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Microchambers With Solid-State Phosphorescent Sensor For Measuring Single Mitochondrial Respiration

The invention is a miniaturized device that assays the respiration of a single mitochondrion. Through a novel approach for measuring oxygen consumption rate, the device provides information on cell and tissue mitochondrial functional. This data is relevant for understanding human conditions associated with mitochondrial dysfunction, such as Alzheimer’s Disease and cancer.

Engineering the protein corona of a synthetic polymer nanoparticle for broad-spectrum sequestration and neutralization of venomous biomacromolecules

Antivenoms are created by harvesting antibodies from surrogate animals that are exposed to small amounts of specific venom. This process is very costly and sometimes ineffective due to variations even within a single species. The inventors at UCI have developed a broad spectrum antivenom using nanoparticles which absorb and sequester key proteins in the venom.

A Therapeutic Bandage For Treating Venom-Induced Tissue Necrosis

Snakebites affect 4.5 million people a year. Treatments that could save victim’s lives require capable medical facilities, which are not always within reach. Researchers at UCI have developed a therapeutic bandage for treating the tissue necrosis associated with snake bites. The invention can be applied in the field and has the potential to save many lives.

Proteomic Chip for determining immune status and prognosis of HIV patients

Researchers at UCI have developed a multi-clade HIV-1 proteomic chip that helps with diagnosis of clade specific infection of HIV-1. Proteomic chip can determine the immune status and prognosis of HIV infected individuals.

Improved Cell-Free Protein Synthesis For Protein Microarray

Researchers at UC Irvine have developed a cell-free (CF) protein synthesis system to solubilize and synthesize highly hydrophobic membrane proteins that would typically aggregate using current CF synthesis systems. With such high amounts of synthesized proteins, researchers intend to build protein microarrays for diagnostic purposes.

Enhanced Cell/Bead Encapsulation Via Acoustic Focusing

The invention consists of a multi-channel, droplet-generating microfluidic device with a strategically placed feature. The feature vibrates in order to counteract particle-trapping micro-vortices formed in the device. Counteracting these vortices allows for single particle encapsulation in the droplets formed by the device and makes this technology a good candidate for use in single cell diagnostics and drug delivery systems.

Chiral Polymers Of Intrinsic Microporosity For Membrane Separation Of Enantiomers

Many pharmaceutical drugs exist as enantiomeric pairs, chemically-distinct mirror image of one another that often exhibit marked differences in biological activity. Current methods for separating enantiomeric mixtures to generate pure form of an effective drug involve multiple time-consuming and expensive steps. The invention herein describes a polymer that can selectively separate enantiomers in a simple, continuous process.

microfluidic device for preparation of monodisperse microcapsules and microvesicles

Many applications, ranging from in vivo cell culture growth to drug delivery, rely on microcapsules to encapsulate and protect cells or molecules until their desired release. These microcapsules are typically generated in immiscible fluid, which must be depleted before they can be effectively used. Researchers at UCI have recently developed a paper-based microcapsule extraction technique that is quicker, cheaper, and less damaging than conventional methods.

Synthetic polymer nanoparticle hydrogels for drug screening

Synthetic polymer nanoparticle hydrogels and polymers can be designed to interact with and sequester targeted bio-macromolecules such as proteins, peptides, and carbohydrates. These relatively inexpensive and target specific polymers could potentially replace current antibody therapies and protein purification procedures.

Continuous, enhanced detection of droplet contents in electrical impedance spectroscopy

The inventors at UCI have developed a method and system to make enhanced electrical impedance spectroscopy measurements in a continuously flowing train of microfluidic droplets. The technique increases the sensitivity of the electrical impedance spectroscopy measurements, lowering detection limits and increasing the frequency of continuous measurements.

Slap Band Vitals Monitor

The invention is an easy to use wristband that continuously monitor various vitals like the heart rate, temperature and blood pressure. It eliminates the need for uncomfortable and bulky cuffs that are normally used for such measurements. The wristband communicates wirelessly to the user’s or doctor’s smart phone for easy access, monitoring and care.

Patterning Silica Islands Onto Thermoplastic Shrink Film

Biosensors have a variety of applications from glucose monitoring to drug discovery. The ability to detect low concentration of analytes in biological samples is important for creating effective biosensors. Researchers at UCI have developed a novel lithographic method for capturing, concentrating, and identifying biological agents.

Highly Wrinkled Metal Thin Films Using Lift-Off Layers

Wearable electronics are becoming a popular way of integrating personal healthcare with continuous, remote health monitoring, yet current devices are bulky and exhibit poor electronic performance. Wrinkled metal thin films can be utilized for their thin, flexible profiles, which conform well to the skin. Researchers at UCI have developed a novel method using specialized materials that results in wrinkled metal thin films that have enhanced mechanical and electrical performance.

