Male Mice Lacking Sry on the Y Chromosome with a Function Autosomal Sry Transgene

UCLA researchers have developed mice in which the Sry gene is deleted from the Y chromosome and inserted onto an autosome as a transgene, effectively transferring testis determination from the Y chromosome to an autosome. When male mice carrying the Sry transgene are mated to wild-type females, they produce four "core" genotypes that can be used as a model to investigate relationships between sex chromosome complement (XX or XY) and gonadal type that influences phenotypic characteristics.