GECCO: A Genetic Engineering Method for Introducing Reactive Amino Acids into Proteins
Tech ID: 34431 / UC Case 2019-164-0
Technology Description
Scientists at UCSF have developed a groundbreaking method to enhance protein functionality by selectively introducing highly reactive amino acids, dehydroalanine (Dha) and dehydrobutyrine (Dhb), directly into proteins. This innovative strategy, called Genetically Encoded Chemical Conversion (GECCO), uses proximity-enabled reactivity to convert natural amino acids into reactive residues within living cells, bypassing the need for chemical treatments. GECCO has demonstrated proof-of-concept success in laboratory settings with applications in protein engineering, glycoprotein synthesis, and biochemistry research.
Stage of Development
Proof-of-concept
Related Materials
- Genetically Introducing Biochemically Reactive Amino Acids Dehydroalanine and Dehydrobutyrine in Proteins - 05/15/2020
Patent Status
| Country | Type | Number | Dated | Case |
| European Patent Office | Published Application | 2019-164 | ||
| Patent Cooperation Treaty | Reference for National Filings | WO2020/206341 | 10/08/2020 | 2019-164 |
Additional Patent Pending
Contact
- Catherine Smith
- Catherine.Smith2@ucsf.edu
- tel: View Phone Number.
