Optimization Of Lead Small Molecule Inhibitors Of Taspase1 For Cancer Therapeutics

Technology Description

Researchers at UCSF have developed potent and selective small molecule inhibitors of Taspase1, a unique protease that plays a critical role in cancer cell proliferation and survival. Taspase1 is overexpressed in various cancers, including glioblastoma and melanoma, and its inhibition has shown promising results in disrupting tumor growth in preclinical models. This innovative therapeutic strategy is currently at the proof-of-concept stage, with compounds demonstrating strong enzyme inhibition and activity in cancer cell lines.

Stage of Development

proof-of-concept

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Patent Status

Patent Pending