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Camellia Sinesis Rapid Growth Platform

Researchers at the University of California Davis have developed a rapid growth platform that aims to decrease crop production time, allow for tunable sensory attributes, and decrease carbon emissions.

Method For Generating Endotoxin-Free Gram-Negative Bacteria

The inventors have discovered that lipid A can be genetically eliminated from Caulobacter crescentus, dependent upon inactivation of the transcriptional regulator Fur and the presence of anionic sphingolipids called ceramide phosphoglycerate. The inventors identified and characterized genes responsible for ceramide phosphoglycerate synthesis. The inventors propose that other Gram-negative bacteria, including E. coli, can be engineered to eliminate lipid A by inactivating their Fur homologs, introducing genes for the synthesis of ceramide phosphoglycerate, or both. Bacteria thus engineered could be used for the endotoxin-free production of small molecule or protein-based pharmaceuticals, therapeutic bacteriophage, RNAs, or endotoxin-free therapeutic bacteria.BACKGROUND The bacterium Escherichia coli is used as a platform for the manufacture of 20-30% of the biopharmaceuticals currently marketed. E. coli, like other Gram-negative bacteria, possesses an outer membrane containing the glycolipid lipopolysaccharide (LPS). The innermost portion of LPS, lipid A, anchors LPS in the outer leaflet of the outer membrane. Lipid A, historically known as endotoxin, is a potent stimulator of the innate immune system in mammals. Even small amounts of endotoxin in the bloodstream can induce an unregulated, systemic inflammatory response known as sepsis. A major hurdle and cost in E. coli-based pharmaceutical production is the removal of endotoxin from each final product. Endotoxin removal strategies are developed on a case-by-case basis to find conditions in which the stable lipid A contaminant can be chemically separated from the desired product while not adversely affecting product recovery or activity. Industrial biotechnology could benefit from additional bacterial production platforms that eliminate the need for extensive processing to remove endotoxins. The challenge is that lipid A is almost always an essential structural component of the OM, meaning that it cannot be eliminated without causing the death of the bacterium. To date, only four species that normally contain lipid A have yielded mutant strains that completely lack lipid A and its biosynthetic precursors. However, these species are not well-developed platforms for industrial biotechnology. An E. coli strain (KPM22) has been developed that survives with only lipid IVA, an intermediate in the lipid A biosynthesis pathway. Lipid IVA contains fewer acyl chains than mature lipid A, causing a ~1000-fold reduction in its endotoxin activity. A modified version of this “endotoxin-free” strain is currently marketed by Lucigen under the trade name ClearColi (https://www.lucigen.com/faq-clearcoli.html).

Slow Ion/Salt-Releasing Biodegradable Hydrogel for Aqueous Applications

This invention is a biodegradable hydrogel mixed with minerals/chemical substances to slowly release ions/salts into the nearby aqueous waterbody through gradual abrasion of surface gel layers performed by underwater current.

(SD2022-180) Method of viral nanoparticle functionalization for therapy and imaging applications

Plant viral nanoparticles (plant VNPs) are promising biogenetic nanosystems for the delivery of therapeutic, immunotherapeutic, and diagnostic agents. The production of plant VNPs is simple and highly scalable through molecular farming in plants. Some of the important advances in VNP nanotechnology include genetic modification, disassembly/reassembly, and bioconjugation. Although effective, these methods often involve complex and time-consuming multi-step protocols.

Biodegradable Potentiometric Sensor to Measure Ion Concentration in Soil

The inventors have developed ion-selective potentiometric sensors for monitoring soil analytes with naturally degradable substrate, conductor, electrode, and encapsulant materials that minimize pollution and ecotoxicity. This novel sensor-creation method uses printing technologies for the measurement of nitrate, ammonium, sodium, calcium, potassium, phosphate, nitrite, and others. Monitoring soil analytes is key to precision agriculture and optimizing the health and growth of plant life. 

Fumigant Detoxification via Reusable Cotton Material

Researchers at the University of California, Davis have developed wearable, highly adsorptive, cotton fabrics that can neutralize fumigants in both open-air and sequestered environments.

Structured "Meat" Processes and Products from Cells Grown in Suspension Culture

Producing meat products using cells grown in culture (instead of via animal husbandry farming) has many benefits and great potential. Current cell-cultured approaches either: (1) use suspension culture to produce homogenous products that don't meet consumer taste expectations for a substitute meat, or (2) organ culture methods to create products that meet consumer taste expectations, but at unacceptably high prices. To address this situation, researchers at UC Berkeley have been developing a process by which cells are grown in free suspension, making possible the economies of scaling that result from using large stirred tanks. After growth, the cells can be assembled into desirable macroscopic structures by controlling the conditions under which the desired multiple cell types and scaffolds are mixed and dewatered. The macroscopic structures include features such as fat marbling and muscle fiber orientation as expected by meat consumers.

