Tumor initiation and progression into metastasis are accompanied by complex structural changes in the extracellular matrix and cellular architecture that alters the stiffness in the microenvironment of the cell.
The researchers at the University of California, Irvine, created a Mechanical Responsive Cell System (MRCS) having reporter molecules that can measure the changes in the stiffness in the local microenvironment in vivo. The reporter molecules can be genes, proteins, antibodies, biomarkers, therapeutic agents and homing agents, which can monitor and communicate the progression of cancer through signals, images and data back to the user who can then monitor and control the fate of the transplanted cells.
The MRCS can be used to monitor the initiation and progression of the following:
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