Preliminary Small Molecule-mediated Protein Heterodimerization
Invention Novelty
This technology provides a novel method to effectively modulate protein heterodimerization in a cell by utilizing small molecules.
Technology Description
Researchers at University of California, San Francisco have developed a method of regulated protein heterodimerization that utilizes components from an inducible transcriptional regulatory complex. Heterodimerizer modules can provide a potential way to control engineered cell activity, but there are no FDA approved heterodimerizer drugs yet. The presented technology may address this unmet need; however, this novel invention will still need some scientific and commercial validation with a goal of bringing it to market.
Application
- Potentially control synthetic receptors, signaling molecules, and other molecules in response to the cognate small molecules
- May be used for regulating activity of engineered therapeutic cells
Stage of Development
Proof of concept
Data Availability
Under CDA/NDA
IP STATUS
Pending
Patent Status
| Country | Type | Number | Dated | Case |
| Israel | Issued Patent | 259514 | 05/02/2023 | 2016-046 |
| Hong Kong | Issued Patent | HK40000445 | 03/31/2023 | 2016-046 |
| Mexico | Issued Patent | 399964 | 02/08/2023 | 2016-046 |
| Japan | Issued Patent | 7068169 | 05/06/2022 | 2016-046 |
| United States Of America | Issued Patent | 11,136,562 | 10/05/2021 | 2016-046 |
| Hong Kong | Published Application | 40000578 | 02/14/2020 | 2016-046 |
| India | Published Application | 37/2018 | 09/14/2018 | 2016-046 |
| Eurasian Patent Office | Published Application | 2016-046 | ||
Additional Patents Pending
Other Information
Unpublished at this time
Contact
- Todd M. Pazdera
- todd.pazdera@ucsf.edu
- tel: View Phone Number.
Other Information
Keywords
Small molecule, Protein heterodimerization