UCLA researchers have developed an algorithm for precisely locating EEG electrodes with respect to the patient’s brain.
Electroencephalography (EEG) measures brain activity by recording electrical activity via electrodes placed on the scalp, and it is used both clinically and in research. EEG measurements made from the scalp originate from sources deep in the brain, but it is difficult to determine the location of these sources with respect to the electrodes placed on the scalp. Currently, the EEG electrodes are precisely placed according to landmark features on the head like the nose or the ear, but the position of brain features with respect to these chronological features can vary considerably between patients. Knowing where electrical activity in the brain originates will help clinical applications (treating epilepsy), as well as research to understand brain behavior more precisely.
UCLA researchers have developed an algorithm and implemented it in computer software to precisely locate EEG electrodes from medical images, specifically MRI images. The image analysis software automatically identifies the electrodes’ shapes and orients them with respect to the MRI brain images for precise localization. The software algorithms can be adapted to use with other imaging tools, such as computed tomography (CT) or camera-based imaging.
The clinical applications include localization of the onset sites of epileptic seizures, along with many additional uses. The research applications include localization of functional systems in the brain that respond to stimuli and that control behavior.This invention has many general applications beyond the focus in EEG. It can be used for identifying the location of objects of approximately-known shape from three-dimensional imagery. Example applications might include identification of underwater objects from ultrasonography and detection of body parts from computer-controlled detectors.
This invention has been fully proven using data collected at UCLA. The algorithms, though not yet optimized, run efficiently in less than one minute. The inventors have plans to further optimize the algorithms and improve robustness. They will also try to integrate the algorithms with available EEG source localization package.
|United States Of America||Published Application||20140341456||11/20/2014||2012-529|