Available Technologies

No technologies match these criteria.
Schedule UC TechAlerts to receive an email when technologies are published that match this search. Click on the Save Search link above

Find technologies available for licensing from UC Berkeley.

Atmospheric Moisture Harvester

Energy-efficient production of water from desert air has not been developed. A proof-of-concept device for harvesting water at low relative humidity was reported; however, it used external cooling and was not desert-tested.   UC researchers have developed a devices to produce water from desert air.  The device employs metal-organic frameworks (MOFs).  One such device deployed in a desert in Arizona produced 100 grams of water per kilogram of MOF-801 per day-and-night cycle, using only ambient cooling and natural sunlight as a source of energy. Another device  employs aluminum-based MOF-303, which delivers more than twice the amount of water. The desert experiments uncovered key parameters pertaining to the energy, material, and air requirements for efficient production of water from desert air.

Magnetic Sensor Using Acoustically Driven Ferromagnetic Resonance

Ferromagnetic resonance (FMR) measures magnetic properties of materials by detecting the precessional motion in of the magnetization in a ferromagnetic sample. Different types of FMR include externally-driven FMR and current-driven FMR. FMR can be excited using a variety of techniques, like cavity excitation, stripline excitation, spin transfer torque, and spin orbit torque, among others These applications are typically not compatible with device applications. They require large cavities, high power drive and use large sample volume in order to be effective. However, FMR has some attractive characteristics. These includes the ability to modulate material permeability and electromagnetic absorption as a function of magnetic applied field. UC investigators have developed a surface acoustic wave (SAW) delay line on a piezoelectric lithium niobate substrate. The delay line consists of a pair of interdigitated transducers (IDTs) – one used to generate a SAW, and the other used to detect the SAW once it has travelled across the gap between the two IDTs. A magnetostrictive ferromagnetic material (in our case nickel) is deposited between these two IDTs, and the strain generated by the SAW is transferred into the film. This generates a time-varying internal magnetic field within the magnetostrictive film. The delay line is operated in the GHz range. By appropriately biasing the magnetic film with an external magnetic field, the magnet can be driven into FMR. In this regime, the magnet beings to strongly absorb the travelling SAW. Thus, by measuring the absorption of the SAW (by comparing the input power incident on the generating IDT to the power measured on the detection IDT), it can be determined whether the magnet has entered FMR. This interaction also substantially alters the phase of the travelling wave – and measurements of this phase difference can also be used to detect FMR. This effect can be used as an extremely sensitive magnetic field sensor by biasing the magnetic film so that it is very close to entering FMR and then measuring the absorption or phase of the SAW as a function of applied magnetic field. In this regime, very small changes in the external magnetic field can cause substantial and easily measurable changes in the output power and output phase measured on the detection IDT. By using industry-standard generation and detection techniques and an input power of 20 mW, these devices should be able to measure magnetic fields on the order of ~100 femtoTesla at room temperature, beating comparable state of the art devices by several orders of magnitude when considering relevant SWaP metrics.

Xylosyl-Xylitol Oligomers And Their Microbial And Enzymatic Productions

Lignocellulosic biomass derived from plant cell walls is the most abundant raw material for biofuels and renewable chemicals production.  Hemicellulose comprises about 30% of the total weight of lignocellulosic biomass. In contrast to cellulose, hemicellulose components are readily depolymerized into short oligomers and released into the liquid phase during pretreatment.  It is of great interest to convert the released hemicellulose components into fuels or other value-add chemicals for building an economical biomass conversion process. There are ten times more microorganisms than human cells in a healthy adult.  The symbiosis between the microbiome and human organs is increasingly recognized as a major player in health and well-being.  Xylooligosaccharides and xylitol, both derived from hemicellulose, can benefit gut flora and oral flora, respectively. Xylooligosaccharides (XOS, also called xylodextrins) are naturally occurring oligosaccharides, found in bamboo shoots, fruits, vegetables, milk and honey.  Industrial scale production of XOS can be carried out with much less expensive lignocellulosic materials by hydrothermal treatment or enzymatic hydrolysis.  A broad range of applications of XOS have been demonstrated, including as functional food, prevention and treatment of gastrointestinal infections, animal feed for fish and poultry, agricultural yield enhancer and ripening agent, and as active agents against osteoporosis, pruritus cutaneous, otitis, and skin and hair disorders.  In the current market, the most important applications of XOS correspond to ingredients for functional foods as a prebiotic, or formulated as synbiotics. XOS has been shown to promote beneficial bacteria Bifidobacterium adolescentis growth in vitro and in vivo.  It has been estimated that the prebiotics market will reach $4.8 billion by 2018. Xylitol is another hemicellulose-derived compound beneficial to human health.  For many bacteria and yeasts, the uptake of non-utilizable xylitol interferes with hexose utilization, which helps the human body to rebuild a healthy microbiome.  Xylitol has been used to prevent middle ear infections and tooth decay.  In addition, xylitol possesses 33% fewer calories but similar sweetness compared to sucrose and has been widely used as a substitute sweetener.  While chemical hydrogenation of xylose remains the major industrial method of xylitol production, microbial fermentation has become more popular in the newly built plants due to lower conversion cost. There exists a need for improved methods of producing xylooligosaccharides and related compounds, such as xylooligosaccharides with xylitol components.    UC researchers discovered a new set of fungal metabolic intermediates, named xylosyl-xylitol oligomers and developed the enzymatic and microbial fermentation method to produce such compounds. The detection and purification methods have also been developed.

