Mesenchymal Stem Cell Derived Exosomes for Treating Peripheral Artery Disease

Tech ID: 27100 / UC Case 2015-423-0

Abstract

Researchers at the University of California, Davis have developed a method to isolate exosomes from mesenchymal stem cells that contain signaling molecules that induce angiogenesis. The isolated exosomes can be used for treating peripheral arterial disease.

Full Description

Peripheral arterial disease (PAD) is caused by multiple artherosclerotic blockages of peripheral arteries in the lower extremities and results in a lack of proper blood flow to downstream tissues. Currently, medical treatments that focus on using angioplasty and stent placements are not efficient in treating multiple blockages of small vessels. A potential alternative is to use exosomes enriched in angiogenesis factors to induce angiogenesis to restore blood flow to the effective tissues.

Researchers at the University of California, Davis have developed a method to induce mesenchymal stem cells (MSCs) to produce exosomes that contain therapeutic molecules to promote angiogenesis. The highly purified population of cell derived exosomes is prepared by culturing stem cells producing the cell-derived vesicles under conditions of hyposia and low serum conditions. The exosomes are further isolated via tangential flow filtration which results in an increase in exosome capture compared to regular ultra-filtration. This procedure has the benefit of administering the therapeutic properties of MSCs without the concern of direct stem cell injections. The use of MSC exosomes alone to treat PAD patients is seemingly efficacious and safer way to attenuate associated pathology than use of MSCs.

Applications

  • Promoting general angiogenesis in a patient
  • Wound healing in cellular damage related to heart disease
  • Wound repair in cellular damage related to peripheral arterial disease
  • Wound healing in cellular damage related to a stroke

Features/Benefits

  • Increased production of exosomes from Mesenchymal Stem Cells enriched in angiogenic factors
  • No concern of tumor formation since these are not cells, but simply lipid hound vesicles containing signaling proteins and RNA

Related Materials

Patent Status

Patent Pending

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Inventors

  • Anderson, Johnathon D.
  • Nolta, Jan A.

Other Information

Keywords

Angiogenesis, Exosomes, Ischemic tissue-related diseases, Macrovesicles, Tangential flow filtration, Mesenchymal Stem Cells, Peripheral Artery disease

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