Identification of Novel NLRP3 Inflammasome Inhibitors

Tech ID: 28864 / UC Case 2017-302-0


The NLRP3 inflammasome is a molecular machine that becomes activated during acute and chronic inflammation and leads to production of biologically active IL-1β and IL-18 that initiate inflammatory responses triggered by tissue damage. The NLRP3 inflammasome has also been implicated in many chronic inflammatory and degenerative diseases from gout, osteoarthritis, atherosclerosis to Alzheimer’s disease. Currently, there are no effective ways to inhibit the NLRP3 inflammasome, thus there is a therapeutic need for this class of molecule.

Technology Description

Researchers at UC San Diego have identified a novel kinase whose inhibition prevents NLRP3 inflammasome activation by all its known stimuli, and the researchers have identified its essential catalytic pocket and mechanism of action.


Aberrant NLRP3 activation is the key promoter to many chronic diseases. Specific inhibitors to this new kinase identified should be useful to treat cryopyrin-associated periodic syndromes, gouty arthritis, osteoarthritis, Alzheimer’s disease, type 2 diabetes, atherosclerosis, lupus, macular degeneration and cancer.


NLRP3 inflammasome activation is required for production of IL-1β. Antibodies to IL-1β have been proven useful in a number of inflammatory diseases and can even reduce the likelihood of secondary cardiovascular events for heart attack victims. IL-1β, however, is also important for protection from infection and IL-1β-blocking drugs can increase infection risk. The researcher's approach will avoid such a risk because it only blocks IL-1β production that depends on the NLRP3 inflammasome, which is not involved in the response to microbial or viral infections.

State Of Development

At this point collaboration with a pharma/biotech company to identify small molecule inhibitors of this kinase would be of interest as well as licensing the technology for further development by the pharma/biotech company.

Intellectual Property Info

A provisional patent has been submitted and the technology is available for licensing.

Related Materials

Patent Status

Country Type Number Dated Case
United States Of America Published Application 2019/038845 12/26/2019 2017-302


Learn About UC TechAlerts - Save Searches and receive new technology matches

Other Information


Inflammation, NLRP3 inflammasome, IL-1ß, cryopyrin-associated periodic syndromes, inhibitors, chronic inflammatory disesases

Categorized As