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Find technologies available for licensing from UC Riverside.

Injectable Magnetic Nanocomposite Implants For Tissue Repair

Background: In 2014, the orthopedic soft tissue repair market was $10.3B, and is expected to grow due to an increasing number of soft tissue injuries with very few alternatives to surgery. Current procedures are very invasive, and require drilling holes followed by bone marrow extraction to repair the damaged tissue. Not only is the procedure costly, but the patient is held in recovery for a very long period of time.  Brief Description: UCR researchers have developed 3D magnetic nanocomposite scaffolds that can be injected into the target site for improved tissue regeneration and healing. The material can fill any shape or size of the defective site in just 2 injections. The first injection targets subchondral bone followed by a second injection that promotes cartilage regeneration. This novel invention will allow the patient to save costs incurred on surgical procedures, and regain full functionality under a shorter recovery time.

Fuel Interchangeability Sensor

Background: Energy usage is increasing exponentially, and the energy commission aims to displace up to 2B gallons of petroleum fuels with natural gas by 2030. With greenhouse gas emissions on the rise, there is a great demand for innovative technologies that will help meet fuel specifications and reduce emissions. An important factor for fuel interchangeability is the Wobbe number. Natural gases from fossils to substituted natural gas (SNG) and renewable natural gas (RNG), all have a Wobbe number. Current methods of measuring the Wobbe number is through bulky, complex and expensive analyzers.   Brief Description: UCR researchers have developed a simple, online method for analyzing Wobbe number continuously. They can accurately identify the Wobbe number by measuring thermal conductivity and pressure of the gas with the help of signal interpretation algorithms. This cost-effective technology can be incorporated into vehicle fuel tanks and allow the vehicle to compensate for the varying fuel properties.

Magnetically Tunable Photonic Crystals Based On Anisotropic Nanostructures

Background: Many companies are venturing into new ways to improve paint technology. Current paramagnetic paint can be applied on anything from building interiors to vehicles so that the color can easily change when electric currents are applied. This nanomaterial paint market is projected to grow to $1.4B by 2017 with many notable end users in the display, chemical and automotive industries.  Brief Description: UCR researchers have discovered photonic crystals that can be easily tuned by changing the magnetic field direction without exertion of power. These novel colloidal crystals have magnetic and anisotropic properties that allow them to reach maximum diffraction intensity at certain angles. This could serve as a platform technology since they can take any suitable material that is susceptible to magnetism and optimize its optical components for assembly into photonic structures.

Computationally Efficient Real-Time Positioning/Navigation with Centimeter Accuracy

Background: Global positioning system (GPS) uses space-based satellites while an inertial measurement unit (IMU) use gyroscopes and accelerometers. Aided inertial navigation systems (INS) harness the strengths of both sensors to reliably measure the system position. Although aided INS can provide positioning information, the computational complexity involved in reliably obtaining high-precision has great room for improvement.  Brief Description: UCR researchers have developed a novel multi-epoch carrier phase integer ambiguity resolution approach combining GPS/IMU data that allows them to achieve centimeter-level global positioning accuracy for precise localization. They successfully transformed the original optimization problem into two more easily solved problems allowing computations to be reduced by several orders of magnitude. This optimization will allow for high accuracy solutions, to be achieved more reliably, with computational loads suitable for real-time applications on low power processors, such as the application processors used in mobile devices.

Small RNAs From Fungal Pathogents Act As Effector Molecules To Suppress Host Immunity

Background: Plant-pathogen relationships have been studied meticulously for many years because fungi are notorious for causing detrimental yield losses. Many have taken a biotechnological approach to combatting fungal infections by genetically engineering fungal-resistant genes into plants. The market segment of genomic-enabled products is projected to grow 10% annually and reach $38.6B by 2019.    Brief Description: UCR Researchers have discovered the underlying mechanism of action of Botrytis cinerea, a fungal pathogen that causes grey mold disease in various plants and crops. They’ve identified novel non-protein effectors, small RNAs, that silence specific genes in the host. These fungal sRNAs are transferred into the host cells to suppress its immunity and achieve full infection. With this insight, we can genetically engineer plants to successfully combat harmful pathogenic attacks by inhibiting small RNA effectors.  

Environmentally Friendly Navigation Techniques

Background: Current navigation systems offer “shortest-distance” or “shortest-time” functions to help avoid traffic congestion but neither of them determine the most fuel efficient route. With rising gas prices and vehicle emissions, a more advanced navigation system with additional functions, such as an environmentally-friendly feature, is needed. This accomplishment can make a huge improvement on increasing fuel costs and air pollution. The in-vehicle navigation system is also expected to competitively penetrate the US market in the next couple years with annual sales quadrupling to $13M.  Brief Description: UCR researchers have developed an innovative vehicle navigation system (VNS) that will allow users to choose a route that is the most gas efficient and emanates less emissions. The energy- and emissions-minimization function is incorporated on top of distance- and time-minimizing functions that currently exists in the traditional VNS. This new intelligent transportation system utilizes a state-of-the-art modal emissions model (CMEM) that encompasses real-world vehicle activity patterns, and can calculate the fuel consumption and emission values of each vehicle trajectory.

A Transposon Vector From Aedes Aegypti For Use In Vertebrate And Invertebrate Gene Transfer

Background: Therapeutic delivery of genes is a rapidly evolving technique used to treat or prevent a disease at the root of the problem. Another widely used variation of this technique is to insert a transgene into animals and crops for production of desirable proteins. The global transgenic market is currently $24B with annual growth projections of 10%.  Brief Description: UCR Researchers have identified a novel transposon from Aedes aegypti mosquitoes. This mobile DNA sequence can insert itself into various functional genes to either cause or reverse mutations. They have successfully developed a transposon vector system that can be used in both unicellular & multicellular organisms, which can offer notable insight to enhance current transgenic technologies as well as methods of gene therapy.

MicroRNA Fractionation

Background: The market landscape of the US global market for microRNA research tool, services, diagnostics and drug discovery is estimated to grow 13% annually and reach $1 billion in the next 4 years. The market continues to grow with many pharmaceutical and biotech companies becoming more and more involved in microRNA research to discover specific microRNA biomarkers for diagnostics and therapeutics. Current techniques are unable to identify which microRNA carriers are the most appropriate for disease diagnosis. In this regard, there are relationships between microRNA dysregulation and human disease in approximately 168 diseases, including cancers, heart disease, diabetes, alcoholism, and obesity.  Brief Description: UCR researchers have developed methods for rapid separation of different microRNA carriers in serum, using asymmetrical flow field flow fractionation or specially designed microchips. They have successfully identified microRNAs carriers as sensitive biomarkers, which will aid in the discovery of more effective therapeutic approaches. 

University of California, Riverside
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