Bioreversible Phosphotriester Rnai-Inducing Molecules

Technology Description

RNAi responses have great potential to treat human disease, especially cancer and viral infections.  However, siRNAs are macromolecules with no bioavailability to enter cells and require a delivery agent.  Here we developed RNAi-molecules delivered into cells by the TAT Peptide Transduction Domain (PTD) peptide.  Although we have only performed cell culture experiments, the technology holds promise for eventual development of RNAi therapeutics.

Patent Status