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Nanomotor Photolithography

The rapid miniaturization of devices and machines has fueled the evolution of advanced fabrication techniques. However, current technologies of nanopatterning are still limited by the resolution of the pattern, the major cost of implementation, range of patterns that can be written, the patterning speed as well as the environment where such a technique can be used. The complexity and high cost of state-of-the-art high-resolution lithographic systems have prompted unconventional routes for nanoscale patterning. Inspired by the sophistication of natural nanomachines, synthetic nanomotors have recently demonstrated remarkable performance and functionality.

Process for the Fabrication of Nanostrucured Arrays on Flexible Polymer Films

The technology is a process for making arrays of nanostructures on polymer films.It features a two step process for creating thin polymer films with unique optical and wetting properties that can be used for coating both planar and curved surfaces.It is possible to implement this process in a mass fabrication process over large areas.

Novel Multivalent Bioassay Reagents

The guiding principle for the creation of biomolecular recognition agents has been that affinity is essential for both strength and specificity.  Monoclonal antibodies, the dominant workhorse of affinity reagents, have mono-valent affinities in the uM-nM range with apparent affinities that can be sub nM with the bi-valency intrinsic in intact immunoglobulin structure.  The avidin-biotin interaction used ubiquitously for biomolecular assembly is femto-molar and both highly specific and essentially irreversible.  High affinity has been proclaimed the essential goal for the selection of useful specific aptamers, though there has been disagreement about a tight coupling of affinity and specificity.  

Activating HIV Latency Using Drug Encapsulated Nanoparticles

UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have devised a novel method to target the HIV virus in patients using nanoparticles loaded with therapeutic agents.

Self-Assembled Modified Beta Solenoid Protein Scaffolds for Devices And Materials

Available for licensing are patent rights in novel and versatile beta solenoid proteins that are useful as scaffolds for nanoparticle assembly, photocatalytic devices, thermoelectric devices, passive absorption of small atoms or molecules, cement additive, heavy element remediation, heavy element absorption, and as biological catalysts.

Imprinted Polymer Nanoparticles

Synthetic polymer nanoparticles (NPs) capable of recognizing specific biomacromolecules and neutralizing their activities can be used as substitutes for natural antibodies.

Stimuli-Sensitive Intrinsically Disordered Protein Brushes

Recent advances in biomedicine and biotechnology are driving the demand for novel surface functionalization platforms for biologically active molecules. Polymer brush coatings form when macromolecular chains are end-tethered to surfaces at high grafting densities. While there have been notable successes integrating polymer brush coatings with proteins to control biological function, such strategies require covalent conjugation of the protein to the polymer, which can be inefficient and can compromise biological function. Moreover, these polymer brushes almost universally feature synthetic polymers, which are often heterogeneous and do not readily allow incorporation of chemical functionalities at precise sites along the constituent chains. To address these challenges, Researchers at the University of California, Berkeley (UCB) conducted experiments with polymer brushes based on nerve cell neurofilaments as the intrinsically disordered protein (IDP). By cloning a portion of a gene that encodes one of the neurofilament bristles, and re-engineering it such that they could attach the resulting protein to surfaces, UCB investigators have developed a biomimetic, recombinant IDP that can assemble into an environment-sensitive protein brush that swells and collapses dramatically with environmental changes in solution pH and ionic strength. Their research demonstrates that stimuli-responsive brushes can be efficiently integrated with proteins without compromising biological function, which could have broad commercial appeal as a new class of smart biomaterial building blocks.

Bioactive Tissue Engineering Scaffolds

Brief description not available

Regionally Activated Drug Delivery Nanoparticles

A major challenge facing nanoparticle-based drug delivery vehicles with chemotherapy payloads is accumulation in healthy tissue through passive extravasation as well as active uptake by the reticulo-endothelial system. These healthy tissues get a dose of the active drug once the nanoparticles begin to break down resulting in dose limiting side effects. New approaches and platforms are needed to address this issue.

Stimuli Responsive Based Digital Biosensors For The Measurement Of Oxidative Stress

Oxidative stress and reactive oxygen species (ROS) are the hallmarks of many disorders, including drug-associated toxicity, atherosclerosis, cancer, and degenerative processes associated with aging. Routine monitoring of circulating ROS in a point-of-care (POC) manner would reduce morbidity and mortality. However, current methods for measuring oxidative stress and lipid peroxidation rely on label-based fluorescence transduction methods for optical detection. This is laborious, lengthy and requires accurate optical instrumentation. It is also expensive and difficult to miniaturize, making it impractical for POC use in low-resource settings. Developing electrochemical biosensors for POC applications has been challenging due to the difficulties in combining the query biomolecule receptor with an electrical transducer to produce an electrical signal in presence of the query biomolecule for a simple, accurate and inexpensive platform for patient diagnosis.Investigators at UC Berkeley have met this challenge with the ROSchip innovation. ROSchip is an oxidative stress digital biosensor, a lab-on-a-chip device which has a novel stimuli responsive polymer for early detection of circulating ROS in blood. The ROSchip’s data provides accurate management of cardiovascular and atherosclerosis diseases in routine clinical practices. Circulating lipid hydroperoxides (LPH), the primary biomarkers of lipid oxidation, predict cardiovascular events in patients with a history of cardiovascular disease. The ROSchip provides accurate, cost-effective, and fast assessment and monitoring of LPH. The ROSchip system is designed with interdigitated electrodes coated with a thin film of ROS-responsive polymer. The ROS generates an electrical signal indicating LPH present in a sample. 

