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Functionalized Sila-Adamantane

Brief description not available

Hollow Core Optical Waveguiding Enabled By Zero-Index Materials

Researchers at UC Irvine have developed a novel optical fiber technology that uses newly developed “zero-refractive index” material as a guiding medium, overcoming the significant limitations of conventional optical fiber where light properties are limited by glass core material. This novel technology will dramatically improve optical communication transmission speed and power by orders of magnitude.

COMPOSITIONS AND METHODS FOR REDUCING RNA LEVELS

Human diseases that follow a dominant negative inheritance pattern present a great challenge for treatment using gene therapy methods. In such cases, a copy of an allele is inherited from each parent: one is a pathogenic allele causing a disease phenotype (e.g., by exerting a toxic, gain-of-function effect) and the other is a wild-type (non-pathogenic) allele. Allele-specific targeting is especially important when the wild-type allele is crucial to normal function, e.g., the wild-type allele encodes a protein whose function is critical. There is therefore a need for compositions and methods of allele-specific gene editing.   UC Berkeley researchers have created methods and systems for reducing the level of an RNA transcript from a target nucleic acid in an allele-specific manner. Such systems and methods can be used to treat a disease that results from or is caused by a toxic gain-of-function protein.   

RNA Writing: Programmable Splicing for Transcriptome Engineering

RNA splicing is a fundamental biological process, in which a pre-mRNA transcript is modified by the endogenous spliceosomal complex into a mature mRNA transcript. This standard process involves a single pre-mRNA molecule “in cis.”  Whereas methods for editing DNA using editing enzymes have been described and are currently in use for various gene editing applications, there is a need in the art for methods of editing RNA.   UC Berkeley researchers have created a hybrid RNA molecule comprising a targeting region and a donor RNA, and compositions comprising the hybrid RNA molecule which is useful in methods of modifying a target RNA by employing a splicing reaction that joins two distinct RNA molecules “in trans.”