Available Technologies

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This page allows you to search for and view non-confidential descriptions of technologies available for licensing from all ten University of California (UC) campuses.

MyShake: Earth Quake Early Warning System Based on Smartphones

Earthquakes are unpredictable disasters. Earthquake early warning (EEW) systems have the potential to mitigate this unpredictability by providing seconds to minutes of warning. This warning could enable people to move to safe zones, and machinery (such as mass transit trains) to be slowed or shutdown. The several EEW systems operating around the world use conventional seismic and geodetic network infrastructure – that only exist in a few nations. However, the proliferation of smartphones – which contain accelerometers that could potentially detect earthquakes – offers an opportunity to create EEW systems without the need to build expensive infrastructure. To take advantage of this smartphone opportunity, researchers at the University of California, Berkeley have developed a technology to allow earthquake alerts to be issued based on detecting earthquakes underway using the sensors in smartphones. Called MyShake, this EEW system has been shown to record magnitude 5 earthquakes at distances of 10 km or less. MyShake incorporates an on-phone detection capability to distinguish earthquakes from every-day shakes. The UC Berkeley technology also collects earthquake data at a central site where a network detection algorithm confirms that an earthquake is underway as well as estimates the location and magnitude in real-time. This information can then be used to issue an alert of forthcoming ground shaking. Additionally, the seismic waveforms recorded by MyShake could be used to deliver rapid microseism maps, study impacts on buildings, and possibly image shallow earth structure and earthquake rupture kinematics.

Compositions and Methods for Treating Estrogen-Receptor Associated Conditions

 Menopausal hormone therapy (MHT) reduces the risk of developing osteoporosis, fractures, obesity and type II diabetes, yet it is only approved for short-term therapy due to the serious risks associated with long-term therapy (e.g., increased risks of breast cancer, stroke, and heart attacks). To target these indications associated with menopause, it will be necessary to develop safer MHT regimens that can be used as continuous therapy. There are two current strategies for developing safer MHT:  First, estrogens have been combined with the selective estrogen receptor modulator, bazedoxifene, which prevents estrogen binding to ERα, thereby blocking the proliferative effects on the uterus. However, this combination is approved only for short-term treatment of hot flashes. Second, ERβ-selective agonists have been developed; unfortunately, ERβ agonists may not be effective for osteoporosis, weight gain or diabetes because ERα is the major active ER in both bone and adipose tissue.   UC Berkeley researchers have discovered a compound that acts as a reprogramming ERα coligand that could improve safety profile of MHT. The compound was found to bind of to a different site on ERα and reprograms the actions of estradiol. This compound represents a new class of drugs that can be combined with existing estrogens to produce safer MHT regimen for long-term treatment to safely prevent chronic diseases associated with menopause. 

Degraded/Distorted Image Restoration

Brief description not available

Methods and Apparatus for EUV Mask Defect Inspection

Since the 1970s, the semiconductor industry has strived to shrink the cost and size of circuit patterns printed onto computer chips in accordance with Moore’s law, doubling the number of transistors on a computer’s central processing unit (CPU) every two years. The introduction of extreme ultraviolet (EUV) lithography, printing chips using 13-nm-wavelength light, opens the way to future generations of smaller, faster, and cheaper semiconductors. There are serious challenges with EUV masks as compared with conventional optical transmissive mask behavior including the multi-layer stack of silicon and molybdenum as a complex reflector of EUV light. Moreover, research into non-optical solutions (e.g. e-beam) is expected to take many years and $100Ms of dollars to reach market maturity. To address these problems, researchers at UC Berkeley and Berkeley Lab worked with the IMPACT+ research team to create a unique optical approach called Optimized Pupil Engineering (OPE) which can detect and characterize mask defects with an 80% enhancement on defect Signal-to-Noise Ratio (SNR) as compared to current systems. This significant improvement reduces false positives and includes pattern and multilayer defects, while it leverages optical-based reticle platforms on the market today. OPE could one day be also used to characterize a variety of semiconductor masks and not limited to EUV lithography.

Stimulus-responsive Polymers

Synthetic polymer constructs are an important tool in modern medical practice, but the lack of control over their activity limits their utility. The ability to combine structural function with localized interaction has proven extremely successful in stents, but polymer technology has not advanced sufficiently to serve a wider range of needs. PLGA polyesters can be degraded by hydrolysis facilitating their widespread use in medicine and biomedical research. Their dependence on slow hydrolysis makes for long degradation times (half-life of one year in vivo) limiting their applicability. While degradation can be sped up by copolymerization with more hydrophilic monomers; degradation is still too slow for triggered release or degradation.

Improved Esophageal Distensibility Testing Using Electrical Impedance

Manometry is a widely-used method of analysis of motor function of the esophagus; it measures contractions in the esophagus. The problem through is that manometry can’t measure luminal distension during bolus transport, which is as important as esophageal contraction for effective passage of bolus along the length of the esophagus. Researchers at the UC San Diego have conducted detailed studies into improving the real-time application and accuracy of manometry methods and technologies.

Pyrite Shrink-Wrap Laminate As A Hydroxyl Radical Generator

The invention is a diagnostic technology, as well as a research and development tool. It is a simple, easy to operate, and effective platform for the analysis of pharmaceuticals and biological species. Specifically, this platform generates hydroxyl radicals for oxidative footprinting – a technique commonly employed in protein mapping and analysis. The platform itself is inexpenisve to fabricate, scalable, and requires nothing more than an ordinary pipet to use. In addition, it is highly amenable to scale-up, multiplexing, and automation, and so it holds promise as a high-throughput method for mapping protein structure in support of product development, validation, and regulatory approval in the protein-based therapeutics industry.

Practical Method For Synthesizing Self-Healing Polymers

The invention is a design and a synthetic method that enables autonomously self-healing polymers. Unlike any previously reported self-healing substances, this material repairs itself into a single-component solid in a truly autonomous manner, without use of heat, light, any other external stimulus, healing agents, plasticizers, or solvent. The disclosed multiphasic material is prepared from inexpensive components in a facile and scalable manner. Furthermore, the mechanical properties of this elastomer can be easily tuned across a broad range (from soft rubber to hard plastic) by changing several parameters during the synthesis.

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