itch drastically reduces itch  and inflammatory responses. The inventors also show that CXCL1 is increased in multiple mouse models of chronic itch, and LTB4 is increased in skin of mice with atopic dermatitis. They propose that neutrophils activate sensory neurons through the ion channel TRPA1 in a CXCL1/BLT1/LTB4-dependent fashion.

Neuronal S1PR3: A Biomarker And Therapeutic Target For Acute And Chronic Itch

S1PR3 activation via its endogenous ligand (S1P) or a specific agonist evokes dose-dependent acute itch. S1PR3 activation via S1P at high doses evokes thermal but not mechanical pain. S1PR3 is expressed by a subset of nociceptors and pruriceptors which express the TRPA1 and TRPV1 ion channels, known to transduce itch and pain. S1PR3 activation evokes neuronal excitability via its stimulating actions on TRPA1 and TRPV1. S1PR3 activation evokes itch via TRPA1 and pain via TRPV1. S1PR3 gene expression is elevated in skin and sensory neurons in a mouse model of atopic dermatitis (eczema).  

A Micro/Nanobubble Oxygenated Solutions for Wound Healing and Tissue Preservation

Soft-tissue injuries and organ transplantation are common in modern combat scenarios. Organs and tissues harvested for transplantation need to be preserved during transport, which can be very difficult. Micro and nanobubbles (MNBs) offer a new technology that could supply oxygenation to such tissues prior to transplantation, thus affording better recovery and survival of patients. Described here is a novel device capable of producing MNB solutions that can be used to preserve viability and function of such organs/tissue. Additionally, these solutions may be used with negative pressure wound therapy to heal soft-tissue wounds.

Safe and Effective Dermal Decontamination Gel

This novel dermal gel formulation is an easy and highly effective method for removing and reducing absorption of skin contaminants.

Nanoporphyrin Nanoparticles for Combination Phototherapy and Drug Delivery to Infantile Hemangiomas

Researchers at the University of California Davis have developed a novel treatment method that combines photodynamic therapy and the therapeutic compound propranolol using a nanoparticle platform to treat infantile hemangiomas (IH).

Transposon Vector for Vertebrate & Invertebrate Genetic Manipulation

Background: Therapeutic delivery of genes is a rapidly evolving technique used to treat or prevent a disease at the root of the problem. The global transgenic market is currently $24B, growing at an annual projected rate of 10%. Currently, a variation of this technique is widely used on animals and crops for production of desirable proteins, but this is a heavily infiltrated market. Thus, entering the gene therapy segment is more promising and would enhance the growth of this industry.  Brief Description: UCR Researchers have identified a novel transposon from Aedes aegypti mosquitoes. This mobile DNA sequence can insert itself into various functional genes to either cause or reverse mutations. They have successfully developed a transposon vector system that can be used in both unicellular & multicellular organisms, which can offer notable insight to improve current transgenic technologies as well as methods of gene therapy.

Method And Device For Skin Rejuvenation

A method and device for dermatology, cosmetic treatments, skin rejuvenation and scar reduction therapy

Active topical skin protectants using hybrid organic polysilsesquioxane materials

A topical skin protectant formulation containing a barrier cream and an active hybrid organic-inorganic polysilsesquioxane material for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWAs).

Shrink-Induced, Self-Driven Microfluidic Devices

The addition of novel surface modifications and use of shrink-wrap film to create devices will yield self-driven, shrink-induced microfluidic detection for samples such as bodily fluids. Novel fabrications and surfaces will have a profound impact on the creation of point of care diagnostics.

Compound for the Prevention Of Rosacea Inflammation

Rosacea is a chronic skin condition characterized by recurrent episodes of flushing, erythema, vasodilation, telangiectasia, edema, papules, pustules, hyperplasia, fibroplasia, itching, burning, pain, and skin tightness. Symptoms of rosacea are exacerbated by sun exposure, hot weather, immersion in hot water, high humidity, sweating, exercise, emotional stress, and spicy food. The skin condition usually begins between the ages of 30 to 50 and occurs more frequently in women than men. An estimated 16 million people are affected by rosacea inflammation in the United States. Oral and topical antibiotics are usually the first line of treatments prescribed for rosacea patients. However, they can cause serious side effects in some patients and do not address the underlying condition. Topical application of steroids may also help alleviate the symptoms, but it can also aggravate the condition. In addition, long term treatments can be inconvenient, lasting for as long as two years.

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