Available Technologies

No technologies match these criteria.
Schedule UC TechAlerts to receive an email when technologies are published that match this search. Click on the Save Search link above

Find technologies available for licensing from UC Riverside.

Biomarker for Inflammatory Bowel Disease

Prof. Declan McCole and his colleagues at the University of California, Riverside have identified that increased levels of carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) correlate to a loss of function mutation in a protein tyrosine phosphatase non-receptor type 2 (PTPN2) gene. PTPN2 has been identified as an IBD candidate gene that protects the intestinal epithelial barrier.  Dysfunction of the PTPN2 gene, which encodes the T-cell protein tyrosine phosphatase (TCPTP) protein, contributes to alterations in the intestinal microbiome and the onset of chronic intestinal inflammation which is a symptom of IBD. Loss of function of PTPN2 has resulted in IBD-like symptoms in mice and caused the increased abundance of the intestinal pathobiont adherent-invasive Escherichia coli that binds to CEACAM6 and increases a patient’s susceptibility to IBD. Fig. 1 shows control and PTPN2-KD cell lysates with reduced protein expression of TCPTP (PTPN2) in PTPN2-deficient cells that express increased CEACAM6 protein when compared to control cells  

Probiotic for Inflammatory Bowel Disease

Prof. Declan McCole and his colleagues at the University of California, Riverside have identified segmented filamentous bacteria (SFB) as a symbiont that may be used to treat or prevent the relapse of UC.  Adherent invasive Escherichia coli (AIEC) are in higher abundance in IBD patients and significantly alter intestinal barrier function.  This altered intestinal barrier function may be measured by transepithelial electrical resistance (TER).  In cellular assays and tests on murine enteroids derived from the distal colon, the researchers showed that treatment of IBD with SFB reduced mouse AIEC  and protected against intestinal barrier dysfunction.  The TER measurements in SFB treated Caco-2 cells showed little change from TER of the controls.  Fig. 1 shows that Caco-2 cells cultured on transwells and pretreated with viable SFB (vSFB) protected against pathogenic mouse AIEC (mAIEC) and decreased TER which is a measurement of intestinal barrier function. The cells were also cultured with non-pathogenic K-12 E. coli as a control.  Fig. 2 shows Caco-2 bbe cells grown on transwells and pretreated with either viable SFB (vSFB) or heat-killed SFB (hkSFB). Caco-2 bbe cells treated with vSFB resisted adhesion of mAIEC.

New Non-Platinum Fuel Cell Catalyst

The Kisailus research group at the University of California, Riverside, has  developed a novel fuel cell catalyst made of porous carbon nanofibers doped with inexpensive metal or metal oxide nanoparticles that provide active sites for energy conversion and storage. The active or catalytic nanoparticles are embedded and integrated with graphitic nanofibers and are accessible to the surrounding environment due to high porosity. The extensive graphitic networks within these nanofibers also exhibits enhanced conductivity. Cobalt oxide- graphite composite nanofibers showed equivalent catalytic activity to fuel cell platinum catalysts like platinum on carbon (Pt/C). When operated under fuel cell conditions, the nanofiber formulation provides enhanced durability.  Fig. 1 Metal oxide-graphite composite and porous nanofibers with highly controllable diameter, particle size and performance. Fig. 2 Linear sweep voltametry curves shows that the graphitic nanofibers doped with metal ions have higher current densities than commercial platinum on carbon (Pt/C).  

Method for Early Detection of Edema and Intercranial Pressure

Researchers at UCR have developed a process that uses optical coherence tomography (OCT) on specific regions of the cranium to detect the onset of edema before severe damage can be done to the brain.  By scanning various regions of the brain with OCT, the early stages of cerebral edema may be visualized at a far earlier time point than otherwise possible.  The scattering pattern of reflected light changes in a predictable manner when brain water content increases.  This allows for a quick and accurate determination of a patient’s risk for developing dangerous ICP levels, thus eliminating the need for a invasive precautionary craniectomy. Fig. 1: diagram of the OCT apparatus being used to measure edema in a mouse brain Fig. 2: table demonstrating the time between OCT detection of artificially induced edema and onset of increased ICP  

