A Sustainable Alternative Route to Produce Methyl Methacrylate

Tech ID: 30303 / UC Case 2015-334-0

Brief Description

A sustainable alternative route to produce Methyl methacrylate (MMA) in an engineered yeast strain.


Methyl methacrylate (MMA) is a critical raw material in the production of acrylic polymers. It is traditionally produced from non-sustainable, hazardous raw materials, such as acetone and hydrogen cyanide using acetone cyanohydrin (ACH). An alternative production route for MMA that is “green” and sustainable would reduce hazardous waste, which has a positive impact on the environment and addresses its traditional production from petroleum.


Researchers at the University of California, Santa Barbara have developed a sustainable alternative route to produce Methyl methacrylate (MMA). By optimizing and engineering yeast strains through metabolic engineering, MAA (methacrylic acid)-CoA is produced directly from glucose at titers approaching 5g/L. This approach allows sustainable raw materials (derived from sugar) to be used as the primary feedstock for MMA production.


  • Increased sustainability
  • Reduced waste
  • Production from glucose at titers approaching 5g/L
  • Vastly improved yields


  • Acrylic polymers
  • Production of MMA

Patent Status

Country Type Number Dated Case
United States Of America Issued Patent 10,676,766 06/09/2020 2015-334


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Other Information


indadvmat, Advanced Materials, Methylacrylyl-CoA (MAA-CoA), Yeast Strain, Acrylic Polymers, Glucose, Sustainable

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