The invention gives a novel microarray to detect proteolytic activity in clinical samples (plasma, etc.) and cleavage of specific protein sequences that are of physiological important for normal cell function.
The approach advances the state-of-the-art, which consists of protease assays based on cleavage of specific short amino-acid sequences designed to detect specific protease activity. The existing protease detection kits are based on 96 well plates with relatively large sample size (0.1 to 0.3 ml) each and they are not designed to detect cleavage of important biological macromolecules.
Proof of concept has been determined.
|United States Of America||Issued Patent||9,733,241||08/15/2017||2007-252|
|United States Of America||Issued Patent||9,222,119||12/29/2015||2007-252|
|United States Of America||Issued Patent||8,940,866||01/27/2015||2007-252|
|United States Of America||Issued Patent||8,507,218||08/13/2013||2007-252|