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Method and System for Ultra High Dynamic Range Nucleic Acid Quantification

Researchers at UC Irvine developed a device and method that combines the high dynamic range and high accuracy of digital PCR (dPCR) with the real-time analysis of quantitative PCR (qPCR) to achieve a ultra-high dynamic range PCR over 10 to 12 orders of magnitude. The present method is accomplished by a highly integrated design that optimally packs, thermocycles, and images as many as 1 million reaction vessels.

Nanowire Building Block

Nanowires have applications as transistors or bioelectronic devices. Current methods to synthesize nanowires lack the ability to precisely control length, sequence, and terminal functionality. Using this invention as a building block, organic nanowires can be made with controlled length, sequence, and terminal functionality. The organic nanowires made with this invention also exhibit zero-resistance and do not degrade with increased length.

Soluble Fluorescent DNA Label

Assays or biosensors that utilize electrochemical or fluorescent techniques often employ DNA electrochemical probes. Current probes have drawbacks, as they have either electronic or fluorescent properties, are not readily water-soluble, and are poorly coupled within a DNA strand. This invention is a DNA electrochemical probe that has both electronic and fluorescent properties, is water-soluble, and can readily incorporate into a DNA strand.

Growth-Factor Nanocapsules With Tunable Release Capability For Bone Regeneration

UCLA researchers in the Departments of Chemical Engineering and Orthopedic Surgery have developed a method to deliver therapeutic proteins directly to the tumor site using nanocapsules.

High Performance and Flexible Chemical And Bio Sensors Using Metal Oxide Semiconductors

UCLA researchers in the Department of Materials Science and Engineering have developed a simple method producing thin, sensitive In2O3-based conformal biosensors based on field-effect transistors using facile solution-based processing for future wearable human technologies as well as non-invasive glucose testing.

Protein Nanocapsules With Detachable Zwitterionic Coating For Protein Delivery

UCLA researchers in the Department of Chemical and Biomolecular Engineering have developed a method to deliver therapeutic proteins directly to the tumor site using nanocapsules.

Evaporation-Based Method For Manufacturing And Recycling Of Metal Matrix Nanocomposites

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a new method to manufacture and recycle metal matrix nanocomposites.

New Method to Increase the Rate of Protein Ligation Catalyzed by the S. Aureus Sortase A Enzyme

UCLA researchers in the Department of Chemistry and Biochemistry have developed a new method to increase the rate of ligation catalyzed by the S. aureus Sortase A enzyme

PVA nanocarrier system for controlled drug delivery

Researchers at the University of California, Davis have designed and synthesized a unique type of water-soluble, biodegradable targeting poly(vinyl alcohol) (PVA) nanocarrier system for controlled delivery of boronic acid containing drugs, chemotherapy agents, proteins, photodynamic therapy agents and imaging agents.

Artificial cornea implant using nanopatterned synthetic polymer

The device is an artificial corneal implant comprised of a single, nanopatterned material. The device is durable, easy to implant, and robust against bacterial infection and other problems associated with other state-of-the-art ocular devices.

Ultra Light Amphiphilic And Resilient Nanocellulose Aerogels And Foams

Researchers at the University of California, Davis have developed an energy efficient method of producing ultra-light aerogels with excellent dry compressive strength and tunable hydrophobicity by ambient drying of nanocellulose wet gels.

A Micro/Nanobubble Oxygenated Solutions for Wound Healing and Tissue Preservation

Soft-tissue injuries and organ transplantation are common in modern combat scenarios. Organs and tissues harvested for transplantation need to be preserved during transport, which can be very difficult. Micro and nanobubbles (MNBs) offer a new technology that could supply oxygenation to such tissues prior to transplantation, thus affording better recovery and survival of patients. Described here is a novel device capable of producing MNB solutions that can be used to preserve viability and function of such organs/tissue. Additionally, these solutions may be used with negative pressure wound therapy to heal soft-tissue wounds.

Enhanced Fluorescence Readout And Reduced Inhibition For Nucleic Acid Amplification Tests

UCLA researchers in the Department of Bioengineering have developed an enhanced fluorescent detection method for nucleic acid amplification tests.

New 3D-Exoquant Method For The Analysis Of Surface Molecules And Quantification Of Tissue-Specific Exosomes In Biological Fluids

UCLA researchers in the Department of Neurology have developed a novel high sensitivity exosome and extracellular vesicle disease detection technology for use in the clinical and research setting. 

Remotely-Activated Cell Therapy

The remote control of cellular activation in a controllable and reproducible fashion is a key tool for biological research, as well as for therapeutic uses. Cellular therapies are becoming well established within the medical community. However, the degree of cellular activation can be an unknown factor, and the risk of off-target effects remains. Cells may be delivered, but may not be therapeutically effective, or effective cells may elicit activity in an undesired location. The delivery of a cell therapy where a known quantity of cell activation occurs at a specific, selected site may therefore be advantageous. UC San Diego researchers have recently developed the methods and materials for remote control of cellular activation, to dynamically manipulate molecular events for therapeutic effect.

