Ptgs2 (Cyclooxygenase-2) Conditional Knockout Mouse

Prostaglandin-endoperoxide synthase 2 (Ptgs2, also known as Cyclooxygenase-2 or Cox-2) is an enzyme involved in the biosynthesis of prostanoids. Aberrant Ptgs2 expression plays major causal and modulatory roles in various cancers, neurodegenerative diseases, and chronic and acute inflammation conditions. Researchers at UCLA have developed a transgenic mouse model that results in conditional deletion of the Ptgs2 gene using Cre/loxP technology. This innovation allows the investigation of Ptgs2 function in specific tissues or at various developmental time points.