Body Piercing Hormone Releasing System

Recent literature has shown that long-acting reversible contraceptives such as hormonal implants and intrauterine devices are twenty times more effective in pregnancy prevention than standard methods suchs as oral contraceptive pills. One barrier to use of hormonal implants, such as Nexplanon, is that it requires provider training in placing the implant and a small surgery to remove the device. Many women have piercings for jewelry, quite commonly of the ears and increasingly commonly of the belly button.  UC Berkeley researcher has proposed a  piercing that allows for delivery of contraceptive (or other) hormone treatments. It is a patient-centered method, in that patients can place and remove it as desired.

Small Molecule Assisted Cell Penetrating Cas9 RNP Delivery

Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Clustered regularly interspaced short palindromic repeats (CRISPR) Cas systems provide a means for modifying genomic information and have the potential to revolutionize the treatment of genetic diseases. Although RNA-programmed Cas9 has proven to be a versatile tool for genome engineering in multiple cell types and organisms, it has been challenging to develop the therapeutics because they require the simultaneous in vivo delivery of the Cas9 protein, guide RNA and donor DNA. Compositions that can increase the efficiency of such delivery, particular in eukaryotic cells, are greatly needed.   UC Researchers have discovered that the inclusion of an agent that decreases the acidity of an endosome inside eukaryotic cells, in a genome editing composition, increased the efficiency of genome editing.  The agent was included in a composition having an RNA-guided endonuclease and an RNA-guided endonuclease and was used for gene editing.

Computed Axial Lithography (CAL) For 3D Additive Manufacturing

Additive manufacturing fabrication methods are proliferating rapidly, with photopolymer-based approaches comprising some of the most prominent methods. These stereolithographic techniques provide a useful balance of resolution, build speed, process control, and capital cost (system metrics that typically must be traded off one against another). Resolving the speed limitations, surface roughness (stair-step artifacts), and requirements for support structures would provide the next major steps forward in the progress of these technologies.To address this potential, researchers at UC Berkeley have developed a system and method that accomplishes volumetric fabrication by applying computed tomography techniques in reverse, fabricating structures by exposing a photopolymer resin volume from multiple angles, updating the light field at each angle. The necessary light fields are spatially and/or temporally multiplexed, such that their summed energy dose in a target resin volume crosslinks the resin into a user-defined geometry. These light-fields may be static or dynamic and may be generated by a spatial light modulator that controls either the phase or the amplitude of a light field (or both) to provide the necessary intensity distribution.

Compositions and Methods for Regulating Ovulation

Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} The most widely known method for fertility control is hormonal contraception, which prevent sperm from entering the uterus. However, hormonal contraceptives present several risks associated with venous thrombosis, heart attacks, strokes, increased insulin resistance, gallbladder diseases, and liver tumors as well as a large number of side effects.  There is a need for alternatives to the currently existing contraceptives.      Polycystic ovary syndrome (PCOS) is an endocrine system disorder that affects approximatlely 10% of women of childbearing age. Almost 5 million women suffer from this condition in the United States alone.  While the exact cause of PCOS is unknown, the common symptoms include enlarged ovaries with many small cysts, inability to ovulate (hence infertility), excess hair growth, and obesity. Many women with PCOS overproduce the male sex hormone, androgens, which results in infertility. The current pharmaceutical intervention mainly includes treatment with birth control pills (steroids), however, there is no cure, because the cause of PCOS is still not known.   UC Berkeley researchers have recently discovered a novel membrane progesterone receptor that controls the ovulation. Overexpressing mice produced 3-times more eggs than control mice. The receptor acts as an enzyme that binds progesterone and produces arachidonic acid.  Arachidonic acid is converted into prostaglandins in the ovaries, and PGE2 has been shown before to trigger follicular growth and ovulation. If the enzyme levels increase, more PGE2 will be produced, and more follicles will mature. If the enzyme is suppressed, the whole ovulation process will be shut down. Since PCOS patients have much higher testosterone levels, the novel enzyme function in these patients is suppressed. So, an activator of this enzyme, which competes off testosterone, will be a better treatment or even a cure against PCOS. Compounds that modulate this enzyme’s function will promote and increase ovulation and will ultimately serve as an infertility treatment. 

Blood Exchange Device

Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} The medical costs of managing an aging world poses significant economic and social challenges and will ultimately require a long-term solution. One reason for waning capabilities in people with advancing age is a progressive decline in organ function.  One way to increase healthy longevity would be to rejuvenate the regenerative and repair capacity of aged tissues. Heterochronic parabiosis is an experimental model where the vasculature of two animals of different ages are surgically joined together to create a shared circulatory system and has been used in stem cell and aging research in the last few decades. Heterochronic parabiosis has been shown to rejuvenate the performance of stem cells from old tissues at some expense to the young subject, but whether this occurs as a result of shared circulatory factors or shared organ systems is unclear.   UC Berkeley researchers have discovered, and constructed, a blood exchange system that permits computer controlled isochronic and heterochronic blood exchange transfers for animals. The blood exchange apparatus is an in vivo tool to replace heterochronic parabiosis. Compared to parabiosis, the in vivo animal study apparatus is faster, better controlled and is more flexible in the range of available and potential assays that can be performed.  The Blood exchange system enables less invasive and better-controlled studies with more immediate translation to therapies for humans.