A Transparent, Self-Healing, Highly Stretchable Ionic Conductor

Researchers at the University of California, Riverside have developed a transparent, highly stretchable, self-healing, ionic conductor.  The conductor is comprised of a polar polymer and an ionic salt solution. The material is held together via charge interactions between these two components, which prevents leakage of the ionic solution out of the material. This material can tolerate strains above 5000% and maintains an optical transmittance of 92%. Additionally, the material is spontaneously reversible (goes back to its original shape) for strains under 50%.  When a sample of this material is cut into two pieces and connected together, the sample spontaneously self-healed under ambient conditions within 24 hours.   Fig. 1 Photos of a healed material sample in the non-deformed state and stretched to five times its original length.   Fig. 2 Optical microscope images of a cut material sample after different healing times at room temperature. The damaged sample fully healed after 24 hours. Scale bar is shown at 500 μm.   Fig. 3 Healing efficiency (recovered fracture toughness) at different ambient temperatures

Development Of Pheromone-Assisted Techniques To Improve Efficacy Of Insecticide Baits Targeting Urban Pest And Species

Background: The pest control industry incurs an estimated $1.7B in damages every year. Current pest management techniques result in insecticide runoff and environmental contamination, which calls for improved bait technologies. Since most urban pests of interest use pheromones for organization and coordination of their colonies, many researchers have explored the possibility of using synthetic trail pheromones as an alternative strategy to mitigate this issue.   Brief Description: UCR Researchers have developed insecticidal baits that use highly target-specific control technologies. This novel pheromone-assisted technique (PAT) has little impact on the environment and non-target organisms. By combining the attractant pheromone of ants and existing bait matrices, they increased discovery and consumption of the baits by foraging ants, thus maximizing efficacy of the baits applied. Moreover, they have produced significant results at extremely low concentrations of the pheromone-assisted bait in comparison to the ones that are currently being used.

Efficient Synthesis of Nanoscale Transition Metal Borides

Researchers at UCR have developed a simple and efficient transition metal boride synthesis.  The transition metal borides are synthesized by directly heating metal chloride and elemental boron in the presence of reducing tin (Sn) between temperatures of 700-900 °C for about eight hours. The resulting transition metal boride products are single-phase nanocrystalline materials with an average size of 100 nm. MoB2, MoB, Mo2B4, Mo2B, CoB, FeB, VB2, NbB, NbB2, TaB2 and WB were all synthesized using this new synthetic method.   Fig. 1a shows a sealed quartz tube that was heated to ~800 °C. The pellet at the bottom of the tube contains the desired transition metal boride product. The top of the tube contains crystallized SnCl2. Fig. 1b is an X-ray diffraction (XRD) pattern taken of crystallized SnCl2.         Fig. 2a is a comparison of the XRD patterns of  MoB2 synthesized by the previously known method of solid state metathesis (red) and the new method described herein (blue).  Fig. 2b is a high resolution scanning electron microscope (HRSEM) image of MoB2 synthesized by previously known solid state metathesis (SSM-MoB2) and Fig. 2c shows materials synthesized by the new method. SSM-MoB2 is contaminated by β-MoB and Mo, whereas Sn-MoB2 reaction products are single phase without contamination. HRSEM shows nanospheres and nanorods for SSM-MoB2 and Sn-MoB2, respectively.  

Gold Catalyzed Hydroamination of Alkynes and Allenes

Researchers at the University of California, Riverside have developed a gold complex that functions as the catalyst used in hydroamination of alkynes and allenes. The catalyst has many forms, such as gold nanoparticles/clusters and gold compounds combined with the salts of other metals. Typically, the catalyst has the following structure: L1 – Au+ - L2. L1 and L2 are unique ligands. The catalyst is robust enough to allow hydroamination at a wide range of temperatures (0˚C - 300˚C). Depending on the starting material/catalyst used, 100% hydroamination is achieved in 6 to 24 hours. Fig. 1 One of the catalytic gold complex catalysts used for hydroamination. Note the presence of the ammonia (NH3) as one of the two ligands. Fig. 2 Examples of catalytic amination of various alkynes with ammonia. The last four compounds are dialkynes, which contain multiple carbon-carbon double bonds. Hydroamination of these compounds leads to the formation of heterocyclic rings.