Systems And Methods For Performing Peptide Exchange Reactions Using Placeholder Peptides And Catalytic Amounts Of The Molecular Chaperone TAPBPR
Background
In this case, the technology was improved based upon the surprising discovery that the TAPBPR chaperone acts catalytically on MHC-I-placeholder peptide complexes to create peptide receptive MHC-I species.
Technology Description
Technology is identical to that described in 2018-408-0, except that the ratio of TAPBPR to MHC-I-placeholder peptide complex is less than 1:1. As low as a 1:10,000 ratio of TAPBPR to MHC-I placeholder peptide can be used without an effect on the overall reaction time.
Applications
Peptide receptive MHC-I multimer reagents
MHC-I reagents
Identifying antigenic peptides
Identifying and purifying T cell populations
Advantages
Improved cost effectiveness of making MHC Class I reagents because less of the TAPBPR component needs to be made.
Additional patent claims close off potential loophole in coverage
Intellectual Property Information
| Country | Type | Number | Dated | Case |
| United States Of America | Published Application | 20230059548 | 02/23/2023 | 2019-975 |
| European Patent Office | Published Application | EP 4 136 098 | 02/22/2023 | 2020-284 |
| European Patent Office | Published Application | 4085069 | 11/09/2022 | 2019-975 |
| European Patent Office | Published Application | 4085068 | 11/09/2022 | 2020-297 |
| European Patent Office | Published Application | 402841.2 | 07/20/2022 | 2020-251 |
| United States Of America | Published Application | 20210371499 | 12/20/2021 | 2020-284 |
| United States Of America | Published Application | 20210155670 | 05/27/2021 | 2020-251 |
Additional Patents Pending
Related Materials
Contact
- Jeff M. Jackson
- jjackso6@ucsc.edu
- tel: View Phone Number.
Inventors
- Sgourakis, Nikolaos
Other Information
Keywords
MHC-I, Class I MHC, Antigenic Peptide, Peptide Receptive MHC, MHC multimers, MHC tetramers, MHC reagents, Major Histocompatability Complex, Class I, Chaperone, TAPBPR, Catalytic TAPBPR
