UCSF researchers have developed an ultrabright and generalizable biosensor that can be used
in live cells to measure the activity of various kinases. The design is modular and extensible:
incorporating kinase-specific docking sites and compatible with different fluorescent proteins
allowing flexibility for multicolor imaging or multiplexed experiments. This research tool appears
to be the first of its kind and has an opportunity to replace current live cell kinase assays, as
current systems require significant modifications to the target kinase.
Protein kinases, kinase reporter, biosensor, bioassay, research tool, live cells, visualizing dynamics, cell signaling, UCSF innovation