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Pharmacological Tubular Organ Smooth Muscle Relaxation Through Rho-Kinase Inhibition
A revolutionary approach to treating stone disease and improving ureteral distensibility through pharmacological means.
Induced Modification And Degradation Of Intracellular Proteins In Lysosomes: Methylarginine Targeting Chimera (MrTAC)
A revolutionary drug modality for the selective modification and degradation of intracellular proteins in lysosomes.
XNA Aptamer Particle Display Technology
An innovative mid-throughput technique for screening and optimizing threose nucleic acid (TNA) aptamers for protein-binding activity.
Novel molecular target and approach(es) for the bidirectional modulation of T-cell function
Researchers at UC Irvine have identified and tested a molecular target that regulates T cell function during chronic viral infection and cancer. The molecular target is one of the high mobility group proteins (HMGB2). HMGB2 is a DNA binding protein that regulates transcriptional processes, meaning that its modulation will have profound effects on T cell differentiation and ultimate function by altering the expression of many genes.
Small molecule drug leads for p53 mutant cancers
Researchers at UC Irvine have used a computationally powered method to identify small molecule drug leads that exhibited anti-cancer activity in a human-cell-based assay. These small molecules and the approach used to find them will accelerate the research and development of anti-cancer therapeutics.
Pharmacological fortification and/or restoration of protective nerve coverings via a novel therapeutic target
Researchers at UC Irvine have discovered a novel mechanism by which restoration of protective nerve coverings fails in degenerative disease like multiple sclerosis. While therapeutics to slow disease progression exist, there are currently none aimed at preventing or restoring damage to nerve coverings.
Teixobactin O-Acyl Isopeptide Prodrugs
Recently, teixobactin was investigated to treat antibiotic-resistant pathogens, but the drug has yet to reach clinical trial due to its tendency to form gels which prevents accurate dosing. To address this, researchers at the University of California, Irvine have invented a new library of teixobactin related prodrugs which show improved solubility and efficacy versus teixobactin.
Albumin Activation of Human Voltage-Gated Proton Channels: Therapeutic Peptide Modulators
This technology introduces novel peptide modulators of human voltage-gated proton channels (hHv1) that can be exploited for fertility treatments, and inflammatory disease management..
Cyclic Peptide Inhibitors of The SARS-Cov-2 Main Protease
The SARS-CoV-2 virus has rapidly spread across the globe with severe medical, social, and economic costs. The Researchers at the University of California Irvine have designed novel cyclic peptide inhibitors based on a crystal structure of an inactive variant of SARS-CoV, known as Mpro318. Based on a small library of cyclic peptide inhibitors, some candidates showed promising in vitro activity at low micromolar concentrations.
Co-Administration Therapy to Prevent Neurodegeneration and Enhance Neuroprotection
Neurodegenerative diseases are a broad category of illnesses expected to affect 1 in 4 Americans. As they have a variety of underlying mechanisms and pathologies, there are currently no effective methods to prevent or modify disease progression. UCI researchers have developed a potential treatment utilizing a novel combination of two compounds for the abatement of brain inflammation and degeneration.
Novel Prodrug For Anti-Cancer Therapeutic Applications
Inventors at UCI have developed a modified nutrient transporter inhibitor for use as a cancer therapeutic with minimal side effects.
Novel Mixtures For Synergistic Activation Of M-Channels
Epilepsy is a seizure causing neurological disorder that affects over 50 million people, and it is estimated that half are ineffectively treated with current therapeutic options. Researchers at UCI have isolated components of a plant extract used to treat epilepsy in Africa and discovered that, when combined with an existing epilepsy medication, the mixture greatly decreases epileptic episodes and significantly increases survival rates in rodent models of epilepsy.
hHv1 Polypeptide Modulators
A novel class of hHv1 polypeptide modulators designed for selective modulation of hHv1 voltage gated channels, offering new avenues in medical treatment.
Drug Combinations For Treatment Of Tinnitus, Vertigo, and Headache
UC Irvine researchers propose various combinations of medications for treatment of tinnitus and vertigo.