Novel Chitosan Derivative as a Systemic Drug Delivery Agent and an Antibiotic Treatment

Researchers at the University of California, Irvine have developed a novel chitosan derivative that may be used simultaneously as a systemic drug delivery agent and a systemic antibiotic treatment.

Noise Reduction for DNA and Other Macromolecules Sequencing Using Oversampling and Cross-Correlations

Sequencing of macromolecules and especially of DNA is an extremely important area for biology, medicine and pharmacology. Developing realistic inexpensive methods for sequencing is becoming a crucial area for research and technological development. Current alternatives to standard PCR sequencing methods use serial physical property measurements. The key problem with these methods is that they are very susceptible to a large number of noise sources, which make their use problematic, perhaps impossible. Therefore development of a noise reduction scheme becomes imperative.

Single-Molecular Homogenous Amplified Detection in Confined Volumes

This novel method detects the concentration of molecules of interest without washing steps or any solid-phase reaction.

Methods for Electrospun Fibrous Scaffolds

Controlling the structure and organization of electrospun fiber is desirable for fabricating scaffolds and materials with precise microstructures for use in textile, filtering materials, wound healing, drug delivery, and tissue engineering. Manufacturing by electrospinning templates for controlling the microstructure architecture is inherently complicated and non-dynamic, and typically slow and expensive. Moreover, conventional electrospinning techniques are prone to mechanical instabilities, including distortion, shrinkage, and delamination or pore collapse. To help solve these problems, researchers at Berkeley created methods and technology to control fiber deposition in electrospinning using unique microfabrication means. In one instance, investigators performed an animal study with electrospun scaffolds to assess collagen deposition in histologic cross sections of spun scaffolds. Early data results related to the new materials and structures suggest superior fiber organization, porosity, biocompatibility, and biological performance properties, which may have broad industrial applications, from materials microfabrication to clinical therapies.

System And Methods For Fabricating Boron Nitride Nanostructures

A research team led by Alex Zettl has developed a variable pressure, powder/gas/liquid injection inductively coupled plasma system that is used to produce high quality boron nitride nanotubes (BNNTs) at continuous rates of 35 g/hour.  For example, in this system, boron powder is introduced to a directed flow of plasma and boron nitride nanostructures are formed in a chamber. This system can produce collapsed BN nanotubes (nanoribbons) and closed shell BN capsules (nanococoons).  The system is also adaptable to a large variety of feedstock materials.

Fully Alloyed Silver and Gold Nanostructures

Background: Biomolecular imaging is important in understanding characteristics of molecules and analyzing quantitative  data for research. Gold has been used for Surface Plasmon Resonance (SPR) which is utilized  for biomolecular imaging. Because of Gold’s high stability structurally and chemically, it is resourceful in this sort of technology.  Compared to Gold, Silver does not have as strong of a stability in non ideal chemical environments, but has high reactivity, supports strong surface plasmon polarization modes, and has higher storage of electrical energy than Gold.Description: UCR researchers have created Silver-Gold  alloy nanospheres through annealing techniques which may be used in SPR that creates optimal and effective results.  By annealing the Silver and Gold metal alloy, it has shown remarkable stability in harsh chemical environments, extremely narrow bandwidths, and shows large extinction pathways. These  specific characteristics enable many plasmonic applications with high performance and long lifetime, especially any involving corrosive species making the Silver-Gold alloy the most favorable choice for SPR.

Targeting Peptides for Improved Pharmacokinetics and In Vivo Stability

Researchers at the University of California, Davis have developed peptides that target αvβ6 integrin and show promise for imaging and therapeutic applications in a variety of diseases.  These peptides have been designed to optimize pharmacokinetics and target specificity.

Synthetic Platelets (SynPlats) to Treat Internal & External Bleeding

      Biomaterial nano-particles that mimic the key structural and functional attributes of platelets and have been shown to greatly reduce bleeding time both internally and externally.

On-Demand Drug Release System for In Vivo Cancer Treatment Via Self-Assembled Magnetic Nanoparticles

Researchers at UCLA have utilized magnetothermally responsive self-assembled nanoparticle technology for highly effective in vivo cancer treatment. The present invention will lead to a more personalized and effective approach in the field of cancer treatment.

Method of Making Multicomponent Nanoemulsions

Researchers from UCLA’s Department of Chemistry & Biochemistry have developed a novel method of making deformable, multicomponent oil-in-water nanoemulsions to create a single delivery system for multiple drugs or other insoluble molecules.  

Phage Wrapping to Enhance Sensitivity of Novel Phage Nanowire Biosensors

The Weiss and Penner labs at the University of California, Irvine have developed a portfolio of technologies based on M13 bacteriophage viruses that have successfully been incorporated into nanowire arrays. The resulting label-free phage-based biosensors allow direct electrical resistance measurements to quickly detect low concentrations of target analytes. Recently the Weiss and Penner labs have developed a unique combination of molecules used to wrap the phage to enhance and exploit the aforementioned phage-based biosensors. This unique combination of molecules decreases non-specific binding to phages and increases the sensitivity and signal-to-noise of the phage-based biosensors.

Assessing the Toxic Potential of Materials at the Nanolevel

UCLA researchers in the Department of Medicine have developed a comprehensive cellular toxicological screening protocol to speed up the evaluation and hazard ranking of large categories of engineered nanomaterials; this methodology can also be adapted to perform high throughput screening of redox active nanomaterials with the potential to build predictive toxicological paradigms for regulatory purposes.

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