Optical coherence tomography has entered the clinical domain with great fanfare seeing uptake in ophthalmology and cardiology. Both are applications that involve mechanical scanning. Aside from these, it has not deeply penetrated clinical scenarios where scanning is needed in or around the body. What is limiting uptake is scanning, which is both expense and complex. Passively scanned probes exist but they can only sense the speed of probe’s motion but not the direction, limiting OCT’s usefulness for 3D structure. External tracking can be used but it requires cameras, specialized probes, and is subject to resolution limits. Researchers at the University of California, Davis have developed a technology that enables volumetric imaging with passive scanning OCT probes using only data contained in the collected signal, facilitating 3D tissue visualization. This dramatically increases the range of applications for OCT probes and lowers the cost of probes capable of 3D scanning, adding only minimal system complexity and requiring no external tracking hardware. (Reference figures at bottom.)

A minimally invasive method for selectively cooling the brain to prevent injury while avoiding complications of whole-body hypothermia.

Researchers at the University of California, Davis have developed a combinatorial cancer treatment that enhances IL-15 mediated immune activation while inhibiting STAT3 to suppress myeloid-derived immune suppression in bone and soft tissue sarcomas.

Researchers at the University of California, Davis have developed polypeptide compositions of the peripheral nervous system tau isoform ("big tau") that appear to selectively enhance kinesin-3 motor activity and bias intracellular transport toward anterograde direction to treat diseases linked to impaired axonal transport.

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Researchers at the University of California, Davis have developed single-chain insulin (SCI) technology, an insulin-based therapeutic approach that may improve treatment for diabetes and cancer by combining insulin, IGF, and integrin signaling properties.

Researchers at the University of California, Davis have developed a noninvasive optical technology that simultaneously measures fetal oxygen saturation and blood flow during labor through advanced interferometric spectroscopy.

Researchers at the University of California, Davis have developed a fan-pattern paper phantom enabling continuous and reconstruction-agnostic evaluation of PET spatial resolution under clinical and AI-based reconstruction conditions.