Albumin Activation of Human Voltage-Gated Proton Channels: Therapeutic Peptide Modulators
Brief Description
This technology introduces novel peptide modulators of human voltage-gated proton channels (hHv1) that can be exploited for fertility treatments, and inflammatory disease management..
Full Description
Researchers at the University of California, Irvine have discovered the role of albumin in activating human voltage-gated proton channels, influencing sperm capacitation and the innate immune response. This activation mechanism is pivotal in processes such as the capacitation of sperm within the female reproductive tract and the production and release of reactive oxygen species by neutrophils. Exploiting these findings, specific peptides have been developed to modulate hHv1 channels, offering new avenues for therapeutic intervention in fertility and inflammatory diseases.
Suggested uses
Development of novel peptide-based therapeutics for fertility and inflammatory diseases
Advantages
Specific peptide modulators of the hHv1 proton channel offers a novel approach to therapeutics for acute and chronic inflammatory diseases and managing fertility treatments, potentially aiding in both the facilitation and prevention of fertilization
Patent Status
| Country | Type | Number | Dated | Case |
| Patent Cooperation Treaty | Reference for National Filings | WO 2022/251637 | 12/01/2022 | 2020-678 |
Patent Pending
Related Materials
State Of Development
Pre-clinical studies
Contact
- Ronnie Hanecak
- rhanecak@uci.edu
- tel: View Phone Number.
Inventors
- Goldstein, Steven A.N.
- Zhao, Ruiming
