Microbial ecologists are increasingly turning to small, synthesized ecosystems as a reductionist tool to probe the complexity of native microbiomes. Concurrently, synthetic biologists have gone from single-cell gene circuits to controlling whole populations using intercellular signaling.
Researchers from UC San Diego have developed methods, systems, kits, and compositions for culturing bacterial cells, and more particularly for multi-strain ecosystems, including a quorum-regulated multi-lysis system. The system can ensure specific delivery of a therapeutic protein(s) via engineered strains and may also be engineered to output specific profiles of therapeutic proteins to the disease site.
Currently in the working research prototype stage
The invention has a patent pending and is available for licensing and/or sponsored research.
|Patent Cooperation Treaty||Published Application||WO2019237083||12/12/2019||2018-375|
Cell culture, engineered bacteria, lysis, quorum sensing, gene circuit, intercellular signaling