A Low Cost and Low Powered Integrated Cell-Sorting Module

Background

Over the past decade, the field of microfluidics has begun to show great promise for research assays and diagnostics as well as for clinical applications. The field has evolved from devices comprised of simple microfluidic channels into complex devices that can mix fluids, pump liquids, perform digital logic, etc. Flow cytometry provides the field with a technology base from which both microfluidic and photonic components can be developed and integrated into a useful device.

Technology Description

UC San Diego researchers have invented a cell-sorting module that can be integrated with a flow-cytometry chip and system architecture for automated, closed-loop, cell detection and sorting. The invention provides a piezoelectrically actuated micro-sorter that operates at low power and low voltage and can deflect and sort single particles and cells at high speed. The micro-sorter can be added to existing microfluidic systems to perform cell sorting. To achieve closed-loop operation—with upstream fluorescence detection and downstream sorting—the invention provides algorithms for real-time signal processing and control. The invention presents, among others, the advantages of on-chip integration, automation with verification, low power operation, simple and low-cost fabrication, and small footprint.

Intellectual Property Info

This invention has a patent pending and is available for sponsored research and/or licensing.

Patent Status