Nanoparticle-Loaded Cellular Delivery System of Pt(II) Chemotherapeutic Drugs

Major challenges of treating ovarian carcinomas by the use of intraperitoneal (IP) chemotherapy (e.g. injecting chemo drugs into the abdominal cavity through a catheter) include how to retain the drug in the cavity for longer periods of time, how to concentrate it onto the tumor nodules growing on the peritoneal surface, and how to enhance its penetration from the free surface of the nodule. Drug loaded nanomaterials are generally obtained by encapsulation of the drug during formulation of the particle via non‐covalent adsorption or passive entrapment. A limitation of these loading strategies is the burst release of drug, where an important fraction of the loaded compound is released in a short amount of time due to the inherently weak forces keeping the drug associated with the nanocarrier. In addition, for metal based drugs, loaded polymeric nanomaterials can be generated via a post‐polymerization reaction of an activated metal complex with an activated ligand moiety on the polymer backbone. In this case, inherent to the technique, is the lack of control of the type of ligand (monodentate, bidentate) and complex (interstrand or intrastrand), which are obtained. However, the main drawback to these approaches is the typically low and uncontrolled encapsulation efficacy, which is a severe limitation for large‐scale production and reproducibility that hinders the development of clinically appropriate formulations.

An Aza-Diels-Alder Approach To Polyquinolines

The invention is a simple and inexpensive synthetic approach to a diverse library of new polymeric materials with a host of useful and unique properties. Most notably, these materials can serve as precursors to rationally designed and bottom-up synthesized graphene nanoribbons (GNRs), including N-doped GNRs and GNRs with precisely defined and functionalized edges.

Finite-State Machines For DNA Information Storage

DNA can store petabytes of information per gram and can last intact for tens of thousands of years.  This makes it an appealing prospect for long-term archival storage.  However, DNA synthesis, sequencing, and replication are prone to errors, which limit its potential as a storage medium.  These errors can be controlled by applying the tools of information theory, treating DNA storage as a noisy channel coding problem.  Several coding schemes for DNA storage have been proposed that address the interrelated issues of error avoidance, error correction and redundancy.  There are currently no schemes that address all the above.    Researchers at UC Berkeley have combine some of these ideas, and introduced new ones, using a modular strategy for code design.  With this method, codes can be assembled to meet requirements including error-avoidance, error-correction (resistant to corruption of the information by substitutions, insertions, duplications, or deletions that are introduced during sequencing or replication of the DNA), and demarcation of metadata.  The DNA generated by the codes is free of short local repeats and other (foldback) structure.  The codes generated by this method are flexible in that they arise by systematic combination of state machines, each machine formally representing a particular transformation of the input sequence.  So, for example, one state machine might be used to introduce a "watermark" signal that helps protect against insertion/deletion errors; another state machine could be used to convert the binary sequence into a ternary sequence (or mixed-radix sequence); another state machine would convert the ternary or mixed-radix sequence into a non-repeating DNA sequence; and another state machine to model the errors that are introduced during sequencing. 

Sensitive, Specific Ratiometric Fluorescence-based DNA Detection

Fluorescent silver nanoclusters for nucleic acid detection. 

Cell Membrane-cloaked Nanofibers Promote Cell Proliferation and Function

Cloaking of synthetic structures with natural cell membranes has emerged as an intriguing strategy for presenting natural cell surface antigens and functions in the context of synthetic compositions with designed functions. Early forays into the field focused primarily on the development of cell membrane-coated spherical nanoparticles. While a boon to material sciences, such spherical structures cannot address the full spectrum of potential applications and the application of cell membrane cloaking techniques to nanofibers enables drastically different characteristics and applications.

3D Printed Artificial Micro-Fish

With recent advances in nanoscience and nanomanufacturing technologies, the areas of biomimetic micro-robotics and nanomotors have seen rapid development in realizing functionalities mimicking natural organisms with self-propulsion. The capability to fabricate complex architectures and miniaturize the dimension is highly desired for designing and customizing more functionalized, integrated and intelligent micromachines for different applications. In light of these challenges, rapid 3D optical printing offers a promising alternative for efficiently manufacturing controllable microswimmers with complex 3D microscale structures composed of patterned heterogeneous materials as well as different functional components.


Gene delivery systems for in vivo therapeutics remain a challenge due to low efficiency or cytotoxicity. Celllular endocytosis is the primary uptake pathway of most nanoplatforms, which results in lysosomal degradation of genetic material and low therapeutic efficacy.

A New Methodology For 3D Nanoprinting

Researchers at the University of California, Davis have discovered a novel protocol to enable 3D printing with nanometer precision in all three dimensions using polyelectrolyte (PE) inks and atomic force microscopy.

Nanoporphyrin Nanoparticles for Combination Phototherapy and Drug Delivery to Infantile Hemangiomas

Researchers at the University of California Davis have developed a novel treatment method that combines photodynamic therapy and the therapeutic compound propranolol using a nanoparticle platform to treat infantile hemangiomas (IH).

X-Ray-Triggered Release of Drugs from Nanoscale Drug Carriers

Researchers at the University of California, Davis have identified a means by which large quantities of inactive drugs (particularly chemotherapeutics) can be delivered by nanoscale drug carriers to a target location where they can be rendered active by X-rays.

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