Novel Cyanobacteriochromes Responsive to Light in the Far-Red to Near-Infrared Region

Tech ID: 25815 / UC Case 2016-199-0

Abstract

Researchers at the University of California, Davis have identified new cyanobacteriochromes (CBCRs) that detect and fluoresce in the far-red and near-infrared region of the electromagnetic spectrum.

Full Description

Because human and animal tissues are maximally transparent to far-red and near-infrared light, there has been a growing interest in the development of photosensors that use far-red and near-infrared light for visualizing and actuating responses within live cells. Cyanobacteriochromes (CBCRs), photoreceptor proteins found in cyanobacteria, present a possible solution.

Researchers at the University of California, Davis have identified new CBCRs that detect and fluoresce in the far-red and near-infrared region of the electromagnetic spectrum. These CBCRs are therefore promising lead compounds for development of new reagents for near-infrared fluorescence in humans, providing a more sophisticated method than x-ray imaging.

Applications

  • Fluorescent reporters
  • Optical and photoacoustic contrast agents
  • Optical and photoacoustic tomography

Features/Benefits

  • Safer than UV or x-ray irradiation
  • Superior penetration of these wavelengths of light in human tissues
  • Small (<200 amino acids), monomeric, genetically encoded reporters

Patent Status

Country Type Number Dated Case
United States Of America Published Application 20180354998 12/13/2018 2016-199
 

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Inventors

  • Lagarias, J Clark
  • Rockwell, Nathan

Other Information

Keywords

near-infrared proteins, photoswitch, photoreceptor, fluorescence

Categorized As