Spray Dry Method for Calcium Cross-linked Alginate Encapsulation of Biological and Chemical Moieties via the Use of Chelating Agents

Researchers at the University of California, Davis have developed a one-step spray dry calcium cross-linked alginate encapsulation process where the calcium is released from a chelating agent.

Hydrodealkenylative C(Sp3)–C(Sp2) Bond Scission

UCLA researchers in the Department of Chemistry and Biochemistry have developed a new chemical reaction that combines ozone, an iron salt, and a hydrogen atom donor to enable hydrodealkenylative cleavage of C(sp3)–C(sp2) bonds in a widely applicable manner.

Micro- and Nanocomposite Support Structures for Reverse Osmosis Thin Film Membranes

UCLA researchers in the Department of Civil and Environmental Engineering have invented a novel nanofiltration (NF) and reverse osmosis (RO) composite membrane for water desalination applications.

Devices For Integrated Solar Photodialysis Of Salt Water

Researchers at UCI have developed a compact device for the rapid desalination of water which is driven entirely by renewable solar energy.

A Highly Error-Prone Orthogonal Replication System For Targeted Continuous Evolution In Vivo

Inventors at UC Irvine have engineered an orthogonal DNA replication system capable of rapid, accelerated continuous evolution. This system enables the directed evolution of specific biomolecules towards user-defined functions and is applicable to problems of protein, enzyme, and metabolic pathway engineering.

Compound that Regulates Brassinosteroid Response

Background: Brassinosteroids are essential plant hormones that control growth and development, in addition to playing a critical role in response to stress and infections. Brassinosteroids also induce ethylene synthesis and are therefore related to senescence and ripening. The major overarching issue involves strictly controlling brassinosteroid response in order to promote growth yet limit other negative effects of brassinosteroids.  Brief Description: UCR researchers have identified three compounds that alter brassinosteroid signaling in plants. These chemicals were found to increase the effects of limited brassinosteroids found under normal conditions yet reduce the effects of excess brassinosteroids. This includes promotive effects on plant height, which increase by 100% due to the chemical enhancing the impact of endogenous brassinosteroids. In contrast, the extreme effects seen with addition of high levels of brassinosteroids are substantially reduced upon addition of this chemical, indicating that this chemical may be useful for modulating the effects of brassinosteroids. In conjunction with this, treatment with the chemical resulted in reversal of several ethylene dependent growth phenomena that are also regulated by brassinosteroids. Currently, there is a huge unmet need in the agricultural sector since treatments that modulate brassinosteroid-regulated phenomena do not exist.

Novel Synthesis of 2,5- Dimethylfuran from 5- (Chloromethyl)furfural

Researchers at the University of California, Davis have developed an efficient synthesis of 2,5- dimethylfuran (DMF) from 5- (chloromethyl)furfural (CMF).

Development Of Biodegradable Bait Station For Liquid Ant Bait

Background: Current bait station designs and other pest control tools are not very ideal nor advanced – they leak, become excessively hydrated or dehydrated, and need frequent maintenance. The global pest control services market is expected to grow annually at 5.3% and the industry is always looking for unique ways to conquer them.  Brief Description: UCR Researchers have developed a novel, protected bait station that has controlled liquid bait release. The compact design contains a sugary, insecticide liquid bait that diffuses through an absorbent polymer or gel matrix. Only ants have access to the station and once an ant consumes the bait, the station biodegrades thus eliminating bait station cleanup.

Composition Structure with Tessllated Layers

The technology is a tessellated composite structure that is resistant to tearing and fatigue.It features improved resistance to tearing and fatigue damage and is biased towards compression stress, as opposed to tensile stress.

Method for Efficient Loading of Bioactives into Lipid Membrane Microcapsules

Researchers at the University of California, Davis have developed a method of delivering targeted bioactives that is applicable to the agricultural, food processing, cosmetic, veterinary and medical industries.

Bacterial Biocontrol of Plant Pathogens

Researchers at the University of California, Davis have developed a safe, simple and cost-effective method of preventing fungal wilt - without resorting to chemical or transgenic means./p>

Nitrate-Responsive Synthetic Promoter Produces Nitrate-Regulated Gene Expression in Plants

Inorganic nitrogen is a vital nutrient for plants. Soil nitrate provides as much as 90 percent of the nitrogen taken up by most plants and leads to a dramatic change in gene expression, which is critical to direct the productivity and survival of the plant. Consequently, nitrate is commonly provided by way of fertilizer to improve crop yield. However, many crop plants are inefficient in their ability to utilize the nitrogen. For example, corn and wheat typically only utilize 50 percent of the nitrogen applied to the soil and paddy rice may recoup as little as 30 percent. Nitrogen not used by crops may contribute to severe environmental problems, including pollution of ground water, run-off into nearby bodies of water, and release of greenhouse gases into the atmosphere. Plants take up and assimilate nitrate in response to its availability in the soil and the demands of the plant, but with varying efficiency among species. Understanding and improving the ability of particular plant species to respond to and utilize nitrogen could therefore lead to increased crop productivity and decreased water and air pollution.

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