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A Method for Making a Human Alzheimer’s Disease Neuronal Model Using Purified ApoE-HDL

Alzheimer's disease (AD) is a common neurodegenerative disease and the most common cause of dementia. Alzheimer’s disease is defined post-mortem by the increased presence of amyloid plaques and neurofibrillary tangles (NFTs) in the brain. Amyloid plaques are extracellular deposits consisting primarily of amyloid-ß (Aß) peptides, and NFTs are intraneuronal aggregations of hyperphosphorylated tau, a microtubule-associated protein involved in microtubule stabilization. The discovery of new drugs for treating Alzheimer’s disease is currently limited by difficulties in obtaining live neurons from patients and the inability to accurately model Alzheimer’s disease. Animal models of Alzheimer’s disease have been developed, however, these animal models do not completely mimic true human disease, and none of these animal models are neuronal models of the disease. There is a need to develop a human neuronal model that more accurately mimics true human Alzheimer’s disease, and then use such a model for Alzheimer’s disease drug discovery and research.

Small RNA Extraction Kit with High Yield

Prof. Wenwan Zhong and her lab at UCR have developed a method to recover small RNAs using TiO2 fibers which results in a 200-fold improvement in yield when compared to commercially available SiO2 columns. Fig. 1 Schematic of the steps involved in recovering small RNAs using TiO2 fibers and a unique protocol to wash and elute the small RNA.   Fig. 2 Extracting miRNA from MDA-MB-231 cells with TiO2 fibers and SiO2 PureLink miRNA isolation columns. Higher recoveries of endogenous hsa-miR-21 were found with TiO2 fibers when compared with PureLink columns.

Selective Doping of Single-Walled Carbon Nanotubes to Form Conducting Composites

A selective method of charge-transfer doping single-walled nanotubes with conjugated polyelectrolytes (CPEs) to form p-type or n-type conductive composites.

A Photo-Activated Transcription System for Controlling Cas9 Utilizing Red/Far Red Light

The type II bacterial clustered, regularly interspaced, short palindromic repeats (CRISPR) and CRISPR-associated protein 9 (Cas9), referred to as CRISPR-Cas9, serves as a breakthrough technology and platform that is used for genome editing and transcriptional modulation. Recent work has shown that this technology has be adapted to examine the temporal regulation of transcriptional repression or activation by Cas9-based systems utilizing either drugs or via optical regulation.  

Functional Manipulation of the Gut Microbiome Using a Personalized Approach

The use of traditional probiotic microorganisms to provide therapeutic function for the gut microbiome has a number of limitations. Probiotic bacteria do not colonize the gut because they can’t compete with the resident flora that have evolved for that environment. Current probiotics are a single strain which when used in multiple hosts have not had great success in broad populations and are therefore unpredictable. To alleviate the above problem, a new approach is necessary to colonize the human gastrointestinal tract with greater reliability and for therapeutic value to the patient. 

Compact Voltage Sensor For Power-Lines

Power-lines for the distribution and transmission of high-voltage electricity are ubiquitous infrastructure of modern societies. Convenient means exists for measuring the currents in these power-lines. However measuring the voltages between conductors of power-lines is difficult and costly because it typically requires large and expensive equipment due to the high voltages (which can be tens or hundreds of thousands of volts). To address that situation, researchers at UC Berkeley have developed a novel, practical and inexpensive way to measure the conduct-to-conductor voltages of power-lines using components in just one conductor of overhead distribution and transmission power-lines. In addition to voltage, this technology can be augmented to measure current, power, and power flow directions. This Berkeley technology can also applied to power-lines in office buildings, factories and power substations.

Ultra-Thin Titanium Thermal Ground Plane for Cooling Microelectronics

Ultra-thin titanium-based thermal ground planes.

NOVEL BRAIN TECHNOLOGY FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS USING ELECTRICAL STIMULATIONS

This invention is a novel technology developed to treat a patient’s neurological and/or psychiatric conditions. It consists of a system of implantable devices and computational algorithms that not only has autonomous control in sensing and stimulation of electrical signals in the patient’s brain, but also enables interactions with the external environment, thereby enhancing training and learning.