This invention describes a method for preparing an implantable device made from biocompatible polymers for sustained delivery of a substance within a body of human or an animal.
The implantable drug delivery device reduces the consumption of drugs.
Such device provides the sustained drug delivery over an extended period of time.
It increases the local drug concentration.
It can be used to deliver a variety of substances.
Implantable drug delivery devices that are surgically implanted in the body of human or veterinary patient are particularly useable for delivering drugs at sustained rates over extended periods of time. It can achieve relatively high local drug concentration without consuming great amount of drug comparing to the systematic administration.
Researchers at UC Irvine developed methods of preparing implantable substance delivery pellets. The implantable may comprise one or more polymers that can be biodegradable or non-biodegradable. The targeted substance(s) need to be delivered are mixed in the polymer. The substances range from nucleic acids, protein, peptides, to chemicals. Diffusion of the substance(s) may be controlled by the initial dug concentration in the polymer/substance mixture. The size and shape of the pellets can be varied depending on the needs. These pellets can be used to deliver agents for therapeutic purposes; they also can be utilized to establish experimental disease animal models as shown by the same researchers in a neovascularization animal model.
|United States Of America||Issued Patent||7,592,016||09/22/2009||1999-285|
|United States Of America||Issued Patent||6,692,759||02/17/2004||1999-285|