Gut Microbiome Enhancement via Co-delivery of Antibodies and Activated Bacterial Strains

Tech ID: 31971 / UC Case 2020-016-1

Abstract

Researchers at the University of California, Davis have developed a mechanism to deliver unique complexes of protective antibodies and probiotics to the gut.

Full Description

Probiotics are important for helping develop a patient’s immune system. Developing a good gut microbiome is especially important for patients susceptible to enteropathogenic infections (infections of the intestines) – including preterm infants and infants in developing regions. Unfortunately, many probiotics administered orally are damaged upon transit through the stomach and, generally, do not colonize for a significant length of time.

Researchers at the University of California, Davis have developed a mechanism that leverages the characteristics of specific probiotic growth on unique carbohydrates to create novel complexes containing antibodies and commensal bacterial strains to improve the human gut microbiome. Antibodies play a key role in overall immune function, and the physical association of an antibody with commensal bacteria protects the bacteria from intestinal digestion during gastrointestinal transit.  Moreover, the bacterial-antibody complex also enhances attachment to host cells, damps host immune response and prolongs colonization. As a consequence, these bacterial-antibody complexes could be a therapy for treating inflammatory-based diseases such as Crohn’s disease and other diseases marked by gut dysbiosis.

Applications

  • Improvement of the gut microbiome
  • Therapy for inflammatory-based diseases 

Features/Benefits

  •       Leverages known characteristics of  bacterial consumption of complex carbohydrates
  •       Enhances colonization of commensals
  •       Protects gut bacteria from intestinal digestion, enhances its attachment and dampens host immune response

Patent Status

Patent Pending

Contact

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Inventors

  • Dunne-Castagna, Vanessa
  • German, Bruce
  • Mills, David A.

Other Information

Keywords

Microbiome, Inflammation, Commensals, Enteropathogenic Infections, Gut Bacteria

Categorized As