Available Technologies

No technologies match these criteria.
Schedule UC TechAlerts to receive an email when technologies are published that match this search. Click on the Save Search link above

Find technologies available for licensing from UC San Diego.

A Novel CRISPR-based Screen for Personalized Cancer Therapy

Disease phenotypes are often regulated by interwoven genetic networks. For example, tumor genomes exhibit an extensive variety of genetic and epigenetic changes involved in tumor initiation, metastasis and ultimately, resistance to therapy. Combination therapy to target multiple pathways, as opposed to only single ones, can enhance treatment efficacy. Discovering effective combination therapies for human diseases is challenging with existing methods, due to the cost, effort, and labor required to construct and analyze each combination. There is a need for technological advances to accelerate the identification of effective combinatorial therapies. CRISPR has emerged as a new tool to systemically interrogate cancer genomes and set up the potential for personalized medicine. Personalized medicine is based upon the concept that individual differences can be identified and used to the patient’s advantage for therapy.

An Efficient Gene Editing Approach to Create Transgene-free Mutant Plants

Effective isolation of targeted mutations generated by CRISPR/Cas9 requires not only reasonable editing efficiency, but also an easy method to screen for the mutations. Editing events generated by CRISPR/Cas9 are normally identified by restriction enzyme digestion of PCR fragments or by in vitro digestion using purified Cas9 protein. Both methods are time-consuming and laborious. Simplified screening methods are urgently needed.

GPS-Based Miniature Oceanographic Wave Measuring Buoy System

Oceanic monitoring helps coastal communities, economies, and ecosystems thrive. The coastlines and open oceans prove to be very important to maritime countries for recreation, mineral and energy exploitation, shipping, weather forecasting and national security. As solar power, GPS, and telecomm improvements have been made, directional wave buoys have emerged and set the standard in wave monitoring. Non-directional and directional wave measurements are of high interest to users because of the importance of wave monitoring for successful marine operations. Wave data and climatological information derived from the data are also used for a variety of engineering and scientific applications.

Wireless Communication Using Magnetic Waves in the Human Body

Medical devices and wearable consumer products have fundamental anatomically-driven size constraints that necessitate small form factors. Since most patients and consumers desire long battery life, and battery volume is limited by anatomy, one of the only ways to increase lifetime is to reduce the power of the underlying circuits. The power consumption of wireless communication circuits is often large, and while power can be minimized by restricting the communication distance to just a few meters from sensor nodes to a personal base station as part of a body-area network (BAN), it can still dominate the overall energy budget of a wearable device. Current human body communication (HBC) systems communicate using capacitive electrodes that are placed on the body and generate electric fields that then have fringing currents that travel through conductive biological tissues (in one embodiment – galvanic coupling) or fringing fields that interact with the surrounding environment (in another embodiment – capacitive coupling). Both techniques have slightly better path loss than conventional far-field RF techniques, but suffer from electrode impedance variation, environmental variation, or both, making the design of ultra-low power HBC systems difficult. Establishing methods that improve path gain and thus reduced power consumption will aid the functionality of industry devices greatly. 

Targeting 3-Repeat TAU for the Treatment of Neurodegenerative Tauopathy Disorders

Neurodegenerative disorders with Tau accumulation are a common cause of dementia in the aging population. Alzheimer’s Disease (AD), Pick’s Disease (PiD) and Fronto-temporal lobar degeneration (FTLD) are examples of neurodegenerative disorders with Tau accumulation and are also jointly referred as “taupathies”. Tauopathies are a group of neurodegenerative disorders with accumulation of three-repeat (3R) or four-repeat (4R) Tau. While 3R tau is found in Pick's disease and Alzheimer's disease (AD), 4R tau is more abundant in corticobasal degeneration, progressive supranuclear palsy, and AD.

Novel Sensor to Transduce and Digitalize Temperature Utilizing Near-Zero-Power Levels

Temperature sensors are routinely found in devices used to monitor the environment, the human body, industrial equipment, and beyond. In many such applications, the energy available from batteries or the power available from energy harvesters is extremely limited, thus the power consumption of sensing should be minimized in order to maximize operational lifetime.

Injectable Novel Therapeutic for Post-Myocardial Infarction Repair

Cardiovascular disease manifested as a myocardial infarction (MI) usually results in the irreversible death of heart muscle cells. While medical treatments can mitigate some symptoms, they often fail to prevent heart failure after a MI. The current standard of care for MI relies on surgical intervention via a coronary artery bypass. An alternative therapeutic approach has been taken in the last few years with the introduction of biomaterials designed to promote neovascularization after an MI and help prevent negative left ventricle remodeling by increasing infarct wall thickness and decreasing volume, fibrosis, and infarct size. 

Multifunctional Cement Composites With Load-Bearing And Self-Sensing Properties

As improvements in technology allow for construction of bigger, more uniquely designed skyscrapers, bridges, and motorways that can carry greater loads and are seismically sound, current cement composites are being pushed to their performance limits. Now more than ever, assessing damage to cement composite structures is of integral importance. However, traditional methods can be destructive, subjective, and may not detect previously existing damage, which can be invisible to the naked eye or hidden beneath structural surfaces. Addition of conductive additives, such as carbon nanotubes (CNTs) to cementitious composites attributes both load-bearing and damage self-sensing properties to the composites. However, current formulations and methods for producing these multifunctional cement composites require specialized equipment, are labor, time, and capital intensive, and are not scalable.