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On Demand Thrust Modulation for Solid Rocket Motors
Brief description not available
Parallel Ventilation System for Bus Cabins
Adaptive Cabin Air Quality Control System Using Real-Time Air Quality Map With And Without On-Board Air Quality Sensor (AQS)
Smart Battery Architecture For Sulfur Silicon Full Cells
Novel Mitochondria-Targeting Abasic Site-Reactive Probe (mTAP)
Professor Linlin Zhao and their team from the University of California, Riverside have developed mTAP, a new chemical probe engineered to selectively bind to abasic sites within mitochondrial DNA without affecting nuclear DNA. Unlike non-specific agents, mTAP is equipped with a mitochondria-targeting group, ensuring its precise localization. This invention is advantageous over current technology because its mechanism of action involves forming a stable chemical bond with damaged DNA sites, thereby protecting mtDNA from enzymatic cleavage and maintaining its replication and transcriptional activities. Fig 1: The UCR mitochondria-targeting water-soluble probe mTAP exclusively reacts with mitochondrial abasic sites, and retains mitochondrial DNA levels under genotoxic stress which are responsible for certain mitochondrial diseases.
Preparation Of Stable 1H-1,2,3-Triazol-5-Ylidenes: New Stable Mesoionic Carbenes
In-Vacuum Front-Surface Type Irradiator (FROSTI) For Active Laser Wavefront Control
Core-Shell Wrapped Sulfur Particles For Li-S Cathode Material