New materials and methods that enable the simple inclusion of 18F into cancer-targeting peptides that can be used as radiolabels for PET imaging
Positron emission tomography (PET) is a highly sensitive, noninvasive method for the detection of cancer. Although the technique is generally available in major oncology clinics, its usefulness is nonetheless restricted by limitations in radiolabeling methodology. PET makes predominant use of the positron-emitting fluorine isotope 18F. Currently, the only practical vehicle for clinical application of 18F in PET is 2-18F-2-deoxy-D-glucose (FDG), which is taken up by many types of tumor cells. The exclusive use of FDG however limits the types of cancers which can be imaged by PET. Certain peptides and small proteins are known to be remarkably sensitive and selective cancer targeting agents. However, the labeling of these peptides with 18F is laborious and impractical in a clinical setting. This invention addresses the above obstacle directly by the attachment of a highly selective fluoride ion binding agent to cancer-specific peptides, allowing immediate radiolabeling with 18F. This eliminates the necessity to perform any synthetic chemistry with 18F, resulting in a highly simplified, automatable labeling protocol which has the potential to revolutionize the application of PET to the cancer problem.
The combination of disease-specific imaging with a highly simplified 18F labeling protocol.
|United States Of America||Issued Patent||7,723,322||05/25/2010||2004-498|