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Potent TMEM16A Small Molecule Treatment for Inflammatory and Reactive Airway Diseases, Asthma, Hypertension, Pain and Cancer

A novel class of 2-acylamino-cycloalkylthiophene-3-carboxylic acid arylamides (AACTs) as potent TMEM16A inhibitors

The Use Of Parathyroid Gland Cells And Their Secreted Factors To Promote Islet Beta Cell Engraftments

This invention identifies a novel method to increases survival of transplanted islets in extra-hepatic sites (subcutaneous and intramuscular) through co-transplantation of pancreatic islet beta cells together with parathyroid glands (PTGs). This treatment can successfully be used for patients with type I diabetes.

Novel Compounds that Target Her3

UCSF researchers have developed a new class of small molecule ligands that specifically target HER3, a receptor tyrosine kinase implicated in numerous cancers.

Novel Biomarker Panel for the Early Diagnosis of Lyme Disease

This diagnostic technology uses a panel of 20 biomarkers to diagnose Lyme disease with much higher sensitivity and accuracy than other currently existing methods. Lyme disease can be detected in peripheral blood samples from patients even at early hard-to-diagnose stages. These aspects of the invention make it indispensable for speeding up recovery and prevention of complications associated with this debilitating illness such as carditis, arthritis, neurological illness and even death.

Liquid Biopsy Diagnostic for Precursor Lesions of Pancreatic Cancer

These highly specific biomarkers distinguish potentially malignant mucinous cysts from benign nonmucinous cysts in the pancreas to help diagnose precursor lesions of pancreatic ductal adenocarcinoma. The biomarkers can be detected through enzymatic assays with exceptional accuracy and sensitivity.

Combination Hormone Therapy for Multiple Sclerosis

This invention identifies FDA-approved selective estrogen receptor modulators (SERMs), that when used alone or in combination with estrogen promote remyelination and thus can potentially be used as therapeutics for multiple sclerosis (MS).

Novel Use of Chitinases for Treatment of Lung Inflammatory and Fibrotic Diseases

A novel approach for the treatment of lung inflammatory and fibrotic diseases by increased or repaired chitinase function in lung tissues

Topical Hesperidin for Treatment of Skin Disorders

Orange peel has been used as a traditional Chinese herbal medicine for wide variety of indications. UCSF scientists showed that hesperidin, found in orange peel, improves the permeability barrier function of the skin and have developed novel formulations that include hesperidin or its analogues/metabolites as topical treatment for several types of skin disorders. In comparison to other bioflavonoids, hesperidin was particularly useful for the treatment of aging human and mouse skin, and to reverse the atrophogenic side effects of topical or systemic glucocorticoids.