Researchers at the University of California, Davis have identified a short peptide which rapidly promotes protein degradation in cancerous enzymes and induces cell differentiation to kill lymphomas.
Researchers at the University of California Davis have discovered a small peptide from viral protein sequence that has been shown to interact with CHD4, a regulating protein that is deregulated in cancerous cells. Specifically, the presence of the discovered peptide causes the CHD4 protein to degrade faster, ultimately killing the cancer cells. The peptide can bind to CHD4 well, facilitate differentiation of cancer cells, slow cancer cell growth, and trigger programmed cell death. Further, using a lymphoma mouse model, the researchers demonstrated inhibition of cancer cell growth without any measurable toxicity. The peptide has potential use for the regulation of the CHD4 protein and oncology treatments.
peptides, cancer cell growth, CHD4, cell differentiation, differentiation therapy, protein regulation, gene expression