Tests for Polycystic Kidney Disease in Domestic Cats

Tech ID: 11315 / UC Case 2004-447-0


DNA Mutation Tests for PKD in domestic cats.

Full Description

DNA mutation tests for polycystic kidney disease in domestic cats have been developed by University of California, Davis researchers. Currently, polycycstic kidney disease affects approximately 40% of the Persian cat population. In addition, this disease has spread to other breeds, and is the most prominent inherited feline disease. Onset of the polycycstic kidney disease is variable and high cost ultrasound techniques are not 100% accurate and require additional visits to veterinarian specialists for diagnosis.

Using direct DNA sequencing, University investigators have identified a causative mutation in the feline PKD1 gene allowing for early detection of this dominant disease.


  • Polycystic kidney disease test in companion animal species (such as domestic cats)
  • Development of better drug and gene therapies for polycystic kidney disease


  • Non-invasive, lower cost DNA methods for diagnosis;
  • Carrier detection at time of birth;
  • Small required amount of DNA for testing; and,
  • More informed breeding decisions.

Related Materials

Patent Status

Country Type Number Dated Case
United States Of America Issued Patent 7,141,376 11/28/2006 2004-447


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  • Erdman, Carolyn A.
  • Grahn, Robert A.
  • Lyons, Leslie A.

Other Information


PKD, polycystic kidney disease, cats, tests

Categorized As