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Kelch Like Family Member 11 (Klhl11) Autoantibodies As Markers Of Seminoma Associated Paraneoplastic Encephalitis In Men

Researchers at UCSF and Chan Zuckerberg Biohub have discovered a novel biomarker for an autoimmune disease that affects patients with testicular cancer.  The disease, known as “testicular cancer-associated paraneoplastic encephalitis,” can cause severe neurological symptoms.  The symptoms include loss of limb control, eye movement, and in some cases, speech.  The disease begins with testicular cancer, which in some cases causes the immune system to attack the brain.  Affected patients are often misdiagnosed and appropriate treatment is delayed. 

Urine Metabolomics For Identification Of Novel Biomarkers For Transplant Injury

This invention discloses a method for the non-invasive detection of renal allograft injuries–acute rejection, BK virus, and/or chronic allograft nephropathy–via a panel of novel biomarkers. 

Novel small molecule drugs for the treatment of sleep disorders and depression

UCSF scientists have identified novel small molecules which are selective agonists and inverse agonists of the melatonin receptor types MT1 and MT2. The molecules have high in vitro and in vivo potency and potential to be utilized as a novel therapeutic for treating depression, jet lag, and sleep disorders.

Chemical Modulators of Nurr1

Long thought to be undruggable, Nurr1 is a nuclear receptor and transcription factor involved in the development, maintenance, and survival of midbrain dopaminergic neurons, which makes it an attractive target for developing therapeutics for such indications of Parkinson’s disease, multiple sclerosis, and schitzophrenia.

Brain-Specific Kinase Inhibition to Mitigate Systemic Toxicity

The goal of this invention is to overcome the challenges of previous approaches by selectively targeting treatments to the CNS without peripheral toxicity. Kinase inhibition is targeted to the central nervous system (CNS) by combining brain-permeable kinase inhibitors and a brain-impermeable blocking molecule.

Chimeric Kinase Inhibitors with Increased Activity

This invention describes newly generated kinase inhibitors that demonstrate enhanced and attenuated action over their parent kinase inhibitors. These molecules can be used alone but, when combined with novel blocking molecules, the action of these chimeric kinases can be targeted for action in the central nervous system (CNS).

cBCI: Method and System for Diagnosing and Training Cognitive Fitness and Targeted Neural Network Function Underlying Cognitive Fitness in an Integrated Digital Approach

The inventors have created a brain computer interface (BCI) that serves as a diagnostic and training tool of cognitive abilities and neural network function.

Simultaneous Acquisition Of Multiple Epi-Fluorescence Micrographs

UCSF researchers have developed a novel microscope system which allows multiple images of a single sample to be acquired simultaneously.  These images are structured and, when coupled with conventional structured illumination image processing methods, can provide video rate, super-resolution micrographs.