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Somatic loss of Mgat1 as a potential risk factor for Multiple Sclerosis (MS)

Researchers at UCI report the incidence of somatic mutation/ loss in a human gene to increase the risk of some types of Multiple Sclerosis (MS).

Hybricdoma Producing Antibodies To Clqrp

Individuals with genetic immunodeficiency, as well as patients with HIV, cancer, and those undergoing chemotherapy or high risk surgery, are at increased risk for infection. C1q, an important component of the immune system, is known to enhance phagocytosis (cell ingestion of harmful bacteria or other materials). Scientists at UCI have developed antibodies to the receptor for C1q, C1qRp, to be used as a target for prophylactic treatments in populations at high risk of infection.

Substituted quinolone carboxylic acids and potential therapeutic effects in CNS disorders

Substituted quinolone carboxylic acids and their derivatives modulate the effect of γ-aminobutyric acid (GABA). It could be used to ameliorate CNS disorders related to GABA receptors.

Enhancement Of Crispr Genome Editing

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Compositions for Enhancing Beta Cell Maturation, Health, and Function

Beta cell failure is the central cause of type-2 diabetes. Researchers at UCI have developed molecules for treating diabetes that target proteins on the surface of beta cells and induce their clustering. This clustering results in an increase in insulin secretion and content and promotion of beta cell maturation. Furthermore, the clustering effect seen with these compositions may promote both proliferation and the reversal of de-differentiation.

High-Efficiency Broadband Doubler

Researchers at the University of California, Davis have developed a high-efficiency broadband doubler.

Load Modulation For Doherty Power Amplifier

Researchers at the University of California, Davis have derived a novel range of impedances that result in peak efficiency at power back-off operation conditions for the Doherty power amplifier.

Efficient Solar Energy Conversion to Electricity

Researchers at the University of California, Davis have developed a novel design for a solar power converter. The system uses an efficient selective absorber to harvest solar radiation.