Murine H60 Gene (plasmid) For Minor Histocompatibility Antigen

Abstract

Minor histocompatibility (H) antigens elicit T cell responses and thereby cause chronic graft rejection and graft-vs.-host disease among MHC identical individuals. Although numerous independent H loci exist in mice of a given MHC haplotype, certain H antigens dominate the immune response and are thus of considerable conceptual and therapeutic importance. The H60 gene was isolated as a cDNA clone from the mouse strain BALB.B. This gene contains an antigenic peptide that elicits a strong cytotoxic T cell response when C57BL/6 mice are immunized with BALB.B spleen cells.

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