Position-sensitive radiation detection has been used in semiconductor detector development for decades. Traditional approaches have relied on segmented electrodes to achieve spatial resolution. Conventional semiconductor radiation detectors utilize segmented electrodes where each electrode segment is physically separated and individually read out to determine the position of radiation interactions. Traditional segmented electrode designs have long suffered from highly non-uniform electric fields within the detector volume, particularly at electrode edges and corners. These field concentrations can cause premature breakdown and inconsistent charge collection. This non-uniformity can also lead to position-dependent signal variations, pulse time dispersion, and potential electrical connections between adjacent electrodes from radiation damage. Moreover, common approaches to manufacturing of segmented electrodes requires precise mask alignment and complex fabrication processes, resulting in higher production costs and reduced yields.

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         Recent advancements in nuclear magnetic resonance (NMR) spectroscopy have underscored the need for novel instrumentation, but current commercial instrumentation performs well primarily for pre-existing, mainstream applications. Modalities involving, in particular, integrated electron-nuclear spin control, dynamic nuclear polarization (DNP), and non-traditional NMR pulse sequences would benefit greatly from more flexible and capable hardware and software. Advances in these areas would allow many innovative NMR methodologies to reach the market in the coming years.          To address this opportunity, UC Berkeley researchers have developed a novel high-speed, high-memory NMR spectrometer and hyperpolarizer. The device is compact, rack-mountable and cost-effective compared to existing spectrometers. Furthermore, the spectrometer features robust, high-speed NMR transmit and receive functions, synthesizing and receiving signals at the Larmor frequency and up to 2.7GHz. The spectrometer features on-board, phase-sensitive detection and windowed acquisition that can be carried out over extended periods and across millions of pulses. These and additional features are tailored for integrated electron-nuclear spin control and DNP. The invented spectrometer/hyperpolarizer opens up new avenues for NMR pulse control and DNP, including closed-loop feedback control, electron decoupling, 3D spin tracking, and potential applications in quantum sensing.

Real-time radiation monitoring is critical for public health and emergency response. High-frequency monitoring can generate large amounts of data for dozens of radioactive isotopes though. There is a growing demand for compact radiation detection devices that are also able to quickly and autonomously process these large datasets for anomalies. A UC Santa Cruz researcher has developed machine learning software that synthesizes real-time radiation monitoring data in situ to detect radioactive anomalies.

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Researchers at the University of California, Davis have developed a reconfigurable radiator array that produces a high frequency directed beam via uninterrupted, scalable, electronic beam steering.

Researchers at the University of California, Irvine have developed a novel algorithm that is designed to be integrated with current multi-tone continuous wave (MTCW) lidar technology in order to enhance the capability of lidar to acquire range (distance) of fast-moving targets as well as simultaneous velocimetry measurements. This technology revolutionizes remote sensing by providing high precision, single-shot simultaneous ranging and velocimetry measurements without the need for sweeping.  

Researchers at the University of California, Davis have developed a phased-locked loop coupled array system capable of generating phase shifts in phased array antenna systems - while minimizing signal losses.

Researchers at the University of California, Davis have developed an amplifier technology that boosts power output in order to improve data transmission speeds for high-frequency communications.

An improved method for isothermal nucleic acid detection based on a loop mediated isothermal amplification (LAMP) technique that can be broadly applied for nucleic acid diagnostics.LAMP is an isothermal amplification method that amplifies DNA or RNA. This iteration of LAMP allows for the integration of any short DNA sequence, including tags, restriction enzyme sites, or promoters, into an isothermally amplified amplicon. The technique presented by the inventors allows for the insertion of sequence tags up to 35 nt into the flanking regions of the LAMP amplicon using the forward and backward inner primers (FIP and BIP), and loop primers. The inventors have demonstrated insertion of sequence fragments into the 5’ and middle regions of the FIP and BIP primers, and the 5’ region of the loop primers. In some embodiments, the sequence tag comprises a T7 RNA polymerase promoter, which is then incorporated into the LAMP amplicon (termed RT-LAMP/T7). With the addition of T7 polymerase, the amplicon can be in vitro transcribed, leading to additional amplification of the target molecule into an RNA substrate. This improves the efficiency of the amplification reaction and enables substrate conversion into different nucleic acid types.In other embodiments, the amplified RNA sequence can be detected by CRISPR enzymes, such as RNA-targeting Cas13 systems. 

