Researchers at the University of California, Davis have developed a mechanism to deliver unique complexes of protective antibodies and probiotics to the gut.
Probiotics are important for helping develop a patient’s immune system. Developing a good gut microbiome is especially important for patients susceptible to enteropathogenic infections (infections of the intestines) – including preterm infants and infants in developing regions. Unfortunately, many probiotics administered orally are damaged upon transit through the stomach and, generally, do not colonize for a significant length of time.
Researchers at the University of California, Davis have developed a mechanism that leverages the characteristics of specific probiotic growth on unique carbohydrates to create novel complexes containing antibodies and commensal bacterial strains to improve the human gut microbiome. Antibodies play a key role in overall immune function, and the physical association of an antibody with commensal bacteria protects the bacteria from intestinal digestion during gastrointestinal transit. Moreover, the bacterial-antibody complex also enhances attachment to host cells, damps host immune response and prolongs colonization. As a consequence, these bacterial-antibody complexes could be a therapy for treating inflammatory-based diseases such as Crohn’s disease and other diseases marked by gut dysbiosis.
Microbiome, Inflammation, Commensals, Enteropathogenic Infections, Gut Bacteria