Agents for Mitochondrial Biogenesis

Tech ID: 32050 / UC Case 2018-315-3

Abstract

Researchers at the University of California, Davis, have developed compounds for the potential prevention and treatment of mitochondrial dysfunction disorders.

Full Description

Many neurological disorders, including some degenerative diseases, result from insufficient mitochondrial function in neural cells. One strategy to prevent or treat these disorders is to increase the mitochondrial biogenesis to compensate for the impaired function. Currently, there are no FDA-approved drug for the prevention or good treatment of many of these neurological diseases. Therefore, there is a need for therapies of increasing mitochondrial mass, number and/or overall neural function.

Researchers at the University of California, Davis, have developed agents for increasing mitochondrial biogenesis in neural cells. The researchers have successfully tested the treatments in vitro in human fibroblast cells and in vivo mouse models of Parkinson’s disease and optic neuropathy to dose-dependently increase mitochondrial proteins. When used in therapeutic combination, the agents produced a potentiated effect.

Applications

  • Potential prevention and treatment of mitochondrial dysfunction disorders that result in neurological diseases

 

Features/Benefits

  • Dose-dependent increase in mitochondrial protein
  • Potentiated combination effect

Patent Status

Country Type Number Dated Case
Patent Cooperation Treaty Reference for National Filings 2019143560A9 07/25/2019 2018-315
 

Patent Pending

Contact

Learn About UC TechAlerts - Save Searches and receive new technology matches

Inventors

  • Cortopassi, Gino A.
  • Yu, Alfred

Other Information

Keywords

Mitochondrial Biogenesis, Neural Cells, Mitochondrial Dysfunction Disorders, Mitochondrial Proteins, Mitochondria

Categorized As

Additional Technologies by these Inventors