UCLA researchers in the Department of Electrical Engineering have developed a sub-carrier successive approximation radar (SAR) system with a sufficiently high accuracy to capture three-dimensional images of objects concealed either under the clothing of a person, or within small packages. 

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The technology is a method for multiple users to interact simultaneously with multiple tiled displays.Under this technology, multiple users are allowed to interact with a tiled display with a distributed registration technique.It features easy scalability across different applications, modalities and users and user interactions involve hand gestures or are laser-based.

The technology is a development of a more efficient particle accelerator in terms of energy, cost and space considerations. It is used in particle acceleration applications (cancer treatment, manufacture of components for electronic devices, etc.) The technology is an ultra-compact particle accelerator and particle source. The properties include: Laser Wakefield Accelerator in a solid medium, i.e. crystal in which the Laser Wakefield by charged particle beam bunch. The driver is a high intensity pulsed x-ray. The technology applicable to electron, proton, and ion acceleration and can be used for ultra-compact particle source (neutrons, muons, and neutrinos)

The device is an interactive neuromorphic robot, using to mimic neuro-biological architectures and learning.Properties include:a spiking neural network to control robot behavior, inexpensive parts which are easily available, and two-way learning and behavior shaping.The technology is autonomous, highly mobile, and includes on-board measurement equipment.

Professor Mona Jarrahi in the UCLA Department of Electrical Engineering has developed a technique for operating continuous-wave (CW) terahertz imaging and spectroscopy systems based on photoconductive terahertz sources and/or detectors that uses a low-duty-cycle optical pump, achieving high radiation powers and detection sensitivities without causing thermal breakdown, as well as higher quality image and spectra data.

Researchers at the University of California, Davis have developed a method using standard mobile device sensors assisting with facial authentication to overcome the limitations faced by current methods.

The application of novel manufacturing techniques, chemical modifications and alternative materials produces the next generation of lenses. These lenses are inexpensive, contain improved numerical aperture and can be easily manufactured. Overall, these improvements create new applications for miniaturized optical and optical electronic devices.

Improved reliability of fingerprint authentication is achieved through a unique vascular fingerprint which increases accuracy and verifies liveness.

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The technology is a cost-efficient and highly sensitive micro-mechanical test frames for the characterization of small-scale materials and structures. It is designed for a manufacturing process and self-calibration procedure for the practical use of MEMS resonant sensors as ultra-sensitive load cells. The properties of the technology include:cost-effective fabrication and implementation, load cells with unprecedented combinations of resolution and range, the ability for load cells to be mounted on hybrid micro-mechanical test frames or integrated with on-chip actuators, and the calibration involves no external instrumentation.

Microfluidic devices are poised to revolutionize environmental, chemical, biological, medical and pharmaceutical detectors and diagnostics. The term “microfluidic devices” loosely describes the new generation of instruments that mix, react, count, fractionate, detect, and characterize samples in a micro-electro-mechanical system (MEMS) circuit manufactured through standard semiconductor lithography techniques. Although a wide array of microfluidic technologies are currently available, novel MEMS fluidic systems are needed as scientists continue to work with smaller sample volumes and desire devices with increased sensitivity and effectiveness. Researchers at the University of California, Irvine have developed a unique non-contact system for sorting monodisperse water-in-oil emulsion droplets in a microfluidic device. The technology can be coupled to other on-chip processes to increase device efficiency by sorting out un-reacted droplets.

Researchers at the University of California, Irvine have developed a novel high resolution imaging technique, referred to as Photo-Magnetic Imaging (PMI), that combines the abilities of optical and magnetic resonance (MR) imaging systems. Images are created with PMI by heating tissue with a light (e.g. laser) and measuring the resulting temperature change with MR Thermometry. This change in temperature can then be related to a tissue’s absorption, scattering, and metabolic properties. PMI addresses the limitations of current optical imaging techniques by providing a repeatable, non-contact, high resolution optical image with increased quantitative accuracy. This technique can be used for a wide-range of applications including but not limited to imaging of small animals for research purposes. This technique may also be used in imaging the tissue and organs of a patient.