Controlling the structure and organization of electrospun fiber is desirable for fabricating scaffolds and materials with precise microstructures for use in textile, filtering materials, wound healing, drug delivery, and tissue engineering. Manufacturing by electrospinning templates for controlling the microstructure architecture is inherently complicated and non-dynamic, and typically slow and expensive. Moreover, conventional electrospinning techniques are prone to mechanical instabilities, including distortion, shrinkage, and delamination or pore collapse. To help solve these problems, researchers at Berkeley created methods and technology to control fiber deposition in electrospinning using unique microfabrication means. In one instance, investigators performed an animal study with electrospun scaffolds to assess collagen deposition in histologic cross sections of spun scaffolds. Early data results related to the new materials and structures suggest superior fiber organization, porosity, biocompatibility, and biological performance properties, which may have broad industrial applications, from materials microfabrication to clinical therapies.