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Nanoporphyrin Nanoparticles for Combination Phototherapy and Drug Delivery to Infantile Hemangiomas

Researchers at the University of California Davis have developed a novel treatment method that combines photodynamic therapy and the therapeutic compound propranolol using a nanoparticle platform to treat infantile hemangiomas (IH).

X-Ray-Triggered Release of Drugs from Nanoscale Drug Carriers

Researchers at the University of California, Davis have identified a means by which large quantities of inactive drugs (particularly chemotherapeutics) can be delivered by nanoscale drug carriers to a target location where they can be rendered active by X-rays.

UCLA Inventors Create Platform Technology to Create Customizable Nanoscale Particles and Gels for Use in the Industrial Biomaterials Market

UCLA researchers in the Departments of Chemistry, Physics, and Bioengineering, led by Dr. Tim Deming of the Bioengineering department, have developed a platform to create and modify nanoscale particles and gels for use in the industrial biomaterials market. The polypeptide based delivery vehicle platforms created by the Deming group are customizable in nearly all physical characteristics, can be tailored in size, loaded with hydrophobic and hydrophilic payloads, used in coatings, are fully synthetic, possess highly reproducible properties, and are inexpensive to prepare compared to solid-phase peptide synthesis.The platform can be used to create novel, need-based nanoscale vesicles or injectable hydrogels, and can also be used to augment existing materials systems.

UCLA Inventors Create Platform Technology to Create Customizable Nanoscale Wound Management Tools

UCLA researchers in the Departments of Chemistry, Physics, and Bioengineering, led by Dr. Tim Deming of the Bioengineering department, have developed a platform to create and modify nanoscale vesicles and hydrogels for use in wound management. The poly-peptide based platforms created by the Deming group are customizable in nearly all physical characteristics, can be tailored in size, be loaded with hydrophobic, hydrophilic, or cellular payloads, adaptable to specific delivery locations, low toxicity, are fully synthetic, possess highly reproducible properties, and are inexpensive to prepare compared to solid-phase peptide synthesis. The platform can be used to create novel, need-based nanoscale vesicles or injectable hydrogels, and can be used to augment existing material systems.

UCLA Inventors Create Platform Technology to Create Customizable Nanoscale Particles and Gels for Use in the Industrial Biomaterials Market

UCLA researchers in the Departments of Chemistry, Physics, and Bioengineering, led by Dr. Tim Deming of the Bioengineering department, have developed a platform to create and modify nanoscale particles and gels for use in the industrial biomaterials market. The polypeptide based delivery vehicle platforms created by the Deming group are customizable in nearly all physical characteristics, can be tailored in size, loaded with hydrophobic and hydrophilic payloads, used in coatings, are fully synthetic, possess highly reproducible properties, and are inexpensive to prepare compared to solid-phase peptide synthesis.The platform can be used to create novel, need-based nanoscale vesicles or injectable hydrogels, and can also be used to augment existing materials systems.

UCLA Inventors Create Platform Technology to Create Customizable Nanoscale Drug Delivery Materials

UCLA researchers in the Departments of Chemistry, Physics, and Bioengineering, led by Dr. Tim Deming of the Bioengineering department, have developed a platform to create and modify nanoscale drug delivery particles. The poly-peptide based platforms created by the Deming group are customizable in nearly all physical characteristics, can be tailored in size, loaded with hydrophobic and hydrophilic payloads, adaptable to specific delivery locations, low toxicity, are fully synthetic, possess highly reproducible properties, and are inexpensive to prepare compared to solid-phase peptide synthesis.The platform can be used to create novel, need-based nanoscale vesicles or injectable hydrogels, and can also be used to augment existing nanoparticle systems.

UCLA Inventors Create Platform Technology to Create Customizable Materials for Imaging and Detection

UCLA researchers in the Departments of Chemistry, Physics, and Bioengineering, led by Dr. Tim Deming of the Bioengineering department, have developed a platform to create and modify nanoscale vesicles and hydrogels for use in imaging and detection.The poly-peptide based platforms created by the Deming group are customizable in nearly all physical characteristics, can be tailored in size, be loaded with hydrophobic and hydrophilic payloads, adaptable to specific delivery locations, low toxicity, are fully synthetic, possess highly reproducible properties, and are inexpensive to prepare compared to solid-phase peptide synthesis.The platform can be used to create novel, need-based nanoscale vesicles or injectable hydrogels, and can also be used to augment existing nanoparticles.

Nanomotor Photolithography

The rapid miniaturization of devices and machines has fueled the evolution of advanced fabrication techniques. However, current technologies of nanopatterning are still limited by the resolution of the pattern, the major cost of implementation, range of patterns that can be written, the patterning speed as well as the environment where such a technique can be used. The complexity and high cost of state-of-the-art high-resolution lithographic systems have prompted unconventional routes for nanoscale patterning. Inspired by the sophistication of natural nanomachines, synthetic nanomotors have recently demonstrated remarkable performance and functionality.

Process for the Fabrication of Nanostrucured Arrays on Flexible Polymer Films

The technology is a process for making arrays of nanostructures on polymer films.It features a two step process for creating thin polymer films with unique optical and wetting properties that can be used for coating both planar and curved surfaces.It is possible to implement this process in a mass fabrication process over large areas.

Novel Multivalent Bioassay Reagents

The guiding principle for the creation of biomolecular recognition agents has been that affinity is essential for both strength and specificity.  Monoclonal antibodies, the dominant workhorse of affinity reagents, have mono-valent affinities in the uM-nM range with apparent affinities that can be sub nM with the bi-valency intrinsic in intact immunoglobulin structure.  The avidin-biotin interaction used ubiquitously for biomolecular assembly is femto-molar and both highly specific and essentially irreversible.  High affinity has been proclaimed the essential goal for the selection of useful specific aptamers, though there has been disagreement about a tight coupling of affinity and specificity.  

Activating HIV Latency Using Drug Encapsulated Nanoparticles

UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have devised a novel method to target the HIV virus in patients using nanoparticles loaded with therapeutic agents.

Self-Assembled Modified Beta Solenoid Protein Scaffolds for Devices And Materials

Available for licensing are patent rights in novel and versatile beta solenoid proteins that are useful as scaffolds for nanoparticle assembly, photocatalytic devices, thermoelectric devices, passive absorption of small atoms or molecules, cement additive, heavy element remediation, heavy element absorption, and as biological catalysts.

Imprinted Polymer Nanoparticles

Synthetic polymer nanoparticles (NPs) capable of recognizing specific biomacromolecules and can be used as substitutes for natural antibodies .

Stimuli-Sensitive Intrinsically Disordered Protein Brushes

Recent advances in biomedicine and biotechnology are driving the demand for novel surface functionalization platforms for biologically active molecules. Polymer brush coatings form when macromolecular chains are end-tethered to surfaces at high grafting densities. While there have been notable successes integrating polymer brush coatings with proteins to control biological function, such strategies require covalent conjugation of the protein to the polymer, which can be inefficient and can compromise biological function. Moreover, these polymer brushes almost universally feature synthetic polymers, which are often heterogeneous and do not readily allow incorporation of chemical functionalities at precise sites along the constituent chains. To address these challenges, Researchers at the University of California, Berkeley (UCB) conducted experiments with polymer brushes based on nerve cell neurofilaments as the intrinsically disordered protein (IDP). By cloning a portion of a gene that encodes one of the neurofilament bristles, and re-engineering it such that they could attach the resulting protein to surfaces, UCB investigators have developed a biomimetic, recombinant IDP that can assemble into an environment-sensitive protein brush that swells and collapses dramatically with environmental changes in solution pH and ionic strength. Their research demonstrates that stimuli-responsive brushes can be efficiently integrated with proteins without compromising biological function, which could have broad commercial appeal as a new class of smart biomaterial building blocks.

Regionally Activated Drug Delivery Nanoparticles

A major challenge facing nanoparticle-based drug delivery vehicles with chemotherapy payloads is accumulation in healthy tissue through passive extravasation as well as active uptake by the reticulo-endothelial system. These healthy tissues get a dose of the active drug once the nanoparticles begin to break down resulting in dose limiting side effects. New approaches and platforms are needed to address this issue.

Carbon Nanotube Trans-Membrane Channels Mimicking Biological Porins

Existing examples of nanopores fall into three categories: synthetic ion channels made by bottom-up synthesis and providing a mimic of the transmembrane pore, solid-state nanopores, usually drilled or etched out of solid pieces of material matrix, and biological nanopores made by isiolating a naturally-occurring protein. The carbon nanotube trans-membrane channels invention is a new class of nanopores that combines the best features of all three existing types of pores while substantially mitigating a number of shortcomings exhibited by each of these types of pores. The method involves sonication of nanotube in presence of lipids, including but not limited to DOPC or DPhPC.

