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A Micro/Nanobubble Oxygenated Solutions for Wound Healing and Tissue Preservation

Soft-tissue injuries and organ transplantation are common in modern combat scenarios. Organs and tissues harvested for transplantation need to be preserved during transport, which can be very difficult. Micro and nanobubbles (MNBs) offer a new technology that could supply oxygenation to such tissues prior to transplantation, thus affording better recovery and survival of patients. Described here is a novel device capable of producing MNB solutions that can be used to preserve viability and function of such organs/tissue. Additionally, these solutions may be used with negative pressure wound therapy to heal soft-tissue wounds.

Enhanced Fluorescence Readout And Reduced Inhibition For Nucleic Acid Amplification Tests

UCLA researchers in the Department of Bioengineering have developed an enhanced fluorescent detection method for nucleic acid amplification tests.

New 3D-Exoquant Method For The Analysis Of Surface Molecules And Quantification Of Tissue-Specific Exosomes In Biological Fluids

UCLA researchers in the Department of Neurology have developed a novel high sensitivity exosome and extracellular vesicle disease detection technology for use in the clinical and research setting. 

Remotely-Activated Cell Therapy

The remote control of cellular activation in a controllable and reproducible fashion is a key tool for biological research, as well as for therapeutic uses. Cellular therapies are becoming well established within the medical community. However, the degree of cellular activation can be an unknown factor, and the risk of off-target effects remains. Cells may be delivered, but may not be therapeutically effective, or effective cells may elicit activity in an undesired location. The delivery of a cell therapy where a known quantity of cell activation occurs at a specific, selected site may therefore be advantageous. UC San Diego researchers have recently developed the methods and materials for remote control of cellular activation, to dynamically manipulate molecular events for therapeutic effect.

Nanoparticle-Loaded Cellular Delivery System of Pt(II) Chemotherapeutic Drugs

Major challenges of treating ovarian carcinomas by the use of intraperitoneal (IP) chemotherapy (e.g. injecting chemo drugs into the abdominal cavity through a catheter) include how to retain the drug in the cavity for longer periods of time, how to concentrate it onto the tumor nodules growing on the peritoneal surface, and how to enhance its penetration from the free surface of the nodule. Drug loaded nanomaterials are generally obtained by encapsulation of the drug during formulation of the particle via non‐covalent adsorption or passive entrapment. A limitation of these loading strategies is the burst release of drug, where an important fraction of the loaded compound is released in a short amount of time due to the inherently weak forces keeping the drug associated with the nanocarrier. In addition, for metal based drugs, loaded polymeric nanomaterials can be generated via a post‐polymerization reaction of an activated metal complex with an activated ligand moiety on the polymer backbone. In this case, inherent to the technique, is the lack of control of the type of ligand (monodentate, bidentate) and complex (interstrand or intrastrand), which are obtained. However, the main drawback to these approaches is the typically low and uncontrolled encapsulation efficacy, which is a severe limitation for large‐scale production and reproducibility that hinders the development of clinically appropriate formulations.

An Aza-Diels-Alder Approach To Polyquinolines

The invention is a simple and inexpensive synthetic approach to a diverse library of new polymeric materials with a host of useful and unique properties. Most notably, these materials can serve as precursors to rationally designed and bottom-up synthesized graphene nanoribbons (GNRs), including N-doped GNRs and GNRs with precisely defined and functionalized edges.

Sensitive, Specific Ratiometric Fluorescence-based DNA Detection

Fluorescent silver nanoclusters for nucleic acid detection. 

Cell Membrane-cloaked Nanofibers Promote Cell Proliferation and Function

Cloaking of synthetic structures with natural cell membranes has emerged as an intriguing strategy for presenting natural cell surface antigens and functions in the context of synthetic compositions with designed functions. Early forays into the field focused primarily on the development of cell membrane-coated spherical nanoparticles. While a boon to material sciences, such spherical structures cannot address the full spectrum of potential applications and the application of cell membrane cloaking techniques to nanofibers enables drastically different characteristics and applications.

