Mouse Model Deficient for the Proton Sensing Gpcr T-cell Death-associated Gene 8 (tdag)
Tech ID: 20140 / UC Case 2006-624-0
Background
T-cell death-associated gene 8 (TDAG8) functions as a proton sensing GPCR. TDAG8 was originally proposed to bind pro-inflammatory lipids. More recent studies have challenged the identification of lipid agonists for TDAG8 and have suggested that it functions mainly as a proton sensor.
Innovation
Researchers at UCLA have developed a mouse model deficient for TDAG8. It was confirm by using this model that the inactivation of TDAG8 proton sensor abolishes acid-induced production of the secondary messenger cyclic AMP in immune cells.
Related Materials
- Information from Jackson Labs
- Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells. PNAS 2005.
Other Information
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Contact
- UCLA Technology Development Group
- ncd@tdg.ucla.edu
- tel: View Phone Number.
Inventors
- Witte, Owen N.
Other Information
Keywords
research tool
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