Available Technologies

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This page allows you to search for and view non-confidential descriptions of technologies available for licensing from all ten University of California (UC) campuses.

Tracheostomy Alarm for Accidental Decannulation

This invention describes a reusable alarm for sensing accidental tracheostomy decannulation.

Novel Method Of Imaging Infection Using Radiotracers

UCSF researchers have invented novel radiotracers that allow imaging of both gram-positive and gram-negative bacteria infections using positron emission tomography (PET) to detect spread of infection and to distinguish that from other mimics.

Splice Modulating Oligonucleotides as a Breast Cancer Therapy

UCR researchers have designed novel splice modulating oligonucleotides (SMOs) that decrease expression of the long form of the prolactin receptor, thereby significantly inhibiting the metastatic spread of breast cancer to the lungs and liver. The SMO treatment also increased central death in the primary breast tumor. These SMOs may also target metastases produced by non-prolactin receptor-expressing primary tumors since all cancer stem cells examined so far are positive for the prolactin receptor. The researchers administered SMOs to two highly aggressive metastatic models of breast cancer, BT474 human xenografts, used for testing Herceptin, and a 4T1 syngeneic mouse model, which allows testing with an intact immune system.   Fig. A shows a reduction in the number of metastatic colonies upon treatment with the UCR SMOs.       Fig. B titled "Control" is a stain of the metastatic colonies without SMO treatment. Fig. B titled "PRLR SMO" is a stain of the colonies after 40 days treatment with the UCR SMOs.

Integrated Flexible Filter Photodiode Array For RGB Detection

Inorganic-semiconductor-based photodiodes (PD) have a broadband photoresponse in the visible range.  There are a few approaches to achieve color images with broadband PDs.  The most common one involves the use of a color filter array (CFA) placed over the sensor. Bayer filter, a mosaic of red (R), green (G) and blue (B) filters is the most common color filter array.  In the contrast to inorganic PDs, the main approach to achieve color images with organic photodiodes (OPD) is to narrow the spectral selectivity of the pixels by tuning the absorption spectrum of the photoactive layer.   UC Berkeley researchers have developed an integrated flexible filter photodiode array for RGB detection, using a novel pixel concept and a new filter-substrate-OPD configuration to produce an all-printed full-color OPD imager.  In this approach both sides of flexible substrates are used to combine a broadband OPD and two wide range absorbing filters.  The filter-substrate-OPD configuration utilizes the substrate as a physical separator between the single-photoactive layer OPD array and the filters.   Another feature of current designs of RGB photodiodes is that the filters can be located above the photodiodes, deposited from the same side of the substrate as the photodiode or a completely separate system.  For example, in inorganic photodioes the filters are typically located over the photodiodes.  In organic photodiodes the filters are deposited from the same side of the substrate as the photodiode (e.g., in between the photodiode and the substrate) or a completely separate system.

Engineering Cannabinoid Production In Microbes And Plants

Cannabinoids are bioactive molecules naturally produced by the plant Cannabis sativa as a mixture of 70 different structural analogs. Due to their potent pharmacological properties, there is increasing interest in using cannabinoids to treat diseases (e.g., multiple sclerosis and chronic pain) and alleviate ailments (e.g., vomiting and nausea as well as appetite loss). Pure cannabinoid compounds are needed; however, because of similar molecular compositions of these compounds, purification of such compounds from plants is a difficult undertaking.   Researchers at UC Berkeley and LBL have developed genetically modified host cells that produce cannabinoid compounds or cannabinoid precursors and also methods of synthesizing such compounds or precursors.  The invention achieves high titer bioconversion of simple sugars to known and potentially novel cannabinoids by metabolic engineering of heterologous hosts.

Finite-State Machines For DNA Information Storage

DNA can store petabytes of information per gram and can last intact for tens of thousands of years.  This makes it an appealing prospect for long-term archival storage.  However, DNA synthesis, sequencing, and replication are prone to errors, which limit its potential as a storage medium.  These errors can be controlled by applying the tools of information theory, treating DNA storage as a noisy channel coding problem.  Several coding schemes for DNA storage have been proposed that address the interrelated issues of error avoidance, error correction and redundancy.  There are currently no schemes that address all the above.    Researchers at UC Berkeley have combine some of these ideas, and introduced new ones, using a modular strategy for code design.  With this method, codes can be assembled to meet requirements including error-avoidance, error-correction (resistant to corruption of the information by substitutions, insertions, duplications, or deletions that are introduced during sequencing or replication of the DNA), and demarcation of metadata.  The DNA generated by the codes is free of short local repeats and other (foldback) structure.  The codes generated by this method are flexible in that they arise by systematic combination of state machines, each machine formally representing a particular transformation of the input sequence.  So, for example, one state machine might be used to introduce a "watermark" signal that helps protect against insertion/deletion errors; another state machine could be used to convert the binary sequence into a ternary sequence (or mixed-radix sequence); another state machine would convert the ternary or mixed-radix sequence into a non-repeating DNA sequence; and another state machine to model the errors that are introduced during sequencing. 

Identification Of A Factor That Promotes Human Hematopoietic Stem Cell Self-Renewal

The Mikkola group at UCLA has discovered a novel regulator of hematopoietic stem cell self-renewal. The overexpression of this regulator increases the yield of ex vivo stem cell expansion and could thereby improve the efficiency of stem cell therapies. 

A Mouse Model of Human Papillomavirus (HPV) infection for Drug Discovery

UCSF researchers have generated and validated a K14-HPV16 transgenic mouse model, in which transgene expression produces neoplastic progression that fully resembles the gynecological and other epithelial dysplastic lesions induced by high risk HPVs. This model offers an invaluable tool for studying HPV infection and developing new drugs for HPV treatment.