Methods For Diagnostic Techniques And Diagnosis Of Multiple Sclerosis, Autoimmune Disorders And Diseases Related To Glycan Dysregulation

Certain diseases, such as Multiple Sclerosis and other autoimmune disorders, are associated with deficiencies in specific metabolites that influence protein glycosylation. This invention is a specialized method to detect levels of these metabolites, which can then be used to diagnose disorders and guide personalized treatments.

Functional Monitoring Of Contracting Cells Using Post Motion Vectors Analysis Algorithms

The characterization of the contractile behavior of heart cells is very important, especially as an in vitro drug-screening method. Some important behaviors of cardiomyocytes can only be measured with very expensive equipment. Researchers at UCI have developed software capable of characterizing contracting cells effectively and inexpensively.

Reduced IP3 Signaling As A Diagnostic Tool For Autism Spectrum Disorders

The diagnosis of Autism Spectrum Disorder (ASD), and thus the development of therapies, is very challenging due to the lack of objective criteria and biomarkers. It is, however, a disease with a strong genetic component, and recent data has implicated new genes in the disease. Researchers at UC Irvine have developed a method to more reliably diagnose ASD with a laboratory test.

A non-destructive method of quantifying mRNA in a single living cell

The detection of levels of messenger RNA (mRNA), the molecule used by DNA to convey information about protein production, is a very important method in molecular biology. Current detection strategies, such as Northern Blotting and RT-PCR, require destruction of the cell to extract such information. Researchers at the University of California, Irvine have developed a method to non-destructively assess mRNA levels in a single living cell.

Silent Small Scale Magnetic Resonance Imaging (MRI)

This technology is a novel magnetic resonance imaging (MRI) spatial encoding method to afford a completely silent MRI. In addition, this technology allows miniaturization and is complimentary to both high field and low field designs.

Stroma Biomarkers for Prostate Cancer Diagnosis and Prognosis

Stroma, or connective tissue, consisting namely of fibroblasts and pericytes, are known to interact with nearby tumors and play a major role in cancer progression. Researchers have developed a method of analyzing stroma gene expression in order to more accurately diagnose and assess cancer progression.

Pyrite Shrink-Wrap Laminate As A Hydroxyl Radical Generator

The invention is a diagnostic technology, as well as a research and development tool. It is a simple, easy to operate, and effective platform for the analysis of pharmaceuticals and biological species. Specifically, this platform generates hydroxyl radicals for oxidative footprinting – a technique commonly employed in protein mapping and analysis. The platform itself is inexpenisve to fabricate, scalable, and requires nothing more than an ordinary pipet to use. In addition, it is highly amenable to scale-up, multiplexing, and automation, and so it holds promise as a high-throughput method for mapping protein structure in support of product development, validation, and regulatory approval in the protein-based therapeutics industry.

Patient-Specific Ct Scan-Based Finite Element Modeling (FEM) Of Bone

This invention is a software for calculating the maximum force a bone can support. The offered method provides an accurate assessment of how changes in a bone due to special circumstances, such as osteoporosis or a long duration space flight, might increase patient’s risk of fracture.

A Method For Determining Characteristic Planes And Axes Of Bones And Other Body Parts, And Application To Registration Of Data Sets

The invention is a method for deriving an anatomical coordinate system for a body part (especially bone) to aid in its characterization. The method relies on 3-D digital images of an anatomical object, such as CT- or MR-scans, to objectively, precisely, and reliably identify its geometry in a computationally efficient manner. The invention is a great improvement over the current practice of subjective, user-dependent manual data entry and visualization of bones and organs. The applications for well-defined anatomical coordinate systems include robotic surgeries, models for bone density studies, and construction of statistical anatomical data sets.

Markers to Identify Primary Cells from Tumor Biopsies

Researchers at UC Irvine have developed a novel immunofluorescent imaging strategy to identify cell subsets of interest, in particular cancer stem cells, endothelial progenitor cells, and other primary adherent cells from tumor biopsies.

Microfluidic System for Particle Trapping and Separation

<p>Researchers have developed a novel system and method to rapidly separate particles from liquid. This technology demonstrates lab-on-a-chip potential for particle separation and/or purification. This technology is capable of processing a wide variety of molecules, ranging from cells to smaller biomolecules such as proteins and nucleic acid. Applications of this technology include (but are not limited) use of it for particle separation and quantification for assays, cell preparation, and cell lysing and component separation.</p>

Infant Movement Diagnostics (IMD)

Researchers at UC Irvine have developed a non-invasive wireless method to measure, quantify and analyze infant movement to identify preterm infants at risk for neurological disorders such as cerebral palsy, mental retardation, autism, or intraventricular hemorrhage.

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