Stimuli Responsive Based Digital Biosensors For The Measurement Of Oxidative Stress

Oxidative stress and reactive oxygen species (ROS) are the hallmarks of many disorders, including drug-associated toxicity, atherosclerosis, cancer, and degenerative processes associated with aging. Routine monitoring of circulating ROS in a point-of-care (POC) manner would reduce morbidity and mortality. However, current methods for measuring oxidative stress and lipid peroxidation rely on label-based fluorescence transduction methods for optical detection. This is laborious, lengthy and requires accurate optical instrumentation. It is also expensive and difficult to miniaturize, making it impractical for POC use in low-resource settings. Developing electrochemical biosensors for POC applications has been challenging due to the difficulties in combining the query biomolecule receptor with an electrical transducer to produce an electrical signal in presence of the query biomolecule for a simple, accurate and inexpensive platform for patient diagnosis.Investigators at UC Berkeley have met this challenge with the ROSchip innovation. ROSchip is an oxidative stress digital biosensor, a lab-on-a-chip device which has a novel stimuli responsive polymer for early detection of circulating ROS in blood. The ROSchip’s data provides accurate management of cardiovascular and atherosclerosis diseases in routine clinical practices. Circulating lipid hydroperoxides (LPH), the primary biomarkers of lipid oxidation, predict cardiovascular events in patients with a history of cardiovascular disease. The ROSchip provides accurate, cost-effective, and fast assessment and monitoring of LPH. The ROSchip system is designed with interdigitated electrodes coated with a thin film of ROS-responsive polymer. The ROS generates an electrical signal indicating LPH present in a sample. 

Novel Chitosan Derivative as a Systemic Drug Delivery Agent and an Antibiotic Treatment

Researchers at the University of California, Irvine have developed a novel chitosan derivative that may be used simultaneously as a systemic drug delivery agent and a systemic antibiotic treatment.

Noise Reduction for DNA and Other Macromolecules Sequencing Using Oversampling and Cross-Correlations

Sequencing of macromolecules and especially of DNA is an extremely important area for biology, medicine and pharmacology. Developing realistic inexpensive methods for sequencing is becoming a crucial area for research and technological development. Current alternatives to standard PCR sequencing methods use serial physical property measurements. The key problem with these methods is that they are very susceptible to a large number of noise sources, which make their use problematic, perhaps impossible. Therefore development of a noise reduction scheme becomes imperative.

Single-Molecular Homogenous Amplified Detection in Confined Volumes

This novel method detects the concentration of molecules of interest without washing steps or any solid-phase reaction.

Methods for Electrospun Fibrous Scaffolds

Controlling the structure and organization of electrospun fiber is desirable for fabricating scaffolds and materials with precise microstructures for use in textile, filtering materials, wound healing, drug delivery, and tissue engineering. Manufacturing by electrospinning templates for controlling the microstructure architecture is inherently complicated and non-dynamic, and typically slow and expensive. Moreover, conventional electrospinning techniques are prone to mechanical instabilities, including distortion, shrinkage, and delamination or pore collapse. To help solve these problems, researchers at Berkeley created methods and technology to control fiber deposition in electrospinning using unique microfabrication means. In one instance, investigators performed an animal study with electrospun scaffolds to assess collagen deposition in histologic cross sections of spun scaffolds. Early data results related to the new materials and structures suggest superior fiber organization, porosity, biocompatibility, and biological performance properties, which may have broad industrial applications, from materials microfabrication to clinical therapies.

System And Methods For Fabricating Boron Nitride Nanostructures

A research team led by Alex Zettl has developed a variable pressure, powder/gas/liquid injection inductively coupled plasma system that is used to produce high quality boron nitride nanotubes (BNNTs) at continuous rates of 35 g/hour.  For example, in this system, boron powder is introduced to a directed flow of plasma and boron nitride nanostructures are formed in a chamber. This system can produce collapsed BN nanotubes (nanoribbons) and closed shell BN capsules (nanococoons).  The system is also adaptable to a large variety of feedstock materials.

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