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Skin Microbiome Treatment For Animals

It is well established that human and animal skin harbours commensal bacteria that generally live on the skin without causing harm. Certain bacteria colonizing healthy skin produce molecules which effectively kill pathogens that cause infections in humans and animals. It was recently reported that patients with diseased skin, such as those with atopy, demonstrate a different array of bacterial species in their commensal skin microbiome compared to patients with healthy skin. Not only is the microbiome of healthy skin qualitatively different to atopic skin in the array of bacterial species present, but functional differences exist between the microbiome of healthy and diseased skin. Bacterial production of antimicrobial molecules is deficient in atopic patients compared to healthy individuals, which may be one reasons why atopic patients are predisposed to S. aureus infections.

Single-Dose, Safe Method to Prevent Stool Eating (Coprophagia) in Dogs

Researchers at the University of California, Davis have developed a means, using an aversion conditioning technique, to deter dogs from eating feces- both their own and that of other animals.

Diagnostic Marker for Chondrodystrophy and Intervertebral Disk Disease Susceptibility in Canines

Researchers at the University of California, Davis, have developed a diagnostic method to identify dogs that are at risk for chondrodystrophy and/or intervertebral disc disease.

A New Pharmaceutical Therapy Target for Depression and Other Central Nervous System Diseases

Researchers at the University of California, Davis have discovered a new signal pathway involved in depression. This could be a potential target of pharmacological treatment of central nervous system disease and specially depression in man and companion animals. The technology could be best practiced with soluble epoxide hydrolase inhibitors, which have high oral bioavailability, good pharmacokinetics, picomolar potency, low toxicity and CNS activity.

Fractal RF Coils for Use in High Field MRI (>3T) Resulting in High Resolution Images

Researchers at the University of California, Irvine have designed a fractal shaped RF coil for magnetic resonance (MR) image acquisition that effectively reduces interference commonly associated with coil loops (such as the birdcage coil) that are in close proximity. Limiting coil interference enables an increase in the flexibility of phased array design and reduces the need for additional system components to cancel out signal noise.

Synthetic Platelets (SynPlats) to Treat Internal & External Bleeding

      Biomaterial nano-particles that mimic the key structural and functional attributes of platelets and have been shown to greatly reduce bleeding time both internally and externally.

Novel Imaging Technique Combines Optical and MR Imaging Systems To Obtain High Resolution Optical Images

Researchers at the University of California, Irvine have developed a novel high resolution imaging technique, referred to as Photo-Magnetic Imaging (PMI), that combines the abilities of optical and magnetic resonance (MR) imaging systems. Images are created with PMI by heating tissue with a light (e.g. laser) and measuring the resulting temperature change with MR Thermometry. This change in temperature can then be related to a tissue’s absorption, scattering, and metabolic properties. PMI addresses the limitations of current optical imaging techniques by providing a repeatable, non-contact, high resolution optical image with increased quantitative accuracy. This technique can be used for a wide-range of applications including but not limited to imaging of small animals for research purposes. This technique may also be used in imaging the tissue and organs of a patient.

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