Please login to create your UC TechAlerts.
Request a new password for
Required
No technologies match these criteria. Schedule UC TechAlerts to receive an email when technologies are published that match this search. Click on the Save Search link above
Find technologies available for licensing from all ten University of California (UC) campuses.
Zoledronic Acid As a Therapeutic For Dry Age-Related Macular Degeneration and Stargardt Disease
Brief description not available
Targeting Piezo1 To Treat Inherited And Age-Related Macular Degenerations
Functionalized Sila-Adamantane
Humanized Anti-Integrin aVß8 mAb to Inhibit TGFß Activity and Enhance Anti-Tumor Immunity for Immunotherapy
Hollow Core Optical Waveguiding Enabled By Zero-Index Materials
Researchers at UC Irvine have developed a novel optical fiber technology that uses newly developed “zero-refractive index” material as a guiding medium, overcoming the significant limitations of conventional optical fiber where light properties are limited by glass core material. This novel technology will dramatically improve optical communication transmission speed and power by orders of magnitude.
Radioligand/Theranostic to Detect Glucocorticoid Receptor Expression
COMPOSITIONS AND METHODS FOR REDUCING RNA LEVELS
Human diseases that follow a dominant negative inheritance pattern present a great challenge for treatment using gene therapy methods. In such cases, a copy of an allele is inherited from each parent: one is a pathogenic allele causing a disease phenotype (e.g., by exerting a toxic, gain-of-function effect) and the other is a wild-type (non-pathogenic) allele. Allele-specific targeting is especially important when the wild-type allele is crucial to normal function, e.g., the wild-type allele encodes a protein whose function is critical. There is therefore a need for compositions and methods of allele-specific gene editing. UC Berkeley researchers have created methods and systems for reducing the level of an RNA transcript from a target nucleic acid in an allele-specific manner. Such systems and methods can be used to treat a disease that results from or is caused by a toxic gain-of-function protein.
RNA Writing: Programmable Splicing for Transcriptome Engineering
RNA splicing is a fundamental biological process, in which a pre-mRNA transcript is modified by the endogenous spliceosomal complex into a mature mRNA transcript. This standard process involves a single pre-mRNA molecule “in cis.” Whereas methods for editing DNA using editing enzymes have been described and are currently in use for various gene editing applications, there is a need in the art for methods of editing RNA. UC Berkeley researchers have created a hybrid RNA molecule comprising a targeting region and a donor RNA, and compositions comprising the hybrid RNA molecule which is useful in methods of modifying a target RNA by employing a splicing reaction that joins two distinct RNA molecules “in trans.”