Synaptotagmin-4 Knockout Mice

UCLA researchers have developed knockout mice in which the Synaptotagmin 4 (Syt4) gene is deleted. Synaptotagmin 4 is involved in a number of neurobiological events, including vesicle fusion and neurotransmitter release at neuronal synapses. These mice can be used to study many central nervous system (CNS) functions, including memory, learning, fear and anxiety