Browse Category:

Categories

[Search within category]

Dynamic Contrast Optical Coherence Tomography (DyC-OCT): An improved method to quantify blood flow dynamics in deep tissue and microvasculature

Dynamic Contrast Optical Coherence Tomography (DyC-OCT) is a non-invasive technique that obtains high resolution images of blood flow dynamics in deep tissue. It involves real time imaging of the passage of a contrast agent through the vascular and capillary networks. Data analysis can then reveal detailed information on the temporal and spatial dynamics of blood flow.

Tracking Fluorescence Lifetimes in Real-Time

Researchers at the University of California, Davis have developed a novel technique for continuous acquisition, processing, and display of fluorescence lifetimes. This technique allows for rapid and non-invasive real-time tissue diagnosis through a single hand-held or biopsy fiber-optic probe.

Large-Area Photosensor, Large-Area Radiation Detector And Medical Pet Scanner

Available for licensing rights are large-area photosensor panels and large-area radiation detectors, and/or positron emission tomography (PET) scanner that can be formed by assembling the large-area photosensor panels. The sensor panels are made of closely packed “ABALONE” photosensors (described in US patent publication 2013/0112856 A1), and these panels can be easily shipped and assembled into a large, full-body PET scanner. This would be the first ever full-body PET scanner capable of enclosing the entire human body within a seamless gamma-ray sensitive surface, simultaneously, during the examination time. The expected gain in the detection efficiency leads to a proportional reduction in the radioactive dose given to the patient, which in turn opens up the PET diagnostic technique to the general population, through preventive mass screenings of still healthy people for the presence of otherwise hardly detectable malignancies. 

Real-Time Tissue Assessment During Surgical Procedures

When surgically excising a tumor, it is critical to remove some normal tissue surrounding the growth; this ensures that the excised tissue has ‘clean margins’ and that all of the tumor material has been removed.  Currently, to determine if the margins are clean (free of tumor cells) the area may be imaged by X-rays to look for potential tell-tale calcifications and the removed tissue must be prepared and read by a pathologist, which can take up to two days.  Out of all the patients who have had lumpectomies to remove breast cancer, 20-40% of the tissue margins are found to test positive for tumor cells.  These patients required follow up surgeries which increased the risk of further complications and subjected them to additional emotional and financial stress.  However, researchers at the University of California, Davis have developed a novel method and device that allows removed tissue to be examined during the surgery, thereby reducing these additional risks.

Novel Treatments for Neuroimmune-based Psychiatric Disorders

Researchers at the University of California, Davis have identified new targets that will serve as the foundation for developing new treatments along with companion biomarkers, for several neuroimmune-based psychiatric disorders. These targets are the result of unprecedented work employing both mouse and nonhuman primate disease models that has identified a shared set of immune molecules altered in the brains of these two very different species.

Targeting Peptides for Improved Pharmacokinetics and In Vivo Stability

Researchers at the University of California, Davis have developed peptides that target αvβ6 integrin and show promise for imaging and therapeutic applications in a variety of diseases.  These peptides have been designed to optimize pharmacokinetics and target specificity.

Imaging Guided Ablative Laser Surgery

The current method for choosing settings for ablative laser therapy is based on limited information, namely subjective clinician experience and visual assessment of the ablative zone at the treatment site. Researchers at the University of California, Davis have devised an objective real-time method of visualizing the treatment area that will that will allow a laser surgeon to select appropriate ablative laser settings to treat a skin lesions and lesional tissues from other organ systems including, but not limited to: oral mucosa/gingiva, ear/nose and throat, esophagus, gastrointestinal, genitourinary, ophthalmologic and cardiopulmonary.    

Diabodies for Use as Molecular Imaging Agents for Tumors

Radiolabeled anti-αVβ6 diabodies for use as molecular imaging agents for imaging αVβ6-positive tumors with positron emission tomography.

X-Ray Enhanced Polymerization Of Nanostructures And X-Ray Activated Release Of Ions From Nanostructures

A novel drug delivery system that is activated by low dose X-Ray which has further applications in imaging.

MRI Biomarker Of Alzheimer's Disease Degeneration

University of California, Davis researchers have developed a computer algorithm that precisely measures the extent of brain atrophy on structural MRI images over successive time intervals.  The method achieves higher sensitivity and specificity than previous algorithms.  Due to the bias in images and in conventional algorithms, a penalty term reduces the algorithm sensitivity and localization, leading to an under-reporting of real change.  This algorithm restores sensitivity without losing specificity by also incorporating a priori tissue boundary information.

Device and Method for Measuring Beam Quality in CT

Researchers at the University of California, Davis have invented a device and methods for half-value layer (HVL) characterization in computed tomography (CT) to allow a medical physicist to measure the HVL of an X-ray system while the X-ray tube is rotating - that is, during its normal operation without the necessity to make the x-ray tube stationery.

Enhancement Of X-Ray Radiation Using Nanomaterials

New phenomenon of dynamic enhancement of chemical reactions by nanomaterials under hard x-ray radiation.

A Novel Approach to Peptide Labeling for the Imaging of Cancer by PET

New materials and methods that enable the simple inclusion of 18F into cancer-targeting peptides that can be used as radiolabels for PET imaging

Peptide Conjugates for Imaging and Treating Pancreatic Cancer

Radiolabeled PEGylated peptide radiotracer for detection of integrin alpha-v beta-6 in vitro and in vivo

Breast CT Scanner for Early Cancer Detection

Detect breast cancer earlier using an innovative new computed tomography (CT) imaging system.

Method of Preparing Multivalent Single Chain Antibodies (scFv)

Construction of Multivalent Antibody scFv Through Cu(I) Catalyzed 1,3-Dipolar Cycloaddition

Targeted Delivery to the Heart Endothelium

Targeted Delivery of Nanoparticles to the Heart Endothelium with Large Pay-Load Potential, Applicable to Drug/Gene Delivery

Small Molecule Inhibitors of Amyloid-beta Protein Oligomers

Aβ-binding Small Molecules for Alzheimer's Disease Treatment and Imaging

  • Go to Page: