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Pancreatic Differentiation Process

Diabetes is an autoimmune disease in which the immune system attacks and destroys the insulin-producing beta cells in the pancreas. Islet transplantation is a suitable therapy for diabetes, but the scarceness of islet donors makes this approach practically impossible in a higher scale. Promising alternative cell sources for treating diabetes comes from human embryonic stem cells (hESCs), and numerous groups have generated functional insulin-producing cells in vitro using stepwise differentiation protocols that mimic pancreatic development, including from diabetic patients. However, the limited transcriptomic data on these cells indicate that there remain marked differences between the most mature hESC-derived cells and primary human adult beta cells. Therefore, improvements in methodologies for proper maturation of beta-cells in vitro continues to be an intense area of research.

Defending Side Channel Attack In Addictive Layer Manufacturing Systems

Additive layer manufacturing systems, also known as 3D printers, are a powerful tool for manufacturers in both rapid prototyping stage and full-scale production. Sensitive intellectual property is carried in the electronic information of the design files utilized by 3D printers. However, the physical characteristics of the machine in operation, including power, temperature, sounds, and motion can also reveal sensitive information that could be used to reverse-engineer a product. The inventors at UCI have demonstrated the threat posed by such side-channel attacks, and have developed countermeasures that obscure information which would otherwise be exposed during printer operation.

Antibodies for Pseudomonas (P.) aeruginosa

Researchers at the University of California, Davis have developed recombinant antibodies (VHH or nanobodies) to diagnose and treat Pseudomonas (P.) aeruginosa infection.

Diagnosis and Treatment of Inflammatory Disease by Glycan Profiling of High Density Lipoprotein (HDL)

Researchers at the University of California, Davis have developed a method for diagnosing an individual patient’s risk of inflammatory disease based on glycan profiling of high density lipoprotein (HDL). The resulting profile is then used to recommend a treatment program of dietary, lifestyle, or pharmaceutical interventions (or combination thereof), to improve health and decrease the risk of inflammation-induced disease by modulating the patient’s HDL glycosylation pattern.

Anchor Based Sequence Clustering Algorithm for Efficient & Accurate Motif Discovery

A new strategy for speeding up motif discovery, an anchor based sequence clustering algorithm (ASC) that works significantly faster and with greater accuracy than current motif finding algorithms.

Non-Human Primate Adenovirus Model of Human Respiratory Disease

Researchers at the University of California, Davis have developed a model of human respiratory disease using a titi monkey adenovirus.

FLT3 Mutations Associated with AC220 Drug Resistance in AML Patients

This invention provides methods for identifying acute myeloid leukemia (AML) patients that have an increased likelihood of a relapse following treatment with AC220.

Efficient Induction of Haploid Plants

Researchers at the University of California, Davis have developed an efficient technique for the haploid induction of plants.