Researchers from the University of California, Irvine have developed a new method and device to efficiently mix and analyze liquid samples on CD-based point of care devices.
·Point of care diagnostic device
·Liquid sample analysis: medical and laboratory settings
·Current methods to analyze liquid samples do not recycle samples, while this method mixes the sample to use the full sample volume for analysis.
·Sample mixing improves the detection sensitivity for the device.
·Because the samples are thoroughly mixed, smaller sample volumes are needed for analysis.
Point of care diagnosis is performed by analyzing patient samples bedside using portable devices. While this method of diagnosis minimizes the need for laboratory analysis, it is hindered by device detection limits. Current device methods to mix samples are ineffective.
The researchers at UCI have created a device that recirculates liquid samples, resulting in homogenous mixing, output signal amplification, and lowers sample volume requirements.
A prototype of this device has been developed and used to test the mechanism in proof-of-concept studies.