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Substituted quinolone carboxylic acids and potential therapeutic effects in CNS disorders

Substituted quinolone carboxylic acids and their derivatives modulate the effect of γ-aminobutyric acid (GABA). It could be used to ameliorate CNS disorders related to GABA receptors.

Enhancement Of Crispr Genome Editing

96 Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:Calibri; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} When researching genome instability can arise as a result of mistakes occurring during inappropriate hybridization of RNA to its DNA template, UC Berkeley researchers discovered that use of a Rad51 protein could increase the efficiency of Cas9-mediated target DNA modification.  The Rad51p helped to join stretches of nucleic acids together to repair breaks in DNA by enhancing the binding of Cas9 polypeptide and guide RNA complex to the target DNA.

Compositions for Enhancing Beta Cell Maturation, Health, and Function

Beta cell failure is the central cause of type-2 diabetes. Researchers at UCI have developed molecules for treating diabetes that target proteins on the surface of beta cells and induce their clustering. This clustering results in an increase in insulin secretion and content and promotion of beta cell maturation. Furthermore, the clustering effect seen with these compositions may promote both proliferation and the reversal of de-differentiation.

High-Efficiency Broadband Doubler

Researchers at the University of California, Davis have developed a high-efficiency broadband doubler.

Load Modulation For Doherty Power Amplifier

Researchers at the University of California, Davis have derived a novel range of impedances that result in peak efficiency at power back-off operation conditions for the Doherty power amplifier.

Efficient Solar Energy Conversion to Electricity

Researchers at the University of California, Davis have developed a novel design for a solar power converter. The system uses an efficient selective absorber to harvest solar radiation.

A Method for Induction of Corneal Endothelial Cells from Human Pluripotent Stem Cells (PSCs) via Ocular Lineage Specification

One of the most common causes of loss of vision is by corneal endothelial dystrophy (CED). Moreover, Fuchs CED is the leading cause of age-related blindness in individuals over the age of 40 in the United States affecting ~ 4% of the population. The current standard of care is to perform restorative corneal transplantation, but due to a shortage of healthy human donors, this is a challenge confronting the medical community. One solution would be to develop alternative sources of transplantation material. Human corneal endothelial cells (CESs) are not proliferative and do not regenerate in vivo. Therefore, there is a major interest in development of in vitro expandable cell sources for engineering corneal endothelium.