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Half-Virtual-Half-Physical Microactuator

Researchers at the University of California, Davis have developed a half-virtual-half-physical microactuator that utilizes a combination of computational models and microelectromechanical systems for use in medical devices and mechanical systems.

Titanium Plates For Bone Regeneration

UCLA researchers in the School of Dentistry at the Weintraub Center for Reconstructive Biology have developed a new titanium plate to promote bone regeneration in dental reconstruction procedures.

A Highly Error-Prone Orthogonal Replication System For Targeted Continuous Evolution In Vivo

Inventors at UC Irvine have engineered an orthogonal DNA replication system capable of rapid, accelerated continuous evolution. This system enables the directed evolution of specific biomolecules towards user-defined functions and is applicable to problems of protein, enzyme, and metabolic pathway engineering.

Novel Targets And Use Of Small Molecule BT-2 To Treat Heart Failure, Obesity And Diabetes

UCLA researchers from the Cardiovascular Theme in the Departments of Anesthesiology, Physiology and Medicine have discovered new pathways and potential treatment options for heart failure, obesity, and diabetes

Mobile Phone Based Fluorescence Multi-Well Plate Reader

UCLA researchers have developed a novel mobile phone-based fluorescence multi-well plate reader.

Bioorthogonally-Engineered Extracellular Vesicles for Applications in Detection and Therapeutic Delivery

Extracellular vesicles (EVs) are promising as drug delivery carriers because they are inherently biocompatible, It would be desirable to efficiently, specifically, and rapidly change the EVs surface presentation to program the interactions with its target cells. Inventors at UC Irvine have developed a strategy for functionalizing the cellular membranes of EVs with precision and ease.

Electrode Agnostic, Supply Variant Stimulation Engine For Implantable Neural Stimulation

UCLA researchers in the Department of Electrical Engineering have invented an innovative universal agnostic electrode for implantable neural stimulation and sensing.

Load Adaptive, Reconfigurable Active Rectifier for Multiple Input Multple Output (MIMO) Implant Power Management

UCLA researchers in the Department of Electrical Engineering have invented a novel full-fledged implant power management unit, which is highly programmable and can process multiple input power deliveries on-chip.

A High Dynamic-Range Sensing Front-End For Neural Signal Recording Systems

UCLA researchers in the Department of Electrical Engineering have invented a novel neural recording chopper amplifier for neuromodulation systems that can simultaneously record and stimulate.

Predictive Optimization Of Pharmeceutical Efficacy

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a machine learning platform to virtually screen combinatorial drug therapies.

Plasmon Resonance Enhanced Optical Means for Surface Disinfection

UCLA researchers in the Department of Materials Science and Engineering have developed a novel surface disinfection material for use in hospital coatings.

High-Efficiency One-Cell-One-Bead Encapsulation In Droplets

A high-efficiency single-cell droplet encapsulation method to improve single cell pharmacological assay throughput.

Scalable Manufacturing Of Superhydrophobic Structures In Plastics

Superhydrophobic surfaces that repel liquid have found a multitude of applications due to their self-cleaning and antibacterial effects, but are often highly surface selective and difficult to produce. Researchers at UCI have developed a new method to reliably mass produce universal superhydrophobic surfaces in a simpler and more cost effective manner.

Drift-Free and Calibration-Free Measurement of Analytes

A method of achieving the calibration- and drift-free operation of voltammetric electrochemical biosensors.

Bacteria from Medicago Root Nodules as Potentialy Useful PPB (Plant Probiotic Bacteria) for Agriculture

UCLA researchers in the Department of Molecular, Cell, and Developmental Biology have discovered new species of plant probiotic bacteria to enhance plant growth for agricultural purposes.

Non-Invasive Bladder Volume Sensing Device

Researchers at the University of California, Davis have developed an apparatus and methods for non-invasive bladder volume sensing, to determine when a patient’s bladder is full.

A Way to Genetically Silence Calcium Signaling in Cells and Organisms and Derivates Thereof

UCLA researchers in the Department of Physiology have developed a method of genetically silencing calcium signaling in cells and organisms for use in studying aberrant calcium signaling in disease.

Wireless In Situ Sensors in Stents for the Treatment and Monitoring of Chronic Obstructive Lung Disease (COPD)

UCLA researchers in the Department of Electrical Engineering have developed a novel wireless sensor for external and internal biosensing applications.

Exercise Promotion, Measurement, and Monitoring System

UCLA researchers in the Department of Electrical Engineering have developed a novel wireless sensor and exercise system for real-time exercise promotion and monitoring.

Bispecific Antibodies for Detection and Treatment of Cancers Associated with EGFR Overexpression

This invention identifies novel bispecific antibodies that can be used to detect and/or treat various cancers that overexpress EGFR family of proteins.

Polyketide Synthase Variants And Uses Thereof

Polyketide synthases are multifunctional enzymes that catalyze the biosynthesis of polyketides. These enzymes make attractive targets because they can be modified to produce commodity chemicals. The invention herein describes methods for producing polyketide synthase variants whose activity and/or substrate specificity can be tailored. An example of a polyketide synthase variant would be 2-pyrone synthase, which produces 2-pyrone. Other modified synthase variants can be generated to produce other key materials including ketides, lactones, etc.

Drift-Free, Self-Calibrated Interrogation Method For Electrochemical Sensors Based On Electron Transfer Kinetics

A new method using chronoamperometry in place of voltammetry to obtain data from electrochemical sensors, including electrochemical biosensors.

Efficient Induction of Haploid Plants

Researchers at the University of California, Davis have developed an efficient technique for the haploid induction of plants.

Novel Inhibitors of Mitochondrial Electron Transport

Researchers at the University of California, Davis have discovered a class of compounds that both bind to a unique newly-discovered binding site in respiratory complex III and act as inhibitors of electron transport for use as mitochondrial anti-cancer drugs.

Biologically Applicable Water-Soluble Heterogeneous Catalysts For Parahydrogen-Induced Polarization

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method of parahydrogen-induced polarization in water using heterogeneous catalysts.

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