3D Printed Artificial Micro-Fish

With recent advances in nanoscience and nanomanufacturing technologies, the areas of biomimetic micro-robotics and nanomotors have seen rapid development in realizing functionalities mimicking natural organisms with self-propulsion. The capability to fabricate complex architectures and miniaturize the dimension is highly desired for designing and customizing more functionalized, integrated and intelligent micromachines for different applications. In light of these challenges, rapid 3D optical printing offers a promising alternative for efficiently manufacturing controllable microswimmers with complex 3D microscale structures composed of patterned heterogeneous materials as well as different functional components.

LIPOSOMAL POROUS SILICON NANOPARTICLES AS A GENE DELIVERY SYSTEM

Gene delivery systems for in vivo therapeutics remain a challenge due to low efficiency or cytotoxicity. Celllular endocytosis is the primary uptake pathway of most nanoplatforms, which results in lysosomal degradation of genetic material and low therapeutic efficacy.

A New Methodology For 3D Nanoprinting

Researchers at the University of California, Davis have discovered a novel protocol to enable 3D printing with nanometer precision in all three dimensions using polyelectrolyte (PE) inks and atomic force microscopy.

Nanoporphyrin Nanoparticles for Combination Phototherapy and Drug Delivery to Infantile Hemangiomas

Researchers at the University of California Davis have developed a novel treatment method that combines photodynamic therapy and the therapeutic compound propranolol using a nanoparticle platform to treat infantile hemangiomas (IH).

X-Ray-Triggered Release of Drugs from Nanoscale Drug Carriers

Researchers at the University of California, Davis have identified a means by which large quantities of inactive drugs (particularly chemotherapeutics) can be delivered by nanoscale drug carriers to a target location where they can be rendered active by X-rays.

UCLA Inventors Create Platform Technology to Create Customizable Nanoscale Particles and Gels for Use in the Industrial Biomaterials Market

UCLA researchers in the Departments of Chemistry, Physics, and Bioengineering, led by Dr. Tim Deming of the Bioengineering department, have developed a platform to create and modify nanoscale particles and gels for use in the industrial biomaterials market. The polypeptide based delivery vehicle platforms created by the Deming group are customizable in nearly all physical characteristics, can be tailored in size, loaded with hydrophobic and hydrophilic payloads, used in coatings, are fully synthetic, possess highly reproducible properties, and are inexpensive to prepare compared to solid-phase peptide synthesis.The platform can be used to create novel, need-based nanoscale vesicles or injectable hydrogels, and can also be used to augment existing materials systems.

UCLA Inventors Create Platform Technology to Create Customizable Nanoscale Wound Management Tools

UCLA researchers in the Departments of Chemistry, Physics, and Bioengineering, led by Dr. Tim Deming of the Bioengineering department, have developed a platform to create and modify nanoscale vesicles and hydrogels for use in wound management. The poly-peptide based platforms created by the Deming group are customizable in nearly all physical characteristics, can be tailored in size, be loaded with hydrophobic, hydrophilic, or cellular payloads, adaptable to specific delivery locations, low toxicity, are fully synthetic, possess highly reproducible properties, and are inexpensive to prepare compared to solid-phase peptide synthesis. The platform can be used to create novel, need-based nanoscale vesicles or injectable hydrogels, and can be used to augment existing material systems.

UCLA Inventors Create Platform Technology to Create Customizable Nanoscale Particles and Gels for Use in the Industrial Biomaterials Market

UCLA researchers in the Departments of Chemistry, Physics, and Bioengineering, led by Dr. Tim Deming of the Bioengineering department, have developed a platform to create and modify nanoscale particles and gels for use in the industrial biomaterials market. The polypeptide based delivery vehicle platforms created by the Deming group are customizable in nearly all physical characteristics, can be tailored in size, loaded with hydrophobic and hydrophilic payloads, used in coatings, are fully synthetic, possess highly reproducible properties, and are inexpensive to prepare compared to solid-phase peptide synthesis.The platform can be used to create novel, need-based nanoscale vesicles or injectable hydrogels, and can also be used to augment existing materials systems.

UCLA Inventors Create Platform Technology to Create Customizable Nanoscale Drug Delivery Materials

UCLA researchers in the Departments of Chemistry, Physics, and Bioengineering, led by Dr. Tim Deming of the Bioengineering department, have developed a platform to create and modify nanoscale drug delivery particles. The poly-peptide based platforms created by the Deming group are customizable in nearly all physical characteristics, can be tailored in size, loaded with hydrophobic and hydrophilic payloads, adaptable to specific delivery locations, low toxicity, are fully synthetic, possess highly reproducible properties, and are inexpensive to prepare compared to solid-phase peptide synthesis.The platform can be used to create novel, need-based nanoscale vesicles or injectable hydrogels, and can also be used to augment existing nanoparticle systems.

UCLA Inventors Create Platform Technology to Create Customizable Materials for Imaging and Detection

UCLA researchers in the Departments of Chemistry, Physics, and Bioengineering, led by Dr. Tim Deming of the Bioengineering department, have developed a platform to create and modify nanoscale vesicles and hydrogels for use in imaging and detection.The poly-peptide based platforms created by the Deming group are customizable in nearly all physical characteristics, can be tailored in size, be loaded with hydrophobic and hydrophilic payloads, adaptable to specific delivery locations, low toxicity, are fully synthetic, possess highly reproducible properties, and are inexpensive to prepare compared to solid-phase peptide synthesis.The platform can be used to create novel, need-based nanoscale vesicles or injectable hydrogels, and can also be used to augment existing nanoparticles.

Process for the Fabrication of Nanostrucured Arrays on Flexible Polymer Films

The technology is a process for making arrays of nanostructures on polymer films.It features a two step process for creating thin polymer films with unique optical and wetting properties that can be used for coating both planar and curved surfaces.It is possible to implement this process in a mass fabrication process over large areas.

Novel Multivalent Bioassay Reagents

The guiding principle for the creation of biomolecular recognition agents has been that affinity is essential for both strength and specificity.  Monoclonal antibodies, the dominant workhorse of affinity reagents, have mono-valent affinities in the uM-nM range with apparent affinities that can be sub nM with the bi-valency intrinsic in intact immunoglobulin structure.  The avidin-biotin interaction used ubiquitously for biomolecular assembly is femto-molar and both highly specific and essentially irreversible.  High affinity has been proclaimed the essential goal for the selection of useful specific aptamers, though there has been disagreement about a tight coupling of affinity and specificity.  

Activating HIV Latency Using Drug Encapsulated Nanoparticles

UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have devised a novel method to target the HIV virus in patients using nanoparticles loaded with therapeutic agents.

Self-Assembled Modified Beta Solenoid Protein Scaffolds for Devices And Materials

Available for licensing are patent rights in novel and versatile beta solenoid proteins that are useful as scaffolds for nanoparticle assembly, photocatalytic devices, thermoelectric devices, passive absorption of small atoms or molecules, cement additive, heavy element remediation, heavy element absorption, and as biological catalysts.

Imprinted Polymer Nanoparticles

Synthetic polymer nanoparticles (NPs) capable of recognizing specific biomacromolecules and can be used as substitutes for natural antibodies .

Stimuli-Sensitive Intrinsically Disordered Protein Brushes

Recent advances in biomedicine and biotechnology are driving the demand for novel surface functionalization platforms for biologically active molecules. Polymer brush coatings form when macromolecular chains are end-tethered to surfaces at high grafting densities. While there have been notable successes integrating polymer brush coatings with proteins to control biological function, such strategies require covalent conjugation of the protein to the polymer, which can be inefficient and can compromise biological function. Moreover, these polymer brushes almost universally feature synthetic polymers, which are often heterogeneous and do not readily allow incorporation of chemical functionalities at precise sites along the constituent chains. To address these challenges, Researchers at the University of California, Berkeley (UCB) conducted experiments with polymer brushes based on nerve cell neurofilaments as the intrinsically disordered protein (IDP). By cloning a portion of a gene that encodes one of the neurofilament bristles, and re-engineering it such that they could attach the resulting protein to surfaces, UCB investigators have developed a biomimetic, recombinant IDP that can assemble into an environment-sensitive protein brush that swells and collapses dramatically with environmental changes in solution pH and ionic strength. Their research demonstrates that stimuli-responsive brushes can be efficiently integrated with proteins without compromising biological function, which could have broad commercial appeal as a new class of smart biomaterial building blocks.

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