Treatment of Chronic Cutaneous Wounds via Unique Topical Selective Serotonin Reuptake Inhibitors

Tech ID: 27307 / UC Case 2016-658-0


Researchers at the University of California, Davis have developed a unique topical treatment for chronic cutaneous wounds using selective serotonin reuptake inhibitors.

Full Description

Chronic wounds represent a significant source of morbidity in the United States, and evidence suggests that inflammation contributes to wound chronicity. Targeting this inflammation in wound healing will help lead to targeted therapies that can increase patient quality of life and decrease healthcare costs. Effect on quality of life for patients with chronic wounds is equivalent to that of heart or kidney disease. Unfortunately, treatment options for chronic wounds are limited and at least 30% of the ulcers fail to heal within the first 20 weeks with currently available therapies. Furthermore, there is a high association of diabetic foot ulcers with amputation, highlighting the need for more effective therapies.

Researchers at the University of California, Davis have developed a topical preparation of selective serotonin reuptake inhibitors (SSRI) for the treatment of chronic cutaneous wounds. This method of delivery not only avoids unnecessary trauma to the skin but limits systemic effects. These researchers have shown that their unique topical SSRI formulation leads not only to improved skin cell migration over wounds but also decreased inflammation, resulting in better wound healing.


  • Treatment in chronic cutaneous wounds
  • Pressure sores and ulcers


  • Topical application
  • Selective serotonin reuptake inhibitor
  • Anti-inflammatory
  • Improved chronic wound healing

Patent Status

Country Type Number Dated Case
United States Of America Published Application 20190105260 04/11/2019 2016-658


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  • Gorouhi, Farzam
  • Isseroff, R. Rivkah
  • Nguyen, Chuong Minh
  • Tartar, Danielle M.

Other Information


chronic wound, diabetic foot ulcer, diabetic wound, venous ulcer, stasis ulcer, pressure ulcer, pressure sores, selective serotonin reuptake inhibitor, SSRI

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