A High Potency CYP3A4 Inhibitor for Pharmacoenhancement of Drugs
CYP3A4 is the most clinically relevant drug metabolizing enzyme in the body, as it is responsible for the oxidation and breakdown of ~60% of current drugs on the market. Researchers at UCI have developed novel CYP3A4 inhibitors, that are highly potent and more specific, exhibit fewer side effects, and are both cheaper, and easier to-synthesize than current commercially available CYP3A4 inhibitors.
Therapy to improve survival in patients with end stage renal disease
Despite many recent improvements in dialysis treatment, End Stage Renal Disease (ESRD) patients on hemodialysis continue to experience an annual mortality rate of approximately 20%, a rate worse than many cancers. Researchers at UCI have identified an association between increased levels of endocannabinoid (EC) in ESRD patients’ serum and decreased risk of death thereby providing a potential therapy to enhance survival times for patients.
A Highly Error-Prone Orthogonal Replication System For Targeted Continuous Evolution In Vivo
Inventors at UC Irvine have engineered an orthogonal DNA replication system capable of rapid, accelerated continuous evolution. This system enables the directed evolution of specific biomolecules towards user-defined functions and is applicable to problems of protein, enzyme, and metabolic pathway engineering.
Controlled 'One-Cell-One-Bead' Encapsulation in Droplets
The invention relates to a technique using a microfluidic device to perform co-encapsulation of samples in droplets and sorting of said droplets. This technique can achieve a one-one-one encapsulation efficiency of about 80% and can significantly improve the droplet sequencing and related applications in single cell genomics and proteomics. .
Small Molecules for Melanoma Treatment
Traditional anti-cancer treatments used for metastatic melanoma (skin cancer) can result in cell toxicity, poor efficacy, and low patient survival. UCI researchers have uncovered a class of potent compounds that inhibit cancer cell growth and induce cancer cell death by targeting RhoJ signaling pathways.
Siderophore-Based Immunization Against Gram-Negative Bacteria
Bacterial pathogens such as E. coli and Salmonella hijack the host’s iron to cause infection. This invention describes an immunization strategy for triggering an immune response against the iron-sequestering agent secreted by the pathogen, thus turning the bacterial virulence mechanism against itself, and thereby resulting in host immunity.
Synthesis of Lipobactins and Teixobactin Analogues – New Antimicrobial Compositions against Gram-Positive Bacteria
With the discovery of penicillin in the 1940’s, many scientists proclaimed the defeat of infectious diseases which had plagued mankind. However, the remarkable healing power of antibiotics unfortunately invited widespread and indiscriminate use of antibiotics. This misuse and overuse of antibiotics has led to the dramatic rise in antibiotic resistant bacterial strains and increased healthcare costs.
Pyrite Shrink-Wrap Laminate As A Hydroxyl Radical Generator
The invention is a diagnostic technology, as well as a research and development tool. It is a simple, easy to operate, and effective platform for the analysis of pharmaceuticals and biological species. Specifically, this platform generates hydroxyl radicals for oxidative footprinting – a technique commonly employed in protein mapping and analysis. The platform itself is inexpenisve to fabricate, scalable, and requires nothing more than an ordinary pipet to use. In addition, it is highly amenable to scale-up, multiplexing, and automation, and so it holds promise as a high-throughput method for mapping protein structure in support of product development, validation, and regulatory approval in the protein-based therapeutics industry.
CYP3A4 Epoxygenase Inhibitors for ER+ Breast Cancer Treatment
Small molecule CYP34A inhibitor oncology therapeutics are being developed in collaboration between scientists at UC Irvine and U of Minnesota. These molecules have been shown effective against ER+ xenograft models of breast cancer. Due to their mechanism of action, these molecules may enhance treatment with tamoxifen and paclitaxel to decrease risk of recurrence.
Imprinted Polymer Nanoparticles
Synthetic polymer nanoparticles (NPs) capable of recognizing specific biomacromolecules and can be used as substitutes for natural antibodies .
Novel Chitosan Derivative as a Systemic Drug Delivery Agent and an Antibiotic Treatment
Researchers at the University of California, Irvine have developed a novel chitosan derivative that may be used simultaneously as a systemic drug delivery agent and a systemic